Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011–2018

This study explores the relationship between influenza infection, both clinically diagnosed in primary care and laboratory confirmed in hospital, and atherothrombotic events (acute myocardial infarction and ischemic stroke) in Spain. A population-based self- controlled case series design was used wi...

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Authors: Múñoz Quiles, Cintia, López Lacort, Mónica, Urchueguía, Arantxa, Díez Domingo, Javier, Orrico Sánchez, Alejandro
Format: article
Publication Date:2024
Country:España
Institution:Universidad Católica de Valencia San Vicente Mártir
Repository:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Language:English
OAI Identifier:oai:riucv.ucv.es:20.500.12466/4399
Online Access:http://hdl.handle.net/20.500.12466/4399
Access Level:Open access
Keyword:Influenza
Myocardial infarction
Ischemic stroke
Laboratory-confirmed influenza
Clinically diagnosed influenza
3207.04 Patología Cardiovascular
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spelling Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011–2018Múñoz Quiles, CintiaLópez Lacort, MónicaUrchueguía, ArantxaDíez Domingo, JavierOrrico Sánchez, AlejandroInfluenzaMyocardial infarctionIschemic strokeLaboratory-confirmed influenzaClinically diagnosed influenza3207.04 Patología CardiovascularThis study explores the relationship between influenza infection, both clinically diagnosed in primary care and laboratory confirmed in hospital, and atherothrombotic events (acute myocardial infarction and ischemic stroke) in Spain. A population-based self- controlled case series design was used with individual-level data from electronic registries (n = 2 230 015). The risk of atherothrombotic events in subjects ≥50 years old increased more than 2-fold during the 14 days after the mildest influenza cases in patients with fewer risk factors and more than 4-fold after severe cases in the most vulnerable patients, remaining in them more than 2-fold for 2 months. The transient increase of the association, its gradient after influenza infection, and the demonstration by 4 different sensitivity analyses provide further evidence supporting causality. This work reinforces the official recommendations for influenza prevention in at-risk groups and should also increase the awareness of even milder influenza infection and its possible complications in the general population.20242024-06-2520242024-02-0820242024-02-08journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12466/4399reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártirinstname:Universidad Católica de Valencia San Vicente MártirInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riucv.ucv.es:20.500.12466/43992026-06-19T08:32:07Z
dc.title.none.fl_str_mv Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011–2018
title Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011–2018
spellingShingle Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011–2018
Múñoz Quiles, Cintia
Influenza
Myocardial infarction
Ischemic stroke
Laboratory-confirmed influenza
Clinically diagnosed influenza
3207.04 Patología Cardiovascular
title_short Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011–2018
title_full Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011–2018
title_fullStr Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011–2018
title_full_unstemmed Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011–2018
title_sort Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011–2018
dc.creator.none.fl_str_mv Múñoz Quiles, Cintia
López Lacort, Mónica
Urchueguía, Arantxa
Díez Domingo, Javier
Orrico Sánchez, Alejandro
author Múñoz Quiles, Cintia
author_facet Múñoz Quiles, Cintia
López Lacort, Mónica
Urchueguía, Arantxa
Díez Domingo, Javier
Orrico Sánchez, Alejandro
author_role author
author2 López Lacort, Mónica
Urchueguía, Arantxa
Díez Domingo, Javier
Orrico Sánchez, Alejandro
author2_role author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Influenza
Myocardial infarction
Ischemic stroke
Laboratory-confirmed influenza
Clinically diagnosed influenza
3207.04 Patología Cardiovascular
topic Influenza
Myocardial infarction
Ischemic stroke
Laboratory-confirmed influenza
Clinically diagnosed influenza
3207.04 Patología Cardiovascular
description This study explores the relationship between influenza infection, both clinically diagnosed in primary care and laboratory confirmed in hospital, and atherothrombotic events (acute myocardial infarction and ischemic stroke) in Spain. A population-based self- controlled case series design was used with individual-level data from electronic registries (n = 2 230 015). The risk of atherothrombotic events in subjects ≥50 years old increased more than 2-fold during the 14 days after the mildest influenza cases in patients with fewer risk factors and more than 4-fold after severe cases in the most vulnerable patients, remaining in them more than 2-fold for 2 months. The transient increase of the association, its gradient after influenza infection, and the demonstration by 4 different sensitivity analyses provide further evidence supporting causality. This work reinforces the official recommendations for influenza prevention in at-risk groups and should also increase the awareness of even milder influenza infection and its possible complications in the general population.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-06-25
2024
2024-02-08
2024
2024-02-08
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12466/4399
url http://hdl.handle.net/20.500.12466/4399
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
instname:Universidad Católica de Valencia San Vicente Mártir
instname_str Universidad Católica de Valencia San Vicente Mártir
reponame_str RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
collection RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
repository.name.fl_str_mv
repository.mail.fl_str_mv
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