Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure

Excess aldosterone promotes pathological remodeling of the heart and imbalance in cardiac ion homeostasis of sodium, potassium and calcium. Novel treatment with proanthocyanidins in aldosterone-treated rats has resulted in downregulation of cardiac SGK1, the main genomic aldosterone-induced intracel...

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Autores: Heras Jiménez, Natalia De Las, Galiana, Adrián, Ballesteros Rodrigálvarez, Sandra, Olivares Álvaro, Elena, Fuller, Peter J., Lahera Julia, Vicente, Martín Fernández, Beatriz, Ballesteros Rodrigálvarez, Sandra María
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/4841
Acesso em linha:https://hdl.handle.net/20.500.14352/4841
Access Level:acceso abierto
Palavra-chave:Hypertension
Cardiac hypertrophy
Proanthocyanidins
Ion homeostasis
Cardiología
Fisiología
3205.01 Cardiología
2411 Fisiología Humana
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spelling Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart FailureHeras Jiménez, Natalia De LasGaliana, AdriánBallesteros Rodrigálvarez, SandraOlivares Álvaro, ElenaFuller, Peter J.Lahera Julia, VicenteMartín Fernández, BeatrizBallesteros Rodrigálvarez, Sandra MaríaHypertensionCardiac hypertrophyProanthocyanidinsIon homeostasisCardiologíaFisiología3205.01 Cardiología2411 Fisiología HumanaExcess aldosterone promotes pathological remodeling of the heart and imbalance in cardiac ion homeostasis of sodium, potassium and calcium. Novel treatment with proanthocyanidins in aldosterone-treated rats has resulted in downregulation of cardiac SGK1, the main genomic aldosterone-induced intracellular mediator of ion handling. It therefore follows that proanthocyanidins could be modulating cardiac ion homeostasis in aldosterone-treated rats. Male Wistar rats received aldosterone (1 mg kg−1 day−1) +1% NaCl for three weeks. Half of the animals in each group were simultaneously treated with the proanthocyanidins-rich extract (80% w/w) (PRO80, 5 mg kg−1 day−1). PRO80 prevented cardiac hypertrophy and decreased calcium content. Expression of ion channels (ROMK, NHE1, NKA and NCX1) and calcium transient mediators (CAV1.2, pCaMKII and oxCaMKII) were reduced by PRO80 treatment in aldosterone-treated rats. To conclude, our data indicate that PRO80 may offer an alternative treatment to conventional MR-blockade in the prevention of aldosterone-induced cardiac pathology.MPDIUniversidad Complutense de Madrid20212021-09-0420212021-09-04journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/4841reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/48412026-06-02T12:44:21Z
dc.title.none.fl_str_mv Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure
title Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure
spellingShingle Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure
Heras Jiménez, Natalia De Las
Hypertension
Cardiac hypertrophy
Proanthocyanidins
Ion homeostasis
Cardiología
Fisiología
3205.01 Cardiología
2411 Fisiología Humana
title_short Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure
title_full Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure
title_fullStr Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure
title_full_unstemmed Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure
title_sort Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure
dc.creator.none.fl_str_mv Heras Jiménez, Natalia De Las
Galiana, Adrián
Ballesteros Rodrigálvarez, Sandra
Olivares Álvaro, Elena
Fuller, Peter J.
Lahera Julia, Vicente
Martín Fernández, Beatriz
Ballesteros Rodrigálvarez, Sandra María
author Heras Jiménez, Natalia De Las
author_facet Heras Jiménez, Natalia De Las
Galiana, Adrián
Ballesteros Rodrigálvarez, Sandra
Olivares Álvaro, Elena
Fuller, Peter J.
Lahera Julia, Vicente
Martín Fernández, Beatriz
Ballesteros Rodrigálvarez, Sandra María
author_role author
author2 Galiana, Adrián
Ballesteros Rodrigálvarez, Sandra
Olivares Álvaro, Elena
Fuller, Peter J.
Lahera Julia, Vicente
Martín Fernández, Beatriz
Ballesteros Rodrigálvarez, Sandra María
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Hypertension
Cardiac hypertrophy
Proanthocyanidins
Ion homeostasis
Cardiología
Fisiología
3205.01 Cardiología
2411 Fisiología Humana
topic Hypertension
Cardiac hypertrophy
Proanthocyanidins
Ion homeostasis
Cardiología
Fisiología
3205.01 Cardiología
2411 Fisiología Humana
description Excess aldosterone promotes pathological remodeling of the heart and imbalance in cardiac ion homeostasis of sodium, potassium and calcium. Novel treatment with proanthocyanidins in aldosterone-treated rats has resulted in downregulation of cardiac SGK1, the main genomic aldosterone-induced intracellular mediator of ion handling. It therefore follows that proanthocyanidins could be modulating cardiac ion homeostasis in aldosterone-treated rats. Male Wistar rats received aldosterone (1 mg kg−1 day−1) +1% NaCl for three weeks. Half of the animals in each group were simultaneously treated with the proanthocyanidins-rich extract (80% w/w) (PRO80, 5 mg kg−1 day−1). PRO80 prevented cardiac hypertrophy and decreased calcium content. Expression of ion channels (ROMK, NHE1, NKA and NCX1) and calcium transient mediators (CAV1.2, pCaMKII and oxCaMKII) were reduced by PRO80 treatment in aldosterone-treated rats. To conclude, our data indicate that PRO80 may offer an alternative treatment to conventional MR-blockade in the prevention of aldosterone-induced cardiac pathology.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-09-04
2021
2021-09-04
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/4841
url https://hdl.handle.net/20.500.14352/4841
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MPDI
publisher.none.fl_str_mv MPDI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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