Fish melanocortin system

31 p. Review

Detalles Bibliográficos
Autores: Cerdá-Reverter, José Miguel, Agulleiro Gozalbo, Maria Josep, Guillot, Raúl, Sánchez Martínez, Elisa, Ceinos, Rosa M., Rotllant, Josep
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/50051
Acceso en línea:http://hdl.handle.net/10261/50051
Access Level:acceso abierto
Palabra clave:Melanocortin-stimulating hormone (MSH)
Proopiomelanocortin
Agouti-signalling protein
Agouti-related protein (AGRP)
Melanocortin receptors
Melanocortin receptor accessory protein (MRAP)
Food intake
Pigmentation
Stress
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spelling Fish melanocortin systemCerdá-Reverter, José MiguelAgulleiro Gozalbo, Maria JosepGuillot, RaúlSánchez Martínez, ElisaCeinos, Rosa M.Rotllant, JosepMelanocortin-stimulating hormone (MSH)ProopiomelanocortinAgouti-signalling proteinAgouti-related protein (AGRP)Melanocortin receptorsMelanocortin receptor accessory protein (MRAP)Food intakePigmentationStress31 p. ReviewMelanocortin signalling is mediated by binding to a family of G protein-coupled receptors that positively couple to adenylyl cyclase. Tetrapod species have five melanocortin (MC1-MC5) receptors. The number of receptors varies in fish, zebrafish, for example, having six melanocortin receptors, with two copies of the melanocortin MC5 receptor, while pufferfish have 4 receptors with no melanocortin MC3 receptor and one copy of melanocortin MC5 receptor. Fish genomes also exhibit orthologue genes for agouti-signalling protein (ASP) and -related protein (AGRP). AGRP expression is confined to a small area in the hypothalamus but ASP is expressed in the skin. Fish melanocortin MC2 receptor is specific for ACTH and requires the cooperation of accessory proteins (MRAP) to reach functional expression. The four other melanocortin MC receptors distinctively bind MSHs. The interaction of α-MSH and melanocortin MC 1 receptor plays a key point in the control of the pigmentation and mutations of melanocortin MC1 receptor are responsible for reduced melanization. Both melanocortin MC4 and MC5 receptor are expressed in the hypothalamus, and central melanocortin MC4 receptor expression is thought to regulate the energy balance through the modulation of feeding behaviour. In addition, the peripheral melanocortin system also regulates lipid metabolism by acting at hepatic melanocortin MC2 and MC5 receptors. Both sea bass melanocortin MC1 and MC 4 receptors are constitutively expressed in vitro and both ASP and AGRP work as inverse agonists but only after inhibition of the phosphodiesterase system. Accordingly, the overexpression of AGRP and ASP transgenes promotes obesity and reduces melanization in zebrafish, respectively.This work was partially supported by grants from the Ministry of Science and Innovation (MICINN) AGL2007-65744-C03-02, CSD 2007-00002 and AGL2010-22247-C03-01 to JM C-R. MJA is recipient of a “Juan de la Cierva” research contract (2009) from the Spanish Science and Innovation Ministry.Peer reviewedElsevier201220122011info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/50051reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.ejphar.2010.10.108info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/500512026-05-22T06:33:51Z
dc.title.none.fl_str_mv Fish melanocortin system
title Fish melanocortin system
spellingShingle Fish melanocortin system
Cerdá-Reverter, José Miguel
Melanocortin-stimulating hormone (MSH)
Proopiomelanocortin
Agouti-signalling protein
Agouti-related protein (AGRP)
Melanocortin receptors
Melanocortin receptor accessory protein (MRAP)
Food intake
Pigmentation
Stress
title_short Fish melanocortin system
title_full Fish melanocortin system
title_fullStr Fish melanocortin system
title_full_unstemmed Fish melanocortin system
title_sort Fish melanocortin system
dc.creator.none.fl_str_mv Cerdá-Reverter, José Miguel
Agulleiro Gozalbo, Maria Josep
Guillot, Raúl
Sánchez Martínez, Elisa
Ceinos, Rosa M.
Rotllant, Josep
author Cerdá-Reverter, José Miguel
author_facet Cerdá-Reverter, José Miguel
Agulleiro Gozalbo, Maria Josep
Guillot, Raúl
Sánchez Martínez, Elisa
Ceinos, Rosa M.
Rotllant, Josep
author_role author
author2 Agulleiro Gozalbo, Maria Josep
Guillot, Raúl
Sánchez Martínez, Elisa
Ceinos, Rosa M.
Rotllant, Josep
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Melanocortin-stimulating hormone (MSH)
Proopiomelanocortin
Agouti-signalling protein
Agouti-related protein (AGRP)
Melanocortin receptors
Melanocortin receptor accessory protein (MRAP)
Food intake
Pigmentation
Stress
topic Melanocortin-stimulating hormone (MSH)
Proopiomelanocortin
Agouti-signalling protein
Agouti-related protein (AGRP)
Melanocortin receptors
Melanocortin receptor accessory protein (MRAP)
Food intake
Pigmentation
Stress
description 31 p. Review
publishDate 2011
dc.date.none.fl_str_mv 2011
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/50051
url http://hdl.handle.net/10261/50051
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.ejphar.2010.10.108
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405312395509760
score 15,811543

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