Therapeutic strategies against cancer cachexia

Cancer cachexia has two main components: anorexia and metabolic alterations. The main changes associated with the development of this multi-organic syndrome are glucose intolerance, fat depletion and muscle protein hypercatabolism. The aim of this paper is to review the more recent therapeutic appro...

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Autores: Argilés Huguet, Josep Ma., López-Soriano, Francisco J., Stemmler, Britta, Busquets Rius, Sílvia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/130333
Acceso en línea:https://hdl.handle.net/2445/130333
Access Level:acceso abierto
Palabra clave:Caquèxia
Terapèutica
Cachexia
Therapeutics
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spelling Therapeutic strategies against cancer cachexiaArgilés Huguet, Josep Ma.López-Soriano, Francisco J.Stemmler, BrittaBusquets Rius, SílviaCaquèxiaTerapèuticaCachexiaTherapeuticsCancer cachexia has two main components: anorexia and metabolic alterations. The main changes associated with the development of this multi-organic syndrome are glucose intolerance, fat depletion and muscle protein hypercatabolism. The aim of this paper is to review the more recent therapeutic approaches designed to counteract the wasting suffered by the cancer patient with cachexia. Among the most promising approaches we can include the use of ghrelin agonists, beta-blockers, beta-adrenergic agonists, androgen receptor agonists and anti-myostatin peptides. The multi-targeted approach seems essential in these treatments, which should include the combination of both nutritional support, drugs and a suitable program of physical exercise, in order to ameliorate both anorexia and the metabolic changes associated with cachexia. In addition, another very important and crucial aspect to be taken into consideration in the design of clinical trials for the treatment of cancer cachexia is to staging cancer patients in relation with the degree of cachexia, in order to start as early as possible this triple approach in the course of the disease, even before the weight loss can be detected.PAGEPress2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/130333Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.4081/ejtm.2019.7960European Journal of Translational Myology, 2019, vol. 29, num. 1, p. 4-13https://doi.org/10.4081/ejtm.2019.7960cc-by-nc (c) Argilés Huguet, Josep Ma. et al., 2019http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1303332026-05-27T06:46:51Z
dc.title.none.fl_str_mv Therapeutic strategies against cancer cachexia
title Therapeutic strategies against cancer cachexia
spellingShingle Therapeutic strategies against cancer cachexia
Argilés Huguet, Josep Ma.
Caquèxia
Terapèutica
Cachexia
Therapeutics
title_short Therapeutic strategies against cancer cachexia
title_full Therapeutic strategies against cancer cachexia
title_fullStr Therapeutic strategies against cancer cachexia
title_full_unstemmed Therapeutic strategies against cancer cachexia
title_sort Therapeutic strategies against cancer cachexia
dc.creator.none.fl_str_mv Argilés Huguet, Josep Ma.
López-Soriano, Francisco J.
Stemmler, Britta
Busquets Rius, Sílvia
author Argilés Huguet, Josep Ma.
author_facet Argilés Huguet, Josep Ma.
López-Soriano, Francisco J.
Stemmler, Britta
Busquets Rius, Sílvia
author_role author
author2 López-Soriano, Francisco J.
Stemmler, Britta
Busquets Rius, Sílvia
author2_role author
author
author
dc.subject.none.fl_str_mv Caquèxia
Terapèutica
Cachexia
Therapeutics
topic Caquèxia
Terapèutica
Cachexia
Therapeutics
description Cancer cachexia has two main components: anorexia and metabolic alterations. The main changes associated with the development of this multi-organic syndrome are glucose intolerance, fat depletion and muscle protein hypercatabolism. The aim of this paper is to review the more recent therapeutic approaches designed to counteract the wasting suffered by the cancer patient with cachexia. Among the most promising approaches we can include the use of ghrelin agonists, beta-blockers, beta-adrenergic agonists, androgen receptor agonists and anti-myostatin peptides. The multi-targeted approach seems essential in these treatments, which should include the combination of both nutritional support, drugs and a suitable program of physical exercise, in order to ameliorate both anorexia and the metabolic changes associated with cachexia. In addition, another very important and crucial aspect to be taken into consideration in the design of clinical trials for the treatment of cancer cachexia is to staging cancer patients in relation with the degree of cachexia, in order to start as early as possible this triple approach in the course of the disease, even before the weight loss can be detected.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/130333
url https://hdl.handle.net/2445/130333
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.4081/ejtm.2019.7960
European Journal of Translational Myology, 2019, vol. 29, num. 1, p. 4-13
https://doi.org/10.4081/ejtm.2019.7960
dc.rights.none.fl_str_mv cc-by-nc (c) Argilés Huguet, Josep Ma. et al., 2019
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Argilés Huguet, Josep Ma. et al., 2019
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PAGEPress
publisher.none.fl_str_mv PAGEPress
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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