Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17
Research article Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17 Ainara Mira-Iglesias¹, F Xavier López-Labrador 1,2 , Beatriz Guglieri-López¹, Miguel Tortajada-...
| Autores: | , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad Católica de Valencia San Vicente Mártir |
| Repositorio: | RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir |
| Idioma: | inglés |
| OAI Identifier: | oai:riucv.ucv.es:20.500.12466/3269 |
| Acceso en línea: | http://hdl.handle.net/20.500.12466/3269 |
| Access Level: | acceso abierto |
| Palabra clave: | Vaccination Respiratory Viruses Disease (VAHNSI) Patients vaccinated 3201.04 Patología Clínica 32 Ciencias Médicas 2412.10 Vacunas 3205.05 Enfermedades Infecciosas |
| Sumario: | Research article Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17 Ainara Mira-Iglesias¹, F Xavier López-Labrador 1,2 , Beatriz Guglieri-López¹, Miguel Tortajada-Girbés³, Víctor Baselga-Moreno¹, Laura Cano¹, Juan Mollar-Maseres⁴, Mario Carballido-Fernández5,6 , Germán Schwarz-Chavarri⁷, Javier Díez-Domingo¹, Joan Puig- Barberà 1,8 , Valencia Hospital Network for the Study of Influenza and Respiratory Viruses Disease 1 1. Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), Valencia, Spain 2. Consorcio de Investigación Biomédica de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain 3. Hospital Doctor Peset, Valencia, Spain 4. Hospital Universitario y Politécnico La Fe, Valencia, Spain 5. Hospital General Universitario de Castellón, Castellón, Spain 6. Universidad CEU Cardenal Herrera, Castellón, Spain 7. Hospital General de Alicante, Alicante, Spain 8. Centro de Salud Pública de Castellón, Castellón, Spain Correspondence: Joan Puig-Barbera (jpuigb55@gmail.com) Citation style for this article: Mira-Iglesias Ainara, López-Labrador F Xavier, Guglieri-López Beatriz, Tortajada-Girbés Miguel, Baselga-Moreno Víctor, Cano Laura, Mollar-Maseres Juan, Carballido-Fernández Mario, Schwarz-Chavarri Germán, Díez-Domingo Javier, Puig-Barberà Joan, Valencia Hospital Network for the Study of Influenza and Respiratory Viruses Disease. Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17. Euro Surveill. 2018;23(8):pii=17-00318. https://doi.org/10.2807/1560-7917.ES.2018.23.8.17-00318 Article submitted on 07 May 2017 / accepted on 01 Sep 2017 / published on 22 February 2018 Introduction: Seasonal influenza vaccination is widely recommended for people with risk factors, especially for people who are elderly. However, influenza vac- cine effectiveness (IVE) varies year after year because of the variable antigenic composition of the circulat- ing viruses and the vaccine composition. Methods: We summarise the results of IVE and the impact of pre- vious vaccination among subjects 60 years of age and over in a multicentre prospective study in the Valencia Hospital Surveillance Network for the Study of Influenza and Respiratory Viruses Disease (VAHNSI) in Spain. We applied the test-negative design taking laboratory-confirmed influenza as outcome and vacci- nation status as exposure. Information about potential confounders was obtained from clinical registries or directly from patients. Results: Adjusted IVE was 19% (95% confidence interval (CI): −15 to 43). For patients vaccinated in the current season but not in the two pre- vious seasons, effectiveness was 49% (95% CI: −20 to 78) and for patients vaccinated in the current and any of two previous seasons, effectiveness was 29% (95% CI: −3 to 52). For those patients not vaccinated in the current season but vaccinated in any of the two pre- vious seasons, effectiveness was 53% (95% CI: 8 to 76). Conclusions: Our data show a low vaccine effec- tiveness for the 2016/17 influenza season |
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