Effects of morphine on tumour growth

Endogenous opiate alkaloids, such as morphine, and their peptide counterparts have been implicated in a wide variety of pharmacological and physiological functions. In addition to their use in the treatment of pain, opioids, appears to be important in the growth regulation of normal and neoplastic t...

Descripción completa

Detalles Bibliográficos
Autores: Rasmussen, Mads, Zhu, Wei, Tonnesen, Jan, Cadet, P., Tonnesen, Else, Stefano, G. B.
Tipo de recurso: artículo
Fecha de publicación:2002
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/377401
Acceso en línea:http://hdl.handle.net/10261/377401
Access Level:acceso abierto
Palabra clave:Endogenous opioid
Morphine
Neoplasia
Cancer
Apoptosis
Nitric oxide
Descripción
Sumario:Endogenous opiate alkaloids, such as morphine, and their peptide counterparts have been implicated in a wide variety of pharmacological and physiological functions. In addition to their use in the treatment of pain, opioids, appears to be important in the growth regulation of normal and neoplastic tissue. This review will focus on the infl uence of endogenous and exogenous opioids on tumour growth, with emphasis on immunoregulatory and antiproliferative mechanisms.