Comparison of Rotterdam and Barcelona Magnetic Resonance Imaging Risk Calculators for Predicting Clinically Significant Prostate Cancer

The Barcelona magnetic resonance imaging (MRI)-based risk calculator (BCN MRI-RC) exhibited, in the analysed population, better behaviour than the Rotterdam-MRI risk calculator to improve candidate selection for prostate biopsy for the early detection of clinically significant prostate cancer. We no...

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Autores: Morote Robles, Juan|||0000-0002-2168-323X, Borque-Fernando, Ángel|||0000-0003-0178-4567, Triquell, Marina|||0000-0003-3881-8177, Campistol i Torres, Miriam|||0000-0002-3212-3473, Servian, Pol|||0000-0002-3727-8159, Abascal, Jose Maria|||0000-0001-8374-6593, Planas Morin, Jacques|||0000-0002-0222-584X, Méndez Fernández, Olga|||0000-0003-4237-330X, Esteban, Luis M.|||0000-0002-3007-302X, Trilla Herrera, Enrique|||0000-0001-9401-0872
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:282340
Acesso em linha:https://ddd.uab.cat/record/282340
https://dx.doi.org/urn:doi:10.1016/j.euros.2023.03.013
Access Level:acceso abierto
Palavra-chave:Clinically significant
Early detection
Magnetic resonance imaging
Predictive model
Prostate cancer
Risk calculator
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spelling Comparison of Rotterdam and Barcelona Magnetic Resonance Imaging Risk Calculators for Predicting Clinically Significant Prostate CancerMorote Robles, Juan|||0000-0002-2168-323XBorque-Fernando, Ángel|||0000-0003-0178-4567Triquell, Marina|||0000-0003-3881-8177Campistol i Torres, Miriam|||0000-0002-3212-3473Servian, Pol|||0000-0002-3727-8159Abascal, Jose Maria|||0000-0001-8374-6593Planas Morin, Jacques|||0000-0002-0222-584XMéndez Fernández, Olga|||0000-0003-4237-330XEsteban, Luis M.|||0000-0002-3007-302XTrilla Herrera, Enrique|||0000-0001-9401-0872Clinically significantEarly detectionMagnetic resonance imagingPredictive modelProstate cancerRisk calculatorThe Barcelona magnetic resonance imaging (MRI)-based risk calculator (BCN MRI-RC) exhibited, in the analysed population, better behaviour than the Rotterdam-MRI risk calculator to improve candidate selection for prostate biopsy for the early detection of clinically significant prostate cancer. We note the importance of the discrimination, net benefit, and clinical utility analysis regarding Prostate Imaging Reporting and Data System (PI-RADS) categories. We summarise that both risk calculators were helpful in men with PI-RADS 3, only the BCN MRI-RC in those with PI-RADS 4, and none of these in men with negative MRI and PI-RADS 5. Magnetic resonance imaging (MRI)-based risk calculators (MRI-RCs) individualise the likelihood of clinically significant prostate cancer (csPCa) and improve candidate selection for prostate biopsy beyond the Prostate Imaging Reporting and Data System (PI-RADS). To compare the Barcelona (BCN) and Rotterdam (ROT) MRI-RCs in an entire population and according to the PI-RADS categories. A prospective comparison of BCN- and ROT-RC in 946 men with suspected prostate cancer in whom systematic biopsy was performed, as well as target biopsies of PI-RADS ≥3 lesions. Saved biopsies and undetected csPCa (grade group ≥2) were determined. The csPCa detection was 40.8%. The median risks of csPCa from BCN- and ROT-RC were, respectively, 67.1% and 25% in men with csPCa, whereas 10.5% and 3% in those without csPCa (p < 0.001). The areas under the curve were 0.856 and 0.844, respectively (p = 0.116). BCN-RC showed a higher net benefit and clinical utility over ROT-RC. Using appropriate thresholds, respectively, 75% and 80% of biopsies were needed to identify 50% of csPCa detected in men with PI-RADS <3, whereas 35% and 21% of biopsies were saved, missing 10% of csPCa detected in men with PI-RADS 3. BCN-RC saved 15% of biopsies, missing 2% of csPCa in men with PI-RADS 4, whereas ROT-RC saved 10%, missing 6%. No RC saved biopsies without missing csPCa in men with PI-RADS 5. ROT-RC provided a lower and narrower range of csPCa probabilities than BCN-RC. BCN-RC showed a net benefit over ROT-RC in the entire population. However, BCN-RC was useful in men with PI-RADS 3 and 4, whereas ROT-RC was useful only in those with PI-RADS 3. No RC seemed to be helpful in men with negative MRI and PI-RADS 5. Barcelona risk calculator was more helpful than Rotterdam risk calculator to select candidates for prostate biopsy.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/282340https://dx.doi.org/urn:doi:10.1016/j.euros.2023.03.013reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/01666open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2823402026-06-06T12:50:31Z
dc.title.none.fl_str_mv Comparison of Rotterdam and Barcelona Magnetic Resonance Imaging Risk Calculators for Predicting Clinically Significant Prostate Cancer
title Comparison of Rotterdam and Barcelona Magnetic Resonance Imaging Risk Calculators for Predicting Clinically Significant Prostate Cancer
spellingShingle Comparison of Rotterdam and Barcelona Magnetic Resonance Imaging Risk Calculators for Predicting Clinically Significant Prostate Cancer
Morote Robles, Juan|||0000-0002-2168-323X
Clinically significant
Early detection
Magnetic resonance imaging
Predictive model
Prostate cancer
Risk calculator
title_short Comparison of Rotterdam and Barcelona Magnetic Resonance Imaging Risk Calculators for Predicting Clinically Significant Prostate Cancer
title_full Comparison of Rotterdam and Barcelona Magnetic Resonance Imaging Risk Calculators for Predicting Clinically Significant Prostate Cancer
title_fullStr Comparison of Rotterdam and Barcelona Magnetic Resonance Imaging Risk Calculators for Predicting Clinically Significant Prostate Cancer
title_full_unstemmed Comparison of Rotterdam and Barcelona Magnetic Resonance Imaging Risk Calculators for Predicting Clinically Significant Prostate Cancer
title_sort Comparison of Rotterdam and Barcelona Magnetic Resonance Imaging Risk Calculators for Predicting Clinically Significant Prostate Cancer
dc.creator.none.fl_str_mv Morote Robles, Juan|||0000-0002-2168-323X
Borque-Fernando, Ángel|||0000-0003-0178-4567
Triquell, Marina|||0000-0003-3881-8177
Campistol i Torres, Miriam|||0000-0002-3212-3473
Servian, Pol|||0000-0002-3727-8159
Abascal, Jose Maria|||0000-0001-8374-6593
Planas Morin, Jacques|||0000-0002-0222-584X
Méndez Fernández, Olga|||0000-0003-4237-330X
Esteban, Luis M.|||0000-0002-3007-302X
Trilla Herrera, Enrique|||0000-0001-9401-0872
author Morote Robles, Juan|||0000-0002-2168-323X
author_facet Morote Robles, Juan|||0000-0002-2168-323X
Borque-Fernando, Ángel|||0000-0003-0178-4567
Triquell, Marina|||0000-0003-3881-8177
Campistol i Torres, Miriam|||0000-0002-3212-3473
Servian, Pol|||0000-0002-3727-8159
Abascal, Jose Maria|||0000-0001-8374-6593
Planas Morin, Jacques|||0000-0002-0222-584X
Méndez Fernández, Olga|||0000-0003-4237-330X
Esteban, Luis M.|||0000-0002-3007-302X
Trilla Herrera, Enrique|||0000-0001-9401-0872
author_role author
author2 Borque-Fernando, Ángel|||0000-0003-0178-4567
Triquell, Marina|||0000-0003-3881-8177
Campistol i Torres, Miriam|||0000-0002-3212-3473
Servian, Pol|||0000-0002-3727-8159
Abascal, Jose Maria|||0000-0001-8374-6593
Planas Morin, Jacques|||0000-0002-0222-584X
Méndez Fernández, Olga|||0000-0003-4237-330X
Esteban, Luis M.|||0000-0002-3007-302X
Trilla Herrera, Enrique|||0000-0001-9401-0872
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Clinically significant
Early detection
Magnetic resonance imaging
Predictive model
Prostate cancer
Risk calculator
topic Clinically significant
Early detection
Magnetic resonance imaging
Predictive model
Prostate cancer
Risk calculator
description The Barcelona magnetic resonance imaging (MRI)-based risk calculator (BCN MRI-RC) exhibited, in the analysed population, better behaviour than the Rotterdam-MRI risk calculator to improve candidate selection for prostate biopsy for the early detection of clinically significant prostate cancer. We note the importance of the discrimination, net benefit, and clinical utility analysis regarding Prostate Imaging Reporting and Data System (PI-RADS) categories. We summarise that both risk calculators were helpful in men with PI-RADS 3, only the BCN MRI-RC in those with PI-RADS 4, and none of these in men with negative MRI and PI-RADS 5. Magnetic resonance imaging (MRI)-based risk calculators (MRI-RCs) individualise the likelihood of clinically significant prostate cancer (csPCa) and improve candidate selection for prostate biopsy beyond the Prostate Imaging Reporting and Data System (PI-RADS). To compare the Barcelona (BCN) and Rotterdam (ROT) MRI-RCs in an entire population and according to the PI-RADS categories. A prospective comparison of BCN- and ROT-RC in 946 men with suspected prostate cancer in whom systematic biopsy was performed, as well as target biopsies of PI-RADS ≥3 lesions. Saved biopsies and undetected csPCa (grade group ≥2) were determined. The csPCa detection was 40.8%. The median risks of csPCa from BCN- and ROT-RC were, respectively, 67.1% and 25% in men with csPCa, whereas 10.5% and 3% in those without csPCa (p < 0.001). The areas under the curve were 0.856 and 0.844, respectively (p = 0.116). BCN-RC showed a higher net benefit and clinical utility over ROT-RC. Using appropriate thresholds, respectively, 75% and 80% of biopsies were needed to identify 50% of csPCa detected in men with PI-RADS <3, whereas 35% and 21% of biopsies were saved, missing 10% of csPCa detected in men with PI-RADS 3. BCN-RC saved 15% of biopsies, missing 2% of csPCa in men with PI-RADS 4, whereas ROT-RC saved 10%, missing 6%. No RC saved biopsies without missing csPCa in men with PI-RADS 5. ROT-RC provided a lower and narrower range of csPCa probabilities than BCN-RC. BCN-RC showed a net benefit over ROT-RC in the entire population. However, BCN-RC was useful in men with PI-RADS 3 and 4, whereas ROT-RC was useful only in those with PI-RADS 3. No RC seemed to be helpful in men with negative MRI and PI-RADS 5. Barcelona risk calculator was more helpful than Rotterdam risk calculator to select candidates for prostate biopsy.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/282340
https://dx.doi.org/urn:doi:10.1016/j.euros.2023.03.013
url https://ddd.uab.cat/record/282340
https://dx.doi.org/urn:doi:10.1016/j.euros.2023.03.013
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/01666
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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