Neodymium doped lanthanide fluoride nanoparticles as contrast agents for luminescent bioimaging and X-ray computed tomography
The synthesis of uniform neodymium-doped lanthanum trifluoride nanoparticles with lenticular shape and a mean diameter around 45 nm by using a homogeneous precipita- tion method is reported. The luminescent properties of the synthesized samples in terms of their emission spectra and emission lifetim...
| Authors: | , , , , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2022 |
| Country: | España |
| Institution: | Universidad de Sevilla (US) |
| Repository: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/137208 |
| Online Access: | https://hdl.handle.net/11441/137208 https://doi.org/10.1016/j.bsecv.2021.07.004 |
| Access Level: | Open access |
| Keyword: | Neodimio Fluoruro de lantano Nanopartículas Luminiscencia Tomografía computarizada Citotoxicidad Neodymium Lanthanum fluoride Nanoparticles Luminescence Computed tomography Cytotoxicity |
| Summary: | The synthesis of uniform neodymium-doped lanthanum trifluoride nanoparticles with lenticular shape and a mean diameter around 45 nm by using a homogeneous precipita- tion method is reported. The luminescent properties of the synthesized samples in terms of their emission spectra and emission lifetime are analyzed as a function of the Nd content to find the optimum phosphor and its suitability for luminescent imaging in the second bio- logical window. The X-ray attenuation properties of the optimum phosphor are evaluated to investigate their additional ability as contrast agent for X-ray computed tomography. Finally, the colloidal stability of the obtained nanoparticles in physiological medium and their cyto- toxicity are also analyzed to assess their aptness for in vivo bioimaging applications. |
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