Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions

13 páginas, 2 figuras

Detalles Bibliográficos
Autores: Cano Argüelles, Ana Laura, Abuin-Denis, Lianet, Obregon, Dasiel, Mateos-Hernandez, Lourdes, Maître, Apolline, Piloto-Sardiñas, Elianne, Wu-Chuang, Alejandra, Tonnerre, Pierre, Cabezas-Cruz, Alejandro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/410144
Acceso en línea:http://hdl.handle.net/10261/410144
https://api.elsevier.com/content/abstract/scopus_id/105010476298
Access Level:acceso abierto
Palabra clave:Jenner/Pasteur paradigm
Pathogen adaptation
Pathogen ecology
Public health strategies
Vaccination
Vector-borne pathogen
vaccination
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spelling Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactionsCano Argüelles, Ana LauraAbuin-Denis, LianetObregon, DasielMateos-Hernandez, LourdesMaître, ApollinePiloto-Sardiñas, ElianneWu-Chuang, AlejandraTonnerre, PierreCabezas-Cruz, AlejandroJenner/Pasteur paradigmPathogen adaptationPathogen ecologyPublic health strategiesVaccinationVector-borne pathogenvaccination13 páginas, 2 figurasVaccination campaigns have profoundly influenced the dynamics of infectious diseases, acting as one of the largest ecological experiments in history. By vaccinating billions across decades, we have imposed powerful selective pressures on pathogens, illuminating their ability to adapt, evade, or persist. Rooted in the Jenner/Pasteur paradigm - where exposure to an antigen induces protective immunity - vaccines have revealed how pathogens differ in their ecological susceptibility to immunity. Using this framework, pathogens can be categorized based on their strategies to endure, from those limited by direct immunity to those relying on antigenic variation, chronic infection, or reservoirs. Vector-borne pathogens (VBPs) present a set of challenges to vaccination efforts due to their complex life cycles, stage-specific antigen expression, and reliance on arthropod vectors for transmission. These pathogens not only evade host immunity but also adapt to selective pressures within the vector's microbiome and immune system. Such complexity often places VBPs beyond the scope of traditional vaccine paradigms, requiring alternative strategies such as transmission-blocking and vector-targeted vaccines. This review explores these insights, examining the interplay between vaccination, pathogen ecology, and evolution - with special emphasis on VBPs - to guide future strategies in vector-borne disease (VBD) control.Alejandro Cabezas-Cruz is supported by the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence “Integrative Biology of Emerging Infectious Diseases” (grant no. ANR-10-LABX-62-IBEID). Pierre Tonnerre is supported by the ATIP-Avenir program from INSERM and CNRS. Ana Laura Cano-Argüelles is hired under the Generation D initiative, promoted by Red.es, an organisation attached to the Ministry for Digital Transformation and the Civil Service, for the attraction and retention of talent through grants and training contracts, financed by the Recovery, Transformation and Resilience Plan through the European Union’s Next Generation fundsPeer reviewedElsevierCano Argüelles, Ana Laura [0000-0002-1056-8439]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/410144https://api.elsevier.com/content/abstract/scopus_id/105010476298reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.crpvbd.2025.100291Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4101442026-05-22T06:33:51Z
dc.title.none.fl_str_mv Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions
title Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions
spellingShingle Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions
Cano Argüelles, Ana Laura
Jenner/Pasteur paradigm
Pathogen adaptation
Pathogen ecology
Public health strategies
Vaccination
Vector-borne pathogen
vaccination
title_short Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions
title_full Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions
title_fullStr Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions
title_full_unstemmed Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions
title_sort Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions
dc.creator.none.fl_str_mv Cano Argüelles, Ana Laura
Abuin-Denis, Lianet
Obregon, Dasiel
Mateos-Hernandez, Lourdes
Maître, Apolline
Piloto-Sardiñas, Elianne
Wu-Chuang, Alejandra
Tonnerre, Pierre
Cabezas-Cruz, Alejandro
author Cano Argüelles, Ana Laura
author_facet Cano Argüelles, Ana Laura
Abuin-Denis, Lianet
Obregon, Dasiel
Mateos-Hernandez, Lourdes
Maître, Apolline
Piloto-Sardiñas, Elianne
Wu-Chuang, Alejandra
Tonnerre, Pierre
Cabezas-Cruz, Alejandro
author_role author
author2 Abuin-Denis, Lianet
Obregon, Dasiel
Mateos-Hernandez, Lourdes
Maître, Apolline
Piloto-Sardiñas, Elianne
Wu-Chuang, Alejandra
Tonnerre, Pierre
Cabezas-Cruz, Alejandro
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Cano Argüelles, Ana Laura [0000-0002-1056-8439]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Jenner/Pasteur paradigm
Pathogen adaptation
Pathogen ecology
Public health strategies
Vaccination
Vector-borne pathogen
vaccination
topic Jenner/Pasteur paradigm
Pathogen adaptation
Pathogen ecology
Public health strategies
Vaccination
Vector-borne pathogen
vaccination
description 13 páginas, 2 figuras
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/410144
https://api.elsevier.com/content/abstract/scopus_id/105010476298
url http://hdl.handle.net/10261/410144
https://api.elsevier.com/content/abstract/scopus_id/105010476298
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.crpvbd.2025.100291
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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