Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis

Head and neck cancer (HNC) is a growing disease, affecting more than 700.000 cases per year and ranking as the sixth most prevalent type of cancer worldwide. The impossibility of properly entering into apoptosis directly influences uncontrolled growth and consequently tumor development and progressi...

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Autores: Silva, F.F.V.E., Caponio, V.C.A., Camolesi, G.C.V., Padin Iruegas, Maria Elena, Lorenzo Pouso, Alejandro Ismael, Lima, K.C., Vieira, S.L.S., Chamorro Petronacci, Cintia Micaela, Suárez Peñaranda, Jose Manuel, Pérez Sayáns, Mario
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21278
Acceso en línea:https://portalcientifico.sergas.gal//documentos/64860188a219857f1d78b6e9
http://hdl.handle.net/20.500.11940/21278
Access Level:acceso abierto
Palabra clave:Humans
Biomarkers, Tumor
Prognosis
Head and Neck Neoplasms
AS Santiago
IDIS
AS Pontevedra
AS Pontevedra AP
AS A Coruña
AS Coruña AP
CHUS
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spelling Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysisSilva, F.F.V.E.Caponio, V.C.A.Camolesi, G.C.V.Padin Iruegas, Maria ElenaLorenzo Pouso, Alejandro IsmaelLima, K.C.Vieira, S.L.S.Chamorro Petronacci, Cintia MicaelaSuárez Peñaranda, Jose ManuelPérez Sayáns, MarioHumansBiomarkers, TumorPrognosisHead and Neck NeoplasmsAS SantiagoIDISAS PontevedraAS Pontevedra APAS A CoruñaAS Coruña APAS SantiagoCHUSAS SantiagoIDISHead and neck cancer (HNC) is a growing disease, affecting more than 700.000 cases per year and ranking as the sixth most prevalent type of cancer worldwide. The impossibility of properly entering into apoptosis directly influences uncontrolled growth and consequently tumor development and progression. Bcl-2 emerged as a key regulator in the balance between cell apoptosis and proliferation in apoptosis machinery. This systematic review and meta-analysis aimed to review all published studies investigating changes in Bcl-2 protein expression assessed by immunohistochemistry (IHC) and related to prognostic and survival values of patients with HNC. After applying the inclusion and exclusion factors, we reached the number of 20 articles included in the meta-analysis. The random-effect pooled HR (CI95%) value of OS related to Bcl-2 IHC expression in tissues from HNC patients was 1.80 (CI95% 1.21-2.67) (p 0.0001) and DFS was 1.90 (CI95% 1.26-2.86 (p 0.0001). The OS value for the specific oral cavity tumors was 1.89 (1.34-2.67), while in the larynx it was 1.77 (0.62-5.06), and the DFS in the pharynx was 2.02 (1.46-2.79). The univariate and multivariate analyses of OS were respectively 1.43 (1.11-1.86) and 1.88 (1.12-3.16), while in DFS it was 1.70 (0.95-3.03) and 2.08 (1.55-2.80). The OS considering a low cut-off for Bcl-2 positivity was 1.19 (0.60-2.37) and DFS was 1.48 (0.91-2.41), while studies with a high cut-off demonstrated OS of 2.28 (1.47-3.52) and DFS of 2.77 (1.74-4.40). Our meta-analysis demonstrates that Bcl-2 protein overexpression can result in worse LNM, OS, and DFS in patients with HNC, however, it is not a reliable conclusion, due to the wide divergences between the original studies and the fact that many studies have a very high range of confidence and also a high risk of bias.2023info:eu-repo/semantics/articlehttps://portalcientifico.sergas.gal//documentos/64860188a219857f1d78b6e9http://hdl.handle.net/20.500.11940/21278reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/212782026-06-12T08:40:47Z
dc.title.none.fl_str_mv Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis
title Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis
spellingShingle Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis
Silva, F.F.V.E.
Humans
Biomarkers, Tumor
Prognosis
Head and Neck Neoplasms
AS Santiago
IDIS
AS Pontevedra
AS Pontevedra AP
AS A Coruña
AS Coruña AP
AS Santiago
CHUS
AS Santiago
IDIS
title_short Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis
title_full Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis
title_fullStr Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis
title_full_unstemmed Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis
title_sort Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis
dc.creator.none.fl_str_mv Silva, F.F.V.E.
Caponio, V.C.A.
Camolesi, G.C.V.
Padin Iruegas, Maria Elena
Lorenzo Pouso, Alejandro Ismael
Lima, K.C.
Vieira, S.L.S.
Chamorro Petronacci, Cintia Micaela
Suárez Peñaranda, Jose Manuel
Pérez Sayáns, Mario
author Silva, F.F.V.E.
author_facet Silva, F.F.V.E.
Caponio, V.C.A.
Camolesi, G.C.V.
Padin Iruegas, Maria Elena
Lorenzo Pouso, Alejandro Ismael
Lima, K.C.
Vieira, S.L.S.
Chamorro Petronacci, Cintia Micaela
Suárez Peñaranda, Jose Manuel
Pérez Sayáns, Mario
author_role author
author2 Caponio, V.C.A.
Camolesi, G.C.V.
Padin Iruegas, Maria Elena
Lorenzo Pouso, Alejandro Ismael
Lima, K.C.
Vieira, S.L.S.
Chamorro Petronacci, Cintia Micaela
Suárez Peñaranda, Jose Manuel
Pérez Sayáns, Mario
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Humans
Biomarkers, Tumor
Prognosis
Head and Neck Neoplasms
AS Santiago
IDIS
AS Pontevedra
AS Pontevedra AP
AS A Coruña
AS Coruña AP
AS Santiago
CHUS
AS Santiago
IDIS
topic Humans
Biomarkers, Tumor
Prognosis
Head and Neck Neoplasms
AS Santiago
IDIS
AS Pontevedra
AS Pontevedra AP
AS A Coruña
AS Coruña AP
AS Santiago
CHUS
AS Santiago
IDIS
description Head and neck cancer (HNC) is a growing disease, affecting more than 700.000 cases per year and ranking as the sixth most prevalent type of cancer worldwide. The impossibility of properly entering into apoptosis directly influences uncontrolled growth and consequently tumor development and progression. Bcl-2 emerged as a key regulator in the balance between cell apoptosis and proliferation in apoptosis machinery. This systematic review and meta-analysis aimed to review all published studies investigating changes in Bcl-2 protein expression assessed by immunohistochemistry (IHC) and related to prognostic and survival values of patients with HNC. After applying the inclusion and exclusion factors, we reached the number of 20 articles included in the meta-analysis. The random-effect pooled HR (CI95%) value of OS related to Bcl-2 IHC expression in tissues from HNC patients was 1.80 (CI95% 1.21-2.67) (p 0.0001) and DFS was 1.90 (CI95% 1.26-2.86 (p 0.0001). The OS value for the specific oral cavity tumors was 1.89 (1.34-2.67), while in the larynx it was 1.77 (0.62-5.06), and the DFS in the pharynx was 2.02 (1.46-2.79). The univariate and multivariate analyses of OS were respectively 1.43 (1.11-1.86) and 1.88 (1.12-3.16), while in DFS it was 1.70 (0.95-3.03) and 2.08 (1.55-2.80). The OS considering a low cut-off for Bcl-2 positivity was 1.19 (0.60-2.37) and DFS was 1.48 (0.91-2.41), while studies with a high cut-off demonstrated OS of 2.28 (1.47-3.52) and DFS of 2.77 (1.74-4.40). Our meta-analysis demonstrates that Bcl-2 protein overexpression can result in worse LNM, OS, and DFS in patients with HNC, however, it is not a reliable conclusion, due to the wide divergences between the original studies and the fact that many studies have a very high range of confidence and also a high risk of bias.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://portalcientifico.sergas.gal//documentos/64860188a219857f1d78b6e9
http://hdl.handle.net/20.500.11940/21278
url https://portalcientifico.sergas.gal//documentos/64860188a219857f1d78b6e9
http://hdl.handle.net/20.500.11940/21278
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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