Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort

We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varyin...

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Autores: Salinero Fort, Miguel Ángel, San Andrés Rebollo, Francisco Javier, Cárdenas Valladolid, Juan, Méndez Bailón, Manuel, Chico Moraleja, R. M., Carrillo de Santa Pau, Enrique, Jiménez Trujillo, María Isabel, Gómez Campelo, I., De Burgos Lunar, Carmen, Miguel Yanes, José María De, MADIABETES
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/92802
Acceso en línea:https://hdl.handle.net/20.500.14352/92802
Access Level:acceso abierto
Palabra clave:616.1/.9
Medicina interna
3205 Medicina Interna
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spelling Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohortSalinero Fort, Miguel ÁngelSan Andrés Rebollo, Francisco JavierCárdenas Valladolid, JuanMéndez Bailón, ManuelChico Moraleja, R. M.Carrillo de Santa Pau, EnriqueJiménez Trujillo, María IsabelGómez Campelo, I.De Burgos Lunar, CarmenMiguel Yanes, José María DeMADIABETES616.1/.9Medicina interna3205 Medicina InternaWe aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. We evaluated 2980 patients (52.8% women; 67.3 ± 11.2 years) with 24,159 person-years of follow-up. We recorded 114 cases of AMI and 185 cases of stroke/TIA. The factors that were independently associated with first AMI were age (≥ 75 years vs. < 75 years) (p = 0.019), higher HbA1c (> 64 mmol/mol vs. < 53 mmol/mol) (p = 0.003), HDL-cholesterol (0.90-1.81 mmol/L vs. < 0.90 mmol/L) (p = 0.002), and diastolic blood pressure (65-85 mmHg vs. < 65 mmHg) (p < 0.001). The factors that were independently associated with first stroke/TIA were age (≥ 75 years vs. < 60 years) (p < 0.001), atrial fibrillation (first year after the diagnosis vs. more than one year) (p = 0.001), glomerular filtration rate (per each 15 mL/min/1.73 m2 decrease) (p < 0.001), total cholesterol (3.88-6.46 mmol/L vs. < 3.88 mmol/L) (p < 0.001), triglycerides (per each increment of 1.13 mmol/L) (p = 0.031), albuminuria (p < 0.001), neuropathy (p = 0.01), and retinopathy (p = 0.023).Nature ResearchUniversidad Complutense de Madrid20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/92802reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/928022026-06-02T12:44:21Z
dc.title.none.fl_str_mv Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
title Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
spellingShingle Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
Salinero Fort, Miguel Ángel
616.1/.9
Medicina interna
3205 Medicina Interna
title_short Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
title_full Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
title_fullStr Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
title_full_unstemmed Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
title_sort Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
dc.creator.none.fl_str_mv Salinero Fort, Miguel Ángel
San Andrés Rebollo, Francisco Javier
Cárdenas Valladolid, Juan
Méndez Bailón, Manuel
Chico Moraleja, R. M.
Carrillo de Santa Pau, Enrique
Jiménez Trujillo, María Isabel
Gómez Campelo, I.
De Burgos Lunar, Carmen
Miguel Yanes, José María De
MADIABETES
author Salinero Fort, Miguel Ángel
author_facet Salinero Fort, Miguel Ángel
San Andrés Rebollo, Francisco Javier
Cárdenas Valladolid, Juan
Méndez Bailón, Manuel
Chico Moraleja, R. M.
Carrillo de Santa Pau, Enrique
Jiménez Trujillo, María Isabel
Gómez Campelo, I.
De Burgos Lunar, Carmen
Miguel Yanes, José María De
MADIABETES
author_role author
author2 San Andrés Rebollo, Francisco Javier
Cárdenas Valladolid, Juan
Méndez Bailón, Manuel
Chico Moraleja, R. M.
Carrillo de Santa Pau, Enrique
Jiménez Trujillo, María Isabel
Gómez Campelo, I.
De Burgos Lunar, Carmen
Miguel Yanes, José María De
MADIABETES
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.1/.9
Medicina interna
3205 Medicina Interna
topic 616.1/.9
Medicina interna
3205 Medicina Interna
description We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. We evaluated 2980 patients (52.8% women; 67.3 ± 11.2 years) with 24,159 person-years of follow-up. We recorded 114 cases of AMI and 185 cases of stroke/TIA. The factors that were independently associated with first AMI were age (≥ 75 years vs. < 75 years) (p = 0.019), higher HbA1c (> 64 mmol/mol vs. < 53 mmol/mol) (p = 0.003), HDL-cholesterol (0.90-1.81 mmol/L vs. < 0.90 mmol/L) (p = 0.002), and diastolic blood pressure (65-85 mmHg vs. < 65 mmHg) (p < 0.001). The factors that were independently associated with first stroke/TIA were age (≥ 75 years vs. < 60 years) (p < 0.001), atrial fibrillation (first year after the diagnosis vs. more than one year) (p = 0.001), glomerular filtration rate (per each 15 mL/min/1.73 m2 decrease) (p < 0.001), total cholesterol (3.88-6.46 mmol/L vs. < 3.88 mmol/L) (p < 0.001), triglycerides (per each increment of 1.13 mmol/L) (p = 0.031), albuminuria (p < 0.001), neuropathy (p = 0.01), and retinopathy (p = 0.023).
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/92802
url https://hdl.handle.net/20.500.14352/92802
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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