Thermal profiles for focal pulsed electric field ablation

Background. Pulsed electrical field (PEF) ablation may cause tissue heating. These changes are reportedly small, but each PEF system and waveform will have a different behavior, and data are lacking. Objectives. This study sought to compare the temperature profile of focal point, monopolar biphasic...

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Autores: Verma, Atul, Zhong, Princeton, Castellví Fernández, Quim, Girouard, Steve, Mediratta MSBME, Vik, Neal, Robert E.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/70212
Acceso en línea:http://hdl.handle.net/10230/70212
http://dx.doi.org/10.1016/j.jacep.2023.05.005
Access Level:acceso abierto
Palabra clave:Ablation
Cardiac
CENTAURI
Profile
Pulsed electrical fields
Temperature
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spelling Thermal profiles for focal pulsed electric field ablationVerma, Atul Zhong, PrincetonCastellví Fernández, QuimGirouard, SteveMediratta MSBME, VikNeal, Robert E.AblationCardiacCENTAURIProfilePulsed electrical fieldsTemperatureBackground. Pulsed electrical field (PEF) ablation may cause tissue heating. These changes are reportedly small, but each PEF system and waveform will have a different behavior, and data are lacking. Objectives. This study sought to compare the temperature profile of focal point, monopolar biphasic PEF ablation versus radiofrequency (RF). Methods. Ablation lesions were performed on perfused thigh muscle of swine. PEF lesions were performed with 3 compatible ablation catheters at the highest (25 amp) energy, and 1 catheter (Tacticath SE) was also used at the 22- and 19-amp levels. Temperature changes in the tissue were measured using fluoroptic temperature probes inserted at the muscle surface, as well as 3 mm and 7 mm below the surface. Temperatures were recorded continuously at baseline, during delivery, and after ablation. Muscle temperatures were compared with those of RF lesions performed with 1 catheter (Tacticath SE) at 30 W for 30 seconds. Results. PEF ablation with 3energy settings produced small temperature changes. Maximum average temperature rise for PEF for the maximum (25-amp) energy setting (32 lesions) was 7.6 °C, 2.8 °C, and 0.9 °C at the surface, 3-mm depth, and 7-mm depth, respectively. The temperature rise was dose dependent, with lower energy settings yielding less temperature rise. RF ablations (10 lesions) produced temperature increases of 16.6 °C, 39.8 °C, and 9.5 °C at the surface, 3-mm depth, and 7-mm depth, respectively. Conclusions. PEF caused detectable temperature changes in muscle tissue, which never exceeded 2.8 °C at the 3-mm depth versus baseline. By contrast, RF produced substantial temperature rises. These data support that focal monopolar biphasic energy delivered by this PEF technology retains a favorable thermal safety profile.Elsevier202520252023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/70212http://dx.doi.org/10.1016/j.jacep.2023.05.005reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésJACC: Clinical Electrophysiology. 2023 Sep;9(9):1854-63© 2023 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/702122026-06-12T07:21:37Z
dc.title.none.fl_str_mv Thermal profiles for focal pulsed electric field ablation
title Thermal profiles for focal pulsed electric field ablation
spellingShingle Thermal profiles for focal pulsed electric field ablation
Verma, Atul
Ablation
Cardiac
CENTAURI
Profile
Pulsed electrical fields
Temperature
title_short Thermal profiles for focal pulsed electric field ablation
title_full Thermal profiles for focal pulsed electric field ablation
title_fullStr Thermal profiles for focal pulsed electric field ablation
title_full_unstemmed Thermal profiles for focal pulsed electric field ablation
title_sort Thermal profiles for focal pulsed electric field ablation
dc.creator.none.fl_str_mv Verma, Atul
Zhong, Princeton
Castellví Fernández, Quim
Girouard, Steve
Mediratta MSBME, Vik
Neal, Robert E.
author Verma, Atul
author_facet Verma, Atul
Zhong, Princeton
Castellví Fernández, Quim
Girouard, Steve
Mediratta MSBME, Vik
Neal, Robert E.
author_role author
author2 Zhong, Princeton
Castellví Fernández, Quim
Girouard, Steve
Mediratta MSBME, Vik
Neal, Robert E.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ablation
Cardiac
CENTAURI
Profile
Pulsed electrical fields
Temperature
topic Ablation
Cardiac
CENTAURI
Profile
Pulsed electrical fields
Temperature
description Background. Pulsed electrical field (PEF) ablation may cause tissue heating. These changes are reportedly small, but each PEF system and waveform will have a different behavior, and data are lacking. Objectives. This study sought to compare the temperature profile of focal point, monopolar biphasic PEF ablation versus radiofrequency (RF). Methods. Ablation lesions were performed on perfused thigh muscle of swine. PEF lesions were performed with 3 compatible ablation catheters at the highest (25 amp) energy, and 1 catheter (Tacticath SE) was also used at the 22- and 19-amp levels. Temperature changes in the tissue were measured using fluoroptic temperature probes inserted at the muscle surface, as well as 3 mm and 7 mm below the surface. Temperatures were recorded continuously at baseline, during delivery, and after ablation. Muscle temperatures were compared with those of RF lesions performed with 1 catheter (Tacticath SE) at 30 W for 30 seconds. Results. PEF ablation with 3energy settings produced small temperature changes. Maximum average temperature rise for PEF for the maximum (25-amp) energy setting (32 lesions) was 7.6 °C, 2.8 °C, and 0.9 °C at the surface, 3-mm depth, and 7-mm depth, respectively. The temperature rise was dose dependent, with lower energy settings yielding less temperature rise. RF ablations (10 lesions) produced temperature increases of 16.6 °C, 39.8 °C, and 9.5 °C at the surface, 3-mm depth, and 7-mm depth, respectively. Conclusions. PEF caused detectable temperature changes in muscle tissue, which never exceeded 2.8 °C at the 3-mm depth versus baseline. By contrast, RF produced substantial temperature rises. These data support that focal monopolar biphasic energy delivered by this PEF technology retains a favorable thermal safety profile.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/70212
http://dx.doi.org/10.1016/j.jacep.2023.05.005
url http://hdl.handle.net/10230/70212
http://dx.doi.org/10.1016/j.jacep.2023.05.005
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv JACC: Clinical Electrophysiology. 2023 Sep;9(9):1854-63
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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