Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases

Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of many key cellular events such as proliferation, differentiation, cell cycle regulation, migration, or apoptosis. To control these biological responses, GTPases activity is regulated by guanine nucleotide exchange...

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Autores: Arrazola Sastre, Alazne, Luque Montoro, Miriam, Gálvez Martín, Patricia, Lacerda, Hadriano M., Lucía Mulas, Alejandro, Llavero Bernal, Francisco, Zugaza Gurruchaga, José Luis
Tipo de documento: artigo
Data de publicação:2020
País:España
Recursos:Universidad del País Vasco
Repositório:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/46290
Acesso em linha:http://hdl.handle.net/10810/46290
Access Level:Acceso aberto
Palavra-chave:GTPases
neurodegeneration
Alzheimer
Parkinson
Ras
Rap
Rho
Rac
Cdc42
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spelling Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative DiseasesArrazola Sastre, AlazneLuque Montoro, MiriamGálvez Martín, PatriciaLacerda, Hadriano M.Lucía Mulas, AlejandroLlavero Bernal, FranciscoZugaza Gurruchaga, José LuisGTPasesneurodegenerationAlzheimerParkinsonRasRapRhoRacCdc42Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of many key cellular events such as proliferation, differentiation, cell cycle regulation, migration, or apoptosis. To control these biological responses, GTPases activity is regulated by guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs), and in some small GTPases also guanine nucleotide dissociation inhibitors (GDIs). Moreover, small GTPases transduce signals by their downstream effector molecules. Many studies demonstrate that small GTPases of the Ras family are involved in neurodegeneration processes. Here, in this review, we focus on the signaling pathways controlled by these small protein superfamilies that culminate in neurodegenerative pathologies, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Specifically, we concentrate on the two most studied families of the Ras superfamily: the Ras and Rho families. We summarize the latest findings of small GTPases of the Ras and Rho families in neurodegeneration in order to highlight these small proteins as potential therapeutic targets capable of slowing down different neurodegenerative diseases.A.A.S. is a recipient of a predoctoral fellowship (PRE_2017_1_0016) from the Basque Government. M.L.M. is a recipient of a fellowship from Foundation “Jesús de Gangoiti y Barrera”. J.L.Z. was supported by the Instituto de Salud Carlos III (PI18/00207) and the University of Basque Country Grant (US19/04)http://creativecommons.org/licenses/by/3.0/es/MDPI2020202020202020info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/46290reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.mdpi.com/1422-0067/21/17/6312info:eu-repo/semantics/openAccess2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).oai:addi.ehu.eus:10810/462902026-06-18T09:23:17Z
dc.title.none.fl_str_mv Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases
title Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases
spellingShingle Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases
Arrazola Sastre, Alazne
GTPases
neurodegeneration
Alzheimer
Parkinson
Ras
Rap
Rho
Rac
Cdc42
title_short Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases
title_full Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases
title_fullStr Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases
title_full_unstemmed Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases
title_sort Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases
dc.creator.none.fl_str_mv Arrazola Sastre, Alazne
Luque Montoro, Miriam
Gálvez Martín, Patricia
Lacerda, Hadriano M.
Lucía Mulas, Alejandro
Llavero Bernal, Francisco
Zugaza Gurruchaga, José Luis
author Arrazola Sastre, Alazne
author_facet Arrazola Sastre, Alazne
Luque Montoro, Miriam
Gálvez Martín, Patricia
Lacerda, Hadriano M.
Lucía Mulas, Alejandro
Llavero Bernal, Francisco
Zugaza Gurruchaga, José Luis
author_role author
author2 Luque Montoro, Miriam
Gálvez Martín, Patricia
Lacerda, Hadriano M.
Lucía Mulas, Alejandro
Llavero Bernal, Francisco
Zugaza Gurruchaga, José Luis
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv GTPases
neurodegeneration
Alzheimer
Parkinson
Ras
Rap
Rho
Rac
Cdc42
topic GTPases
neurodegeneration
Alzheimer
Parkinson
Ras
Rap
Rho
Rac
Cdc42
description Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of many key cellular events such as proliferation, differentiation, cell cycle regulation, migration, or apoptosis. To control these biological responses, GTPases activity is regulated by guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs), and in some small GTPases also guanine nucleotide dissociation inhibitors (GDIs). Moreover, small GTPases transduce signals by their downstream effector molecules. Many studies demonstrate that small GTPases of the Ras family are involved in neurodegeneration processes. Here, in this review, we focus on the signaling pathways controlled by these small protein superfamilies that culminate in neurodegenerative pathologies, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Specifically, we concentrate on the two most studied families of the Ras superfamily: the Ras and Rho families. We summarize the latest findings of small GTPases of the Ras and Rho families in neurodegeneration in order to highlight these small proteins as potential therapeutic targets capable of slowing down different neurodegenerative diseases.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/46290
url http://hdl.handle.net/10810/46290
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/1422-0067/21/17/6312
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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