Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review

Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disorder often considered a model of accelerated aging due to the early appearance of certain age-related clinical manifestations and cellular and molecular aging markers. Frailty, a state of vulnerability related to aging, has been recen...

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Autores: Garmendia Zaldua, Joana, Labayru Isusquiza, Garazi, De Souto Barreto, Philipe, Vergara Micheltorena, María Iciar, López de Munain Arregui, Adolfo José, Sistiaga Berrondo, Andone
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/75135
Acceso en línea:http://hdl.handle.net/10810/75135
Access Level:acceso abierto
Palabra clave:Steinert’s disease
Fried’s frailty phenotype
accelerated aging
disease-related frailty
senescence, psychosocial factors
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spelling Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative ReviewGarmendia Zaldua, JoanaLabayru Isusquiza, GaraziDe Souto Barreto, PhilipeVergara Micheltorena, María IciarLópez de Munain Arregui, Adolfo JoséSistiaga Berrondo, AndoneSteinert’s diseaseFried’s frailty phenotypeaccelerated agingdisease-related frailtysenescence, psychosocial factorsMyotonic dystrophy type 1 (DM1) is an inherited neuromuscular disorder often considered a model of accelerated aging due to the early appearance of certain age-related clinical manifestations and cellular and molecular aging markers. Frailty, a state of vulnerability related to aging, has been recently studied in neurological conditions but has received considerably less attention in neuromuscular disorders. This narrative review aims to describe 1) the common characteristics between Fried’s frailty phenotype criteria (muscular weakness, slow gait speed, weight loss, exhaustion/fatigue, and low physical activity) and DM1, and 2) the psychological and social factors potentially contributing to frailty in DM1. This review gathered evidence suggesting that DM1 patients meet four of the five frailty phenotype criteria. Additionally, longitudinal studies report the deterioration of these criteria over time in DM1. Patients also exhibit psychological/cognitive and social factors that might contribute to frailty. Monitoring frailty criteria in the DM1 population could help to implement timely preventions and interventions to reduce the disease burden and severity of frailty symptoms.This work was supported by Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (Ref: 609), from the Institute of Health Carlos III cofounded by the European Union [PI22/01118 to Andone Sistiaga]; Basque Government [2022111031 to Andone Sistiaga; IT1732-22 to Joana Garmendia, Garazi Labayru, Andone Sistiaga and Adolfo López de Munain]; University of the Basque Country [PIF 20/238 to Joana Garmendia].This work was performed in the context of the IHU HealthAge, which was benefited from funding by the Agence Nationale de la Recherche under the France 2030 program [ANR-23-IAHU-0011 to Philipe de Souto Barreto].Aging and Disease Editorial202520252025info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/75135reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://doi.org/10.14336/AD.2024.0950info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/© 2025 Garmendia et al. This is an open access article distributed under the terms of the creative commons attribution license,oai:addi.ehu.eus:10810/751352026-06-18T09:23:17Z
dc.title.none.fl_str_mv Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review
title Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review
spellingShingle Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review
Garmendia Zaldua, Joana
Steinert’s disease
Fried’s frailty phenotype
accelerated aging
disease-related frailty
senescence, psychosocial factors
title_short Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review
title_full Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review
title_fullStr Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review
title_full_unstemmed Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review
title_sort Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review
dc.creator.none.fl_str_mv Garmendia Zaldua, Joana
Labayru Isusquiza, Garazi
De Souto Barreto, Philipe
Vergara Micheltorena, María Iciar
López de Munain Arregui, Adolfo José
Sistiaga Berrondo, Andone
author Garmendia Zaldua, Joana
author_facet Garmendia Zaldua, Joana
Labayru Isusquiza, Garazi
De Souto Barreto, Philipe
Vergara Micheltorena, María Iciar
López de Munain Arregui, Adolfo José
Sistiaga Berrondo, Andone
author_role author
author2 Labayru Isusquiza, Garazi
De Souto Barreto, Philipe
Vergara Micheltorena, María Iciar
López de Munain Arregui, Adolfo José
Sistiaga Berrondo, Andone
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Steinert’s disease
Fried’s frailty phenotype
accelerated aging
disease-related frailty
senescence, psychosocial factors
topic Steinert’s disease
Fried’s frailty phenotype
accelerated aging
disease-related frailty
senescence, psychosocial factors
description Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disorder often considered a model of accelerated aging due to the early appearance of certain age-related clinical manifestations and cellular and molecular aging markers. Frailty, a state of vulnerability related to aging, has been recently studied in neurological conditions but has received considerably less attention in neuromuscular disorders. This narrative review aims to describe 1) the common characteristics between Fried’s frailty phenotype criteria (muscular weakness, slow gait speed, weight loss, exhaustion/fatigue, and low physical activity) and DM1, and 2) the psychological and social factors potentially contributing to frailty in DM1. This review gathered evidence suggesting that DM1 patients meet four of the five frailty phenotype criteria. Additionally, longitudinal studies report the deterioration of these criteria over time in DM1. Patients also exhibit psychological/cognitive and social factors that might contribute to frailty. Monitoring frailty criteria in the DM1 population could help to implement timely preventions and interventions to reduce the disease burden and severity of frailty symptoms.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/75135
url http://hdl.handle.net/10810/75135
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.14336/AD.2024.0950
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Aging and Disease Editorial
publisher.none.fl_str_mv Aging and Disease Editorial
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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