Amorphous Solid Dispersion of a Binary Formulation with Felodipine and HPMC for 3D Printed Floating Tablets

This study focuses on the combination of three-dimensional printing (3DP) and amorphous solid dispersion (ASD) technologies for the manufacturing of gastroretentive floating tablets. Employing hot melt extrusion (HME) and fused deposition modeling (FDM), the study investigates the development of dru...

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Autores: Mora Castaño, Gloria, Millán Jiménez, Mónica, Niederquell, Andreas, Schonenberger, Monica, Shojaie, Fatemeh, Kuentz, Martin, Caraballo Rodríguez, Isidoro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/165146
Acceso en línea:https://hdl.handle.net/11441/165146
https://doi.org/10.1016/j.ijpharm.2024.124215
Access Level:acceso abierto
Palabra clave:3D printing
Amorphous solid dispersion
Drug-loaded filaments
Fused deposition modeling
Gastroretentive floating tablets
Zero-order release
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spelling Amorphous Solid Dispersion of a Binary Formulation with Felodipine and HPMC for 3D Printed Floating TabletsMora Castaño, GloriaMillán Jiménez, MónicaNiederquell, AndreasSchonenberger, MonicaShojaie, FatemehKuentz, MartinCaraballo Rodríguez, Isidoro3D printingAmorphous solid dispersionDrug-loaded filamentsFused deposition modelingGastroretentive floating tabletsZero-order releaseThis study focuses on the combination of three-dimensional printing (3DP) and amorphous solid dispersion (ASD) technologies for the manufacturing of gastroretentive floating tablets. Employing hot melt extrusion (HME) and fused deposition modeling (FDM), the study investigates the development of drug-loaded filaments and 3D printed (3DP) tablets containing felodipine as model drug and hydroxypropyl methylcellulose (HPMC) as the polymeric carrier. Prior to fabrication, solubility parameter estimation and molecular dynamics simulations were applied to predict drug-polymer interactions, which are crucial for ASD formation. Physical bulk and surface characterization complemented the quality control of both drug-loaded filaments and 3DP tablets. The analysis confirmed a successful amorphous dispersion of felodipine within the polymeric matrix. Furthermore, the low infill percentage and enclosed design of the 3DP tablet allowed for obtaining low-density systems. This structure resulted in buoyancy during the entire drug release process until a complete dissolution of the 3DP tablets (more than 8 h) was attained. The particular design made it possible for a single polymer to achieve a zero-order controlled release of the drug, which is considered the ideal kinetics for a gastroretentive system. Accordingly, this study can be seen as an advancement in ASD formulation for 3DP technology within pharmaceutics.Ministerio de Ciencia e Innovación RTI2018-095041-B-C31Junta de Andalucía US-1380923Ministerio de Ciencia, Innovación y Universidades FPU18/05665, EST22/00038Premio Mensual Publicación Científica Destacada de la US. Facultad de FarmaciaElsevierFarmacia y Tecnología FarmacéuticaMinisterio de Ciencia e Innovación (MICIN). EspañaJunta de AndalucíaMinisterio de Ciencia, Innovación y Universidades (MICINN). España2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/165146https://doi.org/10.1016/j.ijpharm.2024.124215reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInternational Journal of Pharmaceutics, 658, 124215.RTI2018-095041-B-C31US-1380923FPU18/05665EST22/00038https://doi.org/10.1016/j.ijpharm.2024.124215info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1651462026-06-17T12:51:07Z
dc.title.none.fl_str_mv Amorphous Solid Dispersion of a Binary Formulation with Felodipine and HPMC for 3D Printed Floating Tablets
title Amorphous Solid Dispersion of a Binary Formulation with Felodipine and HPMC for 3D Printed Floating Tablets
spellingShingle Amorphous Solid Dispersion of a Binary Formulation with Felodipine and HPMC for 3D Printed Floating Tablets
Mora Castaño, Gloria
3D printing
Amorphous solid dispersion
Drug-loaded filaments
Fused deposition modeling
Gastroretentive floating tablets
Zero-order release
title_short Amorphous Solid Dispersion of a Binary Formulation with Felodipine and HPMC for 3D Printed Floating Tablets
title_full Amorphous Solid Dispersion of a Binary Formulation with Felodipine and HPMC for 3D Printed Floating Tablets
title_fullStr Amorphous Solid Dispersion of a Binary Formulation with Felodipine and HPMC for 3D Printed Floating Tablets
title_full_unstemmed Amorphous Solid Dispersion of a Binary Formulation with Felodipine and HPMC for 3D Printed Floating Tablets
title_sort Amorphous Solid Dispersion of a Binary Formulation with Felodipine and HPMC for 3D Printed Floating Tablets
dc.creator.none.fl_str_mv Mora Castaño, Gloria
Millán Jiménez, Mónica
Niederquell, Andreas
Schonenberger, Monica
Shojaie, Fatemeh
Kuentz, Martin
Caraballo Rodríguez, Isidoro
author Mora Castaño, Gloria
author_facet Mora Castaño, Gloria
Millán Jiménez, Mónica
Niederquell, Andreas
Schonenberger, Monica
Shojaie, Fatemeh
Kuentz, Martin
Caraballo Rodríguez, Isidoro
author_role author
author2 Millán Jiménez, Mónica
Niederquell, Andreas
Schonenberger, Monica
Shojaie, Fatemeh
Kuentz, Martin
Caraballo Rodríguez, Isidoro
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Farmacia y Tecnología Farmacéutica
Ministerio de Ciencia e Innovación (MICIN). España
Junta de Andalucía
Ministerio de Ciencia, Innovación y Universidades (MICINN). España
dc.subject.none.fl_str_mv 3D printing
Amorphous solid dispersion
Drug-loaded filaments
Fused deposition modeling
Gastroretentive floating tablets
Zero-order release
topic 3D printing
Amorphous solid dispersion
Drug-loaded filaments
Fused deposition modeling
Gastroretentive floating tablets
Zero-order release
description This study focuses on the combination of three-dimensional printing (3DP) and amorphous solid dispersion (ASD) technologies for the manufacturing of gastroretentive floating tablets. Employing hot melt extrusion (HME) and fused deposition modeling (FDM), the study investigates the development of drug-loaded filaments and 3D printed (3DP) tablets containing felodipine as model drug and hydroxypropyl methylcellulose (HPMC) as the polymeric carrier. Prior to fabrication, solubility parameter estimation and molecular dynamics simulations were applied to predict drug-polymer interactions, which are crucial for ASD formation. Physical bulk and surface characterization complemented the quality control of both drug-loaded filaments and 3DP tablets. The analysis confirmed a successful amorphous dispersion of felodipine within the polymeric matrix. Furthermore, the low infill percentage and enclosed design of the 3DP tablet allowed for obtaining low-density systems. This structure resulted in buoyancy during the entire drug release process until a complete dissolution of the 3DP tablets (more than 8 h) was attained. The particular design made it possible for a single polymer to achieve a zero-order controlled release of the drug, which is considered the ideal kinetics for a gastroretentive system. Accordingly, this study can be seen as an advancement in ASD formulation for 3DP technology within pharmaceutics.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/165146
https://doi.org/10.1016/j.ijpharm.2024.124215
url https://hdl.handle.net/11441/165146
https://doi.org/10.1016/j.ijpharm.2024.124215
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Pharmaceutics, 658, 124215.
RTI2018-095041-B-C31
US-1380923
FPU18/05665
EST22/00038
https://doi.org/10.1016/j.ijpharm.2024.124215
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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