Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging

Diseases and aging-associated alterations of the nervous system often show sex-specific characteristics. Glial cells play a major role in the endogenous homeostatic response of neural tissue, and sex differences in the glial transcriptome and function have been described. Therefore, the possible rol...

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Detalhes bibliográficos
Autores: Chowen, Julie A., García-Segura, Luis M.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/259954
Acesso em linha:http://hdl.handle.net/10261/259954
Access Level:acceso abierto
Palavra-chave:Astrocytes
Microglia
Myelin
Neuroactive steroids
Sex chromosomes
Steroid receptors.
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spelling Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain agingChowen, Julie A.García-Segura, Luis M.AstrocytesMicrogliaMyelinNeuroactive steroidsSex chromosomesSteroid receptors.Diseases and aging-associated alterations of the nervous system often show sex-specific characteristics. Glial cells play a major role in the endogenous homeostatic response of neural tissue, and sex differences in the glial transcriptome and function have been described. Therefore, the possible role of these cells in the generation of sex differences in pathological alterations of the nervous system is reviewed here. Studies have shown that glia react to pathological insults with sex-specific neuroprotective and regenerative effects. At least three factors determine this sex-specific response of glia: sex chromosome genes, gonadal hormones and neuroactive steroid hormone metabolites. The sex chromosome complement determines differences in the transcriptional responses in glia after brain injury, while gonadal hormones and their metabolites activate sex-specific neuroprotective mechanisms in these cells. Since the sex-specific neuroprotective and regenerative activity of glial cells causes sex differences in the pathological alterations of the nervous system, glia may represent a relevant target for sex-specific therapeutic interventions.We acknowledge support from CIBEROBN, CIBERFES, Fondo de Investigación Sanitaria (PI1900166), Agencia Estatal de Investigación, Ministerio de Ciencia e Innovación (BFU2017-82565-C21-R2; BFU2017-82754-R) and Fondo Europeo de Desarrollo Regional (FEDER). Funding sources were not involved in any step of the design and preparation of this article, including the decision to submit it for publication.Elsevier BVCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España)Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (España)Agencia Estatal de Investigación (España)Ministerio de Ciencia e Innovación (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/259954reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-82565-C2-1-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-82754-Rhttp://dx.doi.org/10.1016/j.mad.2021.111473Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2599542026-05-22T06:33:51Z
dc.title.none.fl_str_mv Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging
title Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging
spellingShingle Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging
Chowen, Julie A.
Astrocytes
Microglia
Myelin
Neuroactive steroids
Sex chromosomes
Steroid receptors.
title_short Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging
title_full Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging
title_fullStr Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging
title_full_unstemmed Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging
title_sort Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging
dc.creator.none.fl_str_mv Chowen, Julie A.
García-Segura, Luis M.
author Chowen, Julie A.
author_facet Chowen, Julie A.
García-Segura, Luis M.
author_role author
author2 García-Segura, Luis M.
author2_role author
dc.contributor.none.fl_str_mv Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España)
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (España)
Agencia Estatal de Investigación (España)
Ministerio de Ciencia e Innovación (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Astrocytes
Microglia
Myelin
Neuroactive steroids
Sex chromosomes
Steroid receptors.
topic Astrocytes
Microglia
Myelin
Neuroactive steroids
Sex chromosomes
Steroid receptors.
description Diseases and aging-associated alterations of the nervous system often show sex-specific characteristics. Glial cells play a major role in the endogenous homeostatic response of neural tissue, and sex differences in the glial transcriptome and function have been described. Therefore, the possible role of these cells in the generation of sex differences in pathological alterations of the nervous system is reviewed here. Studies have shown that glia react to pathological insults with sex-specific neuroprotective and regenerative effects. At least three factors determine this sex-specific response of glia: sex chromosome genes, gonadal hormones and neuroactive steroid hormone metabolites. The sex chromosome complement determines differences in the transcriptional responses in glia after brain injury, while gonadal hormones and their metabolites activate sex-specific neuroprotective mechanisms in these cells. Since the sex-specific neuroprotective and regenerative activity of glial cells causes sex differences in the pathological alterations of the nervous system, glia may represent a relevant target for sex-specific therapeutic interventions.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/259954
url http://hdl.handle.net/10261/259954
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-82565-C2-1-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2017-82754-R
http://dx.doi.org/10.1016/j.mad.2021.111473
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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