Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study

Purpose: Vitamin D deficiency has been associated with multiple chronic diseases, including metabolic disorders such as insulin resistance and type 2 diabetes (T2D). The aim of the study was to analyze the association between validated predicted serum vitamin D status and the risk of developing T2D...

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Autores: Valer-Martínez, Ana, Sayón-Orea, Carmen, Martínez, José Alfredo, Basterra Gortari, Francisco Javier, Martínez González, Miguel Ángel, Bes-Rastrollo, Maira
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/51603
Acceso en línea:https://hdl.handle.net/2454/51603
Access Level:acceso abierto
Palabra clave:Predicted vitamin D
Prospective cohort
SUN project
Type 2 diabetes
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spelling Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort studyValer-Martínez, AnaSayón-Orea, CarmenMartínez, José AlfredoBasterra Gortari, Francisco JavierMartínez González, Miguel ÁngelBes-Rastrollo, MairaPredicted vitamin DProspective cohortSUN projectType 2 diabetesPurpose: Vitamin D deficiency has been associated with multiple chronic diseases, including metabolic disorders such as insulin resistance and type 2 diabetes (T2D). The aim of the study was to analyze the association between validated predicted serum vitamin D status and the risk of developing T2D in a large prospective cohort based on a Mediterranean population. Methods: The SUN project is a prospective and dynamic Spanish cohort that gathers university graduates who have answered lifestyle questionnaires, including a validated Food Frequency Questionnaire. The association between predicted serum vitamin D and the risk of T2D was assessed through Cox regression models according to quartiles (Q) of predicted vitamin D at baseline. The models were adjusted for potential confounders and sensitivity analyses were performed to ensure the robustness of our findings. Results: Our study included a total of 18,594 participants and after a total follow-up of 238,078 person-years (median follow-up of 13.5 years), 209 individuals were diagnosed with incident T2D. We found a significant inverse association between predicted levels of serum vitamin D and the risk of developing T2D, after adjusting for potential confounders and performing different sensitivity analyses (hazard ratio Q4 vs. Q1: 0.48, 95% CI 0.26¿0.88; p for trend = 0.032). Conclusion: The outcomes suggest that higher levels of vitamin D at baseline may be associated with a reduced risk of developing T2D.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. The SUN project has received funding from the Spanish Government-Instituto de Salud Carlos III, the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI20/00564, PI23/01332, and G03/140), the Navarra Regional Government (27/2011, 45/2011, 122/2014), the National Plan on Drugs (2020/021), and the University of Navarra.SpringerCiencias de la SaludOsasun Zientziak2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/51603reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement///PI10%2F02658info:eu-repo/grantAgreement///PI10%2F02293info:eu-repo/grantAgreement/MINECO//PI13%2F00615info:eu-repo/grantAgreement/MINECO//PI14%2F01668info:eu-repo/grantAgreement/MINECO//PI14%2F01798info:eu-repo/grantAgreement/MINECO//PI14%2F01764info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01795info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00564info:eu-repo/grantAgreement///PI23%2F01332info:eu-repo/grantAgreement///G03%2F140info:eu-repo/grantAgreement/Gobierno de Navarra//27%2F2011info:eu-repo/grantAgreement/Gobierno de Navarra//45%2F2011info:eu-repo/grantAgreement/Gobierno de Navarra//122%2F2014© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/516032026-06-17T12:41:47Z
dc.title.none.fl_str_mv Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study
title Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study
spellingShingle Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study
Valer-Martínez, Ana
Predicted vitamin D
Prospective cohort
SUN project
Type 2 diabetes
title_short Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study
title_full Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study
title_fullStr Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study
title_full_unstemmed Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study
title_sort Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study
dc.creator.none.fl_str_mv Valer-Martínez, Ana
Sayón-Orea, Carmen
Martínez, José Alfredo
Basterra Gortari, Francisco Javier
Martínez González, Miguel Ángel
Bes-Rastrollo, Maira
author Valer-Martínez, Ana
author_facet Valer-Martínez, Ana
Sayón-Orea, Carmen
Martínez, José Alfredo
Basterra Gortari, Francisco Javier
Martínez González, Miguel Ángel
Bes-Rastrollo, Maira
author_role author
author2 Sayón-Orea, Carmen
Martínez, José Alfredo
Basterra Gortari, Francisco Javier
Martínez González, Miguel Ángel
Bes-Rastrollo, Maira
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
dc.subject.none.fl_str_mv Predicted vitamin D
Prospective cohort
SUN project
Type 2 diabetes
topic Predicted vitamin D
Prospective cohort
SUN project
Type 2 diabetes
description Purpose: Vitamin D deficiency has been associated with multiple chronic diseases, including metabolic disorders such as insulin resistance and type 2 diabetes (T2D). The aim of the study was to analyze the association between validated predicted serum vitamin D status and the risk of developing T2D in a large prospective cohort based on a Mediterranean population. Methods: The SUN project is a prospective and dynamic Spanish cohort that gathers university graduates who have answered lifestyle questionnaires, including a validated Food Frequency Questionnaire. The association between predicted serum vitamin D and the risk of T2D was assessed through Cox regression models according to quartiles (Q) of predicted vitamin D at baseline. The models were adjusted for potential confounders and sensitivity analyses were performed to ensure the robustness of our findings. Results: Our study included a total of 18,594 participants and after a total follow-up of 238,078 person-years (median follow-up of 13.5 years), 209 individuals were diagnosed with incident T2D. We found a significant inverse association between predicted levels of serum vitamin D and the risk of developing T2D, after adjusting for potential confounders and performing different sensitivity analyses (hazard ratio Q4 vs. Q1: 0.48, 95% CI 0.26¿0.88; p for trend = 0.032). Conclusion: The outcomes suggest that higher levels of vitamin D at baseline may be associated with a reduced risk of developing T2D.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/51603
url https://hdl.handle.net/2454/51603
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement///PI10%2F02658
info:eu-repo/grantAgreement///PI10%2F02293
info:eu-repo/grantAgreement/MINECO//PI13%2F00615
info:eu-repo/grantAgreement/MINECO//PI14%2F01668
info:eu-repo/grantAgreement/MINECO//PI14%2F01798
info:eu-repo/grantAgreement/MINECO//PI14%2F01764
info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01795
info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00564
info:eu-repo/grantAgreement///PI23%2F01332
info:eu-repo/grantAgreement///G03%2F140
info:eu-repo/grantAgreement/Gobierno de Navarra//27%2F2011
info:eu-repo/grantAgreement/Gobierno de Navarra//45%2F2011
info:eu-repo/grantAgreement/Gobierno de Navarra//122%2F2014
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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