Early stages of diffuse idiopathic skeletal hyperostosis (DISH) and chronic infammation: the Camargo Cohort Study

Introduction/objectives: DISH has traditionally been considered a non-inflammatory rheumatic disorder. Currently, an inflammatory component has been theorized in the early phases of this condition (EDISH). The study is aimed at investigating a possible relationship between EDISH and chronic inflamma...

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Autores: Pariente Rodrigo, Emilio Jesús|||0000-0003-0035-3298, Pini, Stefanie F., Olmos Martínez, José Manuel, Fierro, Patricia, Landeras, Rosa, Ramos Barrón, María del Carmen, Martínez Taboada, Víctor Manuel, Hernández Hernández, José Luis
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/31738
Acceso en línea:https://hdl.handle.net/10902/31738
Access Level:acceso abierto
Palabra clave:Chronic infammation
C-reactive protein
Difuse idiopathic skeletal hyperostosis
Infammatory markers
Trabecular bone score
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spelling Early stages of diffuse idiopathic skeletal hyperostosis (DISH) and chronic infammation: the Camargo Cohort StudyPariente Rodrigo, Emilio Jesús|||0000-0003-0035-3298Pini, Stefanie F.Olmos Martínez, José ManuelFierro, PatriciaLanderas, RosaRamos Barrón, María del CarmenMartínez Taboada, Víctor ManuelHernández Hernández, José LuisChronic infammationC-reactive proteinDifuse idiopathic skeletal hyperostosisInfammatory markersTrabecular bone scoreIntroduction/objectives: DISH has traditionally been considered a non-inflammatory rheumatic disorder. Currently, an inflammatory component has been theorized in the early phases of this condition (EDISH). The study is aimed at investigating a possible relationship between EDISH and chronic inflammation. Method: Analytical-observational study: participants from the Camargo Cohort Study were enrolled. We collected clinical, radiological, and laboratory data. C-reactive protein (CRP), albumin-to-globulin ratio (AGR), and triglyceride-glucose (TyG) index were assessed. EDISH was defined by Schlapbach's scale grades I or II. A fuzzy matching with tolerance factor = 0.2 was performed. Subjects without ossification (NDISH), sex- and age-matched with cases (1:4), acted as controls. Definite DISH was an exclusion criterion. Multivariable analyses were performed. Results: We evaluated 987 persons (mean age 64 ± 8 years; 191 cases with 63.9% women). EDISH subjects presented more frequently obesity, T2DM, MetS, and the lipid pattern [↑TG ↓TC]. TyG index and alkaline phosphatase (ALP) were higher. Trabecular bone score (TBS) was significantly lower (1.310 [0.2] vs. 1.342 [0.1]; =0.025). CRP and ALP showed the highest correlation (r=0.510; p=0.0001) at lowest TBS level. AGR was lower, and its correlations with ALP (r=-0.219; p=0.0001) and CTX (r=- 0.153; p= 0.022), were weaker or non-significant in NDISH. After adjustment for potential confounders, estimated CRP means for EDISH and NDISH were 0.52 (95% CI: 0.43-0.62) and 0.41 (95% CI: 0.36-0.46), respectively (p=0.038). Conclusions: EDISH was associated with chronic inflammation. Findings revealed an interplay between inflammation, trabecular impairment, and the onset of ossification. Lipid alterations were similar to those observed in chronic-inflammatory diseasesThis work was supported by a grant from Instituto de Salud Carlos III (PI21/00532) that could be co-funded by European Union FEDER funds.SpringerUniversidad de Cantabria20232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/31738Clinical Rheumatology, 2023, 42(7), 1931-1941reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/317382026-06-02T12:39:31Z
dc.title.none.fl_str_mv Early stages of diffuse idiopathic skeletal hyperostosis (DISH) and chronic infammation: the Camargo Cohort Study
title Early stages of diffuse idiopathic skeletal hyperostosis (DISH) and chronic infammation: the Camargo Cohort Study
spellingShingle Early stages of diffuse idiopathic skeletal hyperostosis (DISH) and chronic infammation: the Camargo Cohort Study
Pariente Rodrigo, Emilio Jesús|||0000-0003-0035-3298
Chronic infammation
C-reactive protein
Difuse idiopathic skeletal hyperostosis
Infammatory markers
Trabecular bone score
title_short Early stages of diffuse idiopathic skeletal hyperostosis (DISH) and chronic infammation: the Camargo Cohort Study
title_full Early stages of diffuse idiopathic skeletal hyperostosis (DISH) and chronic infammation: the Camargo Cohort Study
title_fullStr Early stages of diffuse idiopathic skeletal hyperostosis (DISH) and chronic infammation: the Camargo Cohort Study
title_full_unstemmed Early stages of diffuse idiopathic skeletal hyperostosis (DISH) and chronic infammation: the Camargo Cohort Study
title_sort Early stages of diffuse idiopathic skeletal hyperostosis (DISH) and chronic infammation: the Camargo Cohort Study
dc.creator.none.fl_str_mv Pariente Rodrigo, Emilio Jesús|||0000-0003-0035-3298
Pini, Stefanie F.
Olmos Martínez, José Manuel
Fierro, Patricia
Landeras, Rosa
Ramos Barrón, María del Carmen
Martínez Taboada, Víctor Manuel
Hernández Hernández, José Luis
author Pariente Rodrigo, Emilio Jesús|||0000-0003-0035-3298
author_facet Pariente Rodrigo, Emilio Jesús|||0000-0003-0035-3298
Pini, Stefanie F.
Olmos Martínez, José Manuel
Fierro, Patricia
Landeras, Rosa
Ramos Barrón, María del Carmen
Martínez Taboada, Víctor Manuel
Hernández Hernández, José Luis
author_role author
author2 Pini, Stefanie F.
Olmos Martínez, José Manuel
Fierro, Patricia
Landeras, Rosa
Ramos Barrón, María del Carmen
Martínez Taboada, Víctor Manuel
Hernández Hernández, José Luis
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Chronic infammation
C-reactive protein
Difuse idiopathic skeletal hyperostosis
Infammatory markers
Trabecular bone score
topic Chronic infammation
C-reactive protein
Difuse idiopathic skeletal hyperostosis
Infammatory markers
Trabecular bone score
description Introduction/objectives: DISH has traditionally been considered a non-inflammatory rheumatic disorder. Currently, an inflammatory component has been theorized in the early phases of this condition (EDISH). The study is aimed at investigating a possible relationship between EDISH and chronic inflammation. Method: Analytical-observational study: participants from the Camargo Cohort Study were enrolled. We collected clinical, radiological, and laboratory data. C-reactive protein (CRP), albumin-to-globulin ratio (AGR), and triglyceride-glucose (TyG) index were assessed. EDISH was defined by Schlapbach's scale grades I or II. A fuzzy matching with tolerance factor = 0.2 was performed. Subjects without ossification (NDISH), sex- and age-matched with cases (1:4), acted as controls. Definite DISH was an exclusion criterion. Multivariable analyses were performed. Results: We evaluated 987 persons (mean age 64 ± 8 years; 191 cases with 63.9% women). EDISH subjects presented more frequently obesity, T2DM, MetS, and the lipid pattern [↑TG ↓TC]. TyG index and alkaline phosphatase (ALP) were higher. Trabecular bone score (TBS) was significantly lower (1.310 [0.2] vs. 1.342 [0.1]; =0.025). CRP and ALP showed the highest correlation (r=0.510; p=0.0001) at lowest TBS level. AGR was lower, and its correlations with ALP (r=-0.219; p=0.0001) and CTX (r=- 0.153; p= 0.022), were weaker or non-significant in NDISH. After adjustment for potential confounders, estimated CRP means for EDISH and NDISH were 0.52 (95% CI: 0.43-0.62) and 0.41 (95% CI: 0.36-0.46), respectively (p=0.038). Conclusions: EDISH was associated with chronic inflammation. Findings revealed an interplay between inflammation, trabecular impairment, and the onset of ossification. Lipid alterations were similar to those observed in chronic-inflammatory diseases
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/31738
url https://hdl.handle.net/10902/31738
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Clinical Rheumatology, 2023, 42(7), 1931-1941
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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