Prenatal exposure to perfluoroalkyl substances and child health
Perfluoroalkyl substances (PFAS), such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), are synthetic chemicals commonly used in industrial and commercial products including consumer care products, fire-fighting foams, ski wax, and oil- and water-repellents for leather, pape...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/585944 |
| Acceso en línea: | http://hdl.handle.net/10803/585944 |
| Access Level: | acceso abierto |
| Palabra clave: | prenatal exposure perfluoroalkyl substances child health birth cohort study Spain exposició prenatal compostos perfluorats salut infantil cohort de naixement Espanya 614 |
| Sumario: | Perfluoroalkyl substances (PFAS), such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), are synthetic chemicals commonly used in industrial and commercial products including consumer care products, fire-fighting foams, ski wax, and oil- and water-repellents for leather, paper, and textiles. Prenatal PFAS exposure may modulate fetal growth, fat accumulation, metabolic function, and immune response yet evidence coming from birth cohort studies is limited. In this thesis we first evaluated the transfer of PFAS from mother to fetus and the determinants of maternal PFAS exposure during pregnancy. This led us to the main objective of this thesis, to evaluate the association between prenatal exposure to PFAS and child health outcomes, specifically: fetal growth and preterm birth, obesity and cardiometabolic risk, and immune and respiratory health in early and mid-childhood. Data from the “Infancia y Medioambiente” (INMA) population-based Spanish birth cohort was used. The results from the present thesis indicate that PFOA can cross the placental barrier more efficiently than other PFAS, and that mothers were ubiquitously exposed to PFOS and PFOA during the years 2003-2008. We found little evidence for an association between prenatal PFAS exposure and child health outcomes (i.e. fetal growth and preterm birth, obesity and cardiometabolic risk, and immune and respiratory health). Prospective studies with follow-ups beyond mid-childhood are recommended. |
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