Surgical Outcomes of Laparoscopic Pelvic Lymph Node Debulking during Staging Aortic Lymphadenectomy in Locally Advanced Cervical Cancer

Lymph node metastasis is an important prognostic factor in locally advanced cervical cancer (LACC), which makes correct staging crucial. In contrast to existing studies evaluating pelvic lymphadenectomy after aortic lymphadenectomy, this study focuses on the pelvic node (PLN) debulking technique whi...

ver descrição completa

Detalhes bibliográficos
Autores: Díaz-Feijoo, Berta|||0000-0002-6451-1817, Acosta, Úrsula, Torne, Aureli|||0000-0003-4700-9507, Gil-Ibáñez, Blanca, Hernández Gutierrez, Alicia|||0000-0002-2494-3041, Domingo, Santiago, Bradbury, Melissa|||0000-0003-4974-8899, Gil-Moreno, Antonio|||0000-0003-1106-5590
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:283300
Acesso em linha:https://ddd.uab.cat/record/283300
https://dx.doi.org/urn:doi:10.3390/cancers14081974
Access Level:acceso abierto
Palavra-chave:Aortic lymphadenectomy
Locally advanced cervical cancer
Pelvic lymph node debulking
Surgical staging
id ES_2dd7b4548127300bfa3d4e254c4916f2
oai_identifier_str oai:ddd.uab.cat:283300
network_acronym_str ES
network_name_str España
repository_id_str
spelling Surgical Outcomes of Laparoscopic Pelvic Lymph Node Debulking during Staging Aortic Lymphadenectomy in Locally Advanced Cervical CancerA Multicenter StudyDíaz-Feijoo, Berta|||0000-0002-6451-1817Acosta, ÚrsulaTorne, Aureli|||0000-0003-4700-9507Gil-Ibáñez, BlancaHernández Gutierrez, Alicia|||0000-0002-2494-3041Domingo, SantiagoBradbury, Melissa|||0000-0003-4974-8899Gil-Moreno, Antonio|||0000-0003-1106-5590Aortic lymphadenectomyLocally advanced cervical cancerPelvic lymph node debulkingSurgical stagingLymph node metastasis is an important prognostic factor in locally advanced cervical cancer (LACC), which makes correct staging crucial. In contrast to existing studies evaluating pelvic lymphadenectomy after aortic lymphadenectomy, this study focuses on the pelvic node (PLN) debulking technique which has the dual objective of staging and cytoreduction. This is a multicenter retrospective study of patients with LACC and pelvic nodes on imaging tests. Feasibility, morbidity and delay in the initiation of chemoradiotherapy (CRT) were evaluated for the PLN debulking by comparing it with a control group of aortic lymphadenectomy alone. Excision of the bulky nodes was possible in 99.4% of patients. There were no differences in complications between the groups and a shorter time from diagnosis and from surgery to the start of CRT was observed in the study group. Background: Few studies have evaluated laparoscopic pelvic lymph node (PLN) debulking during staging aortic lymphadenectomy in locally advanced cervical cancer (LACC). It allows us to know the lymph node status and facilitates the action of chemoradiotherapy (CRT) by reducing tumor burden. We evaluated its feasibility and compared the perioperative morbidity and the time to CRT with a control group. Methods: This was a multicenter retrospective study of patients with LACC FIGO stage IIIC1r who were recipients of CRT. We compared two cohorts: group 1, which consisted of 164 patients with surgical staging by laparoscopic aortic lymphadenectomy and PLN debulking, and group 2, which consisted of 111 patients with aortic lymphadenectomy alone. Results: Excision of the bulky nodes was possible in all patients in group 1 except for one. Surgery lasted a median of 82 min longer in group 1 but there was no greater intraoperative bleeding or increased hospital stay. There were no significant differences in intraoperative or postoperative complications between the groups. A significantly shorter time from surgery to the start of RT was observed in group 1. Conclusions: It is feasible to perform laparoscopic PLN debulking in the same procedure as the staging aortic lymphadenectomy in LACC without increasing surgical or postoperative complications and without delaying the start of CRT compared to single aortic lymphadenectomy.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/283300https://dx.doi.org/urn:doi:10.3390/cancers14081974reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2833002026-06-06T12:50:31Z
dc.title.none.fl_str_mv Surgical Outcomes of Laparoscopic Pelvic Lymph Node Debulking during Staging Aortic Lymphadenectomy in Locally Advanced Cervical Cancer
A Multicenter Study
title Surgical Outcomes of Laparoscopic Pelvic Lymph Node Debulking during Staging Aortic Lymphadenectomy in Locally Advanced Cervical Cancer
spellingShingle Surgical Outcomes of Laparoscopic Pelvic Lymph Node Debulking during Staging Aortic Lymphadenectomy in Locally Advanced Cervical Cancer
Díaz-Feijoo, Berta|||0000-0002-6451-1817
Aortic lymphadenectomy
Locally advanced cervical cancer
Pelvic lymph node debulking
Surgical staging
title_short Surgical Outcomes of Laparoscopic Pelvic Lymph Node Debulking during Staging Aortic Lymphadenectomy in Locally Advanced Cervical Cancer
title_full Surgical Outcomes of Laparoscopic Pelvic Lymph Node Debulking during Staging Aortic Lymphadenectomy in Locally Advanced Cervical Cancer
title_fullStr Surgical Outcomes of Laparoscopic Pelvic Lymph Node Debulking during Staging Aortic Lymphadenectomy in Locally Advanced Cervical Cancer
title_full_unstemmed Surgical Outcomes of Laparoscopic Pelvic Lymph Node Debulking during Staging Aortic Lymphadenectomy in Locally Advanced Cervical Cancer
title_sort Surgical Outcomes of Laparoscopic Pelvic Lymph Node Debulking during Staging Aortic Lymphadenectomy in Locally Advanced Cervical Cancer
dc.creator.none.fl_str_mv Díaz-Feijoo, Berta|||0000-0002-6451-1817
Acosta, Úrsula
Torne, Aureli|||0000-0003-4700-9507
Gil-Ibáñez, Blanca
Hernández Gutierrez, Alicia|||0000-0002-2494-3041
Domingo, Santiago
Bradbury, Melissa|||0000-0003-4974-8899
Gil-Moreno, Antonio|||0000-0003-1106-5590
author Díaz-Feijoo, Berta|||0000-0002-6451-1817
author_facet Díaz-Feijoo, Berta|||0000-0002-6451-1817
Acosta, Úrsula
Torne, Aureli|||0000-0003-4700-9507
Gil-Ibáñez, Blanca
Hernández Gutierrez, Alicia|||0000-0002-2494-3041
Domingo, Santiago
Bradbury, Melissa|||0000-0003-4974-8899
Gil-Moreno, Antonio|||0000-0003-1106-5590
author_role author
author2 Acosta, Úrsula
Torne, Aureli|||0000-0003-4700-9507
Gil-Ibáñez, Blanca
Hernández Gutierrez, Alicia|||0000-0002-2494-3041
Domingo, Santiago
Bradbury, Melissa|||0000-0003-4974-8899
Gil-Moreno, Antonio|||0000-0003-1106-5590
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Aortic lymphadenectomy
Locally advanced cervical cancer
Pelvic lymph node debulking
Surgical staging
topic Aortic lymphadenectomy
Locally advanced cervical cancer
Pelvic lymph node debulking
Surgical staging
description Lymph node metastasis is an important prognostic factor in locally advanced cervical cancer (LACC), which makes correct staging crucial. In contrast to existing studies evaluating pelvic lymphadenectomy after aortic lymphadenectomy, this study focuses on the pelvic node (PLN) debulking technique which has the dual objective of staging and cytoreduction. This is a multicenter retrospective study of patients with LACC and pelvic nodes on imaging tests. Feasibility, morbidity and delay in the initiation of chemoradiotherapy (CRT) were evaluated for the PLN debulking by comparing it with a control group of aortic lymphadenectomy alone. Excision of the bulky nodes was possible in 99.4% of patients. There were no differences in complications between the groups and a shorter time from diagnosis and from surgery to the start of CRT was observed in the study group. Background: Few studies have evaluated laparoscopic pelvic lymph node (PLN) debulking during staging aortic lymphadenectomy in locally advanced cervical cancer (LACC). It allows us to know the lymph node status and facilitates the action of chemoradiotherapy (CRT) by reducing tumor burden. We evaluated its feasibility and compared the perioperative morbidity and the time to CRT with a control group. Methods: This was a multicenter retrospective study of patients with LACC FIGO stage IIIC1r who were recipients of CRT. We compared two cohorts: group 1, which consisted of 164 patients with surgical staging by laparoscopic aortic lymphadenectomy and PLN debulking, and group 2, which consisted of 111 patients with aortic lymphadenectomy alone. Results: Excision of the bulky nodes was possible in all patients in group 1 except for one. Surgery lasted a median of 82 min longer in group 1 but there was no greater intraoperative bleeding or increased hospital stay. There were no significant differences in intraoperative or postoperative complications between the groups. A significantly shorter time from surgery to the start of RT was observed in group 1. Conclusions: It is feasible to perform laparoscopic PLN debulking in the same procedure as the staging aortic lymphadenectomy in LACC without increasing surgical or postoperative complications and without delaying the start of CRT compared to single aortic lymphadenectomy.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/283300
https://dx.doi.org/urn:doi:10.3390/cancers14081974
url https://ddd.uab.cat/record/283300
https://dx.doi.org/urn:doi:10.3390/cancers14081974
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405357885882368
score 15,300719

Registos relacionados