Determinants and functions of CAFs secretome during cancer progression and therapy

Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represen...

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Detalles Bibliográficos
Autores: Linares Aceituno, Jenniffer Lissethe, Marín Jiménez, Juan A., Badia-Ramentol, Jordi, Calon, Alexandre
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/47877
Acceso en línea:http://hdl.handle.net/10230/47877
http://dx.doi.org/10.3389/fcell.2020.621070
Access Level:acceso abierto
Palabra clave:Cancer
Cancer-associated fibroblast (CAF)
Growth factors
Metastasis
Secreted factors
Secretome
Therapy
Tumor microenvironment (TME)
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spelling Determinants and functions of CAFs secretome during cancer progression and therapyLinares Aceituno, Jenniffer LissetheMarín Jiménez, Juan A.Badia-Ramentol, JordiCalon, AlexandreCancerCancer-associated fibroblast (CAF)Growth factorsMetastasisSecreted factorsSecretomeTherapyTumor microenvironment (TME)Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represented in the TME and are continuously interacting with cancer cells. CAFs are regulating key mechanisms during progression to metastasis and response to treatment by enhancing cancer cells survival and aggressiveness. The latest advances in CAFs biology are pointing to CAFs-secreted factors as druggable targets and companion tools for cancer diagnosis and prognosis. Especially, extensive research conducted in the recent years has underscored the potential of several cytokines as actionable biomarkers that are currently evaluated in the clinical setting. In this review, we explore the current understanding of CAFs secretome determinants and functions to discuss their clinical implication in oncology.Frontiers202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/47877http://dx.doi.org/10.3389/fcell.2020.621070reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésFront Cell Dev Biol. 2021;8:621070© 2021 Linares, Marín-Jiménez, Badia-Ramentol and Calon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/478772026-06-12T07:21:37Z
dc.title.none.fl_str_mv Determinants and functions of CAFs secretome during cancer progression and therapy
title Determinants and functions of CAFs secretome during cancer progression and therapy
spellingShingle Determinants and functions of CAFs secretome during cancer progression and therapy
Linares Aceituno, Jenniffer Lissethe
Cancer
Cancer-associated fibroblast (CAF)
Growth factors
Metastasis
Secreted factors
Secretome
Therapy
Tumor microenvironment (TME)
title_short Determinants and functions of CAFs secretome during cancer progression and therapy
title_full Determinants and functions of CAFs secretome during cancer progression and therapy
title_fullStr Determinants and functions of CAFs secretome during cancer progression and therapy
title_full_unstemmed Determinants and functions of CAFs secretome during cancer progression and therapy
title_sort Determinants and functions of CAFs secretome during cancer progression and therapy
dc.creator.none.fl_str_mv Linares Aceituno, Jenniffer Lissethe
Marín Jiménez, Juan A.
Badia-Ramentol, Jordi
Calon, Alexandre
author Linares Aceituno, Jenniffer Lissethe
author_facet Linares Aceituno, Jenniffer Lissethe
Marín Jiménez, Juan A.
Badia-Ramentol, Jordi
Calon, Alexandre
author_role author
author2 Marín Jiménez, Juan A.
Badia-Ramentol, Jordi
Calon, Alexandre
author2_role author
author
author
dc.subject.none.fl_str_mv Cancer
Cancer-associated fibroblast (CAF)
Growth factors
Metastasis
Secreted factors
Secretome
Therapy
Tumor microenvironment (TME)
topic Cancer
Cancer-associated fibroblast (CAF)
Growth factors
Metastasis
Secreted factors
Secretome
Therapy
Tumor microenvironment (TME)
description Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represented in the TME and are continuously interacting with cancer cells. CAFs are regulating key mechanisms during progression to metastasis and response to treatment by enhancing cancer cells survival and aggressiveness. The latest advances in CAFs biology are pointing to CAFs-secreted factors as druggable targets and companion tools for cancer diagnosis and prognosis. Especially, extensive research conducted in the recent years has underscored the potential of several cytokines as actionable biomarkers that are currently evaluated in the clinical setting. In this review, we explore the current understanding of CAFs secretome determinants and functions to discuss their clinical implication in oncology.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/47877
http://dx.doi.org/10.3389/fcell.2020.621070
url http://hdl.handle.net/10230/47877
http://dx.doi.org/10.3389/fcell.2020.621070
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Front Cell Dev Biol. 2021;8:621070
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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