A multicenter case-control study of the effect of e-nos VNTR polymorphism on upper gastrointestinal hemorrhage in NSAID users

Bleeding in non-steroidal anti-inflammatory drug (NSAID) users limited their prescription. This first multicenter full case-control study (325 cases and 744 controls), explored the association of e-NOS intron 4 variable number tandem repeat (VNTR) polymorphism with upper gastrointestinal hemorrhage...

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Detalles Bibliográficos
Autores: Mallah, Narmeen, Zapata-Cachafeiro, Maruxa, Ibarra-García, Eguzkiñe, Palacios-Zabalza, Itziar, Macías García, Fernando, Iglesias García, Júlio, Piñeiro-Lamas, María, Ibáñez, Luisa|||0000-0002-1175-0574, Vidal Guitart, Xavier|||0000-0001-6705-4298, Vendrell Bosch, Lourdes, Martin-Arias, Luís, Sáinz Gil, María, Salgado Barreira, Ángel, Figueiras, Adolfo
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:293190
Acceso en línea:https://ddd.uab.cat/record/293190
https://dx.doi.org/urn:doi:10.1038/s41598-021-99402-w
Access Level:acceso abierto
Palabra clave:Adult
Aged
Alleles
Anti-Inflammatory Agents, Non-Steroidal
Case-Control Studies
Disease Susceptibility
Female
Gastrointestinal Hemorrhage
Genetic Predisposition to Disease
Genotype
Humans
Introns
Male
Middle Aged
Minisatellite Repeats
Nitric Oxide Synthase Type III
Polymorphism, Genetic
Risk Factors
Descripción
Sumario:Bleeding in non-steroidal anti-inflammatory drug (NSAID) users limited their prescription. This first multicenter full case-control study (325 cases and 744 controls), explored the association of e-NOS intron 4 variable number tandem repeat (VNTR) polymorphism with upper gastrointestinal hemorrhage (UGIH) in NSAID exposed and unexposed populations and assessed any interaction between this polymorphism and NSAIDs. NSAID users carrying e-NOS intron 4 wild type genotype or VNTR polymorphism have higher odds of UGIH than those unexposed to NSAIDs [Odds Ratio (OR): 6.62 (95% Confidence Interval (CI): 4.24, 10.36) and OR: 5.41 (95% CI 2.62, 11.51), respectively], with no effect modification from VNTR polymorphism-NSAIDs interaction [Relative Excess Risk due to Interaction (RERI): -1.35 (95% CI -5.73, 3.03); Synergism Index (S): 0.77 (95% CI 0.31, 1.94)]. Similar findings were obtained for aspirin exposure. Non-aspirin NSAID users who carry e-NOS intron 4 VNTR polymorphism have lower odds of UGIH [OR: 4.02 (95% CI 1.85, 8.75) than those users with wild type genotype [OR: 6.52 (95% CI 4.09, 10.38)]; though the interaction estimates are not statistically significant [RERI: -2.68 (95% CI -6.67, 1.31); S: 0.53 (95% CI 0.18, 1.55)]. This exploratory study suggests that the odds of UGIH in NSAID or aspirin users does not modify according to patient's e-NOS intron 4 genotype.

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