Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology.

Discovered and described 40 years ago, non-specific lipid transfer proteins (nsLTP) are present in many plant species and play an important role protecting plants from stressors such as heat or drought. In the last 20 years, sensitization to nsLTP and consequent reactions to plant foods has become a...

Descripción completa

Detalles Bibliográficos
Autores: Skypala, Isabel J, Asero, Ricardo, Cecchi, Lorenzo, Diaz Perales, Arazeli, Hoffmann-Sommergruber, Karin, Pastorello, Elide A, Swoboda, Ines, Bartra, Joan, Ebo, Didier G, Faber, Margaretha A, Fernández-Rivas, Montserrat, Gomez, Francesca, Konstantinopoulos, Anastasios P, Luengo, Olga, van Ree, Ronald, Scala, Enrico, Till, Stephen J, European Academy of Allergy, Clinical Immunology (EAACI) Task Force: Non‐specific Lipid Transfer Protein Allergy Across Europe
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18348
Acceso en línea:http://hdl.handle.net/20.500.12105/18348
Access Level:acceso abierto
Palabra clave:LTP
allergy
epidemiology
food
lipid transfer protein
sensitization
id ES_2c79d5225c93a8918dcdab8dff3be7ff
oai_identifier_str oai:repisalud.isciii.es:20.500.12105/18348
network_acronym_str ES
network_name_str España
repository_id_str
spelling Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology.Skypala, Isabel JAsero, RicardoCecchi, LorenzoDiaz Perales, ArazeliHoffmann-Sommergruber, KarinPastorello, Elide ASwoboda, InesBartra, JoanEbo, Didier GFaber, Margaretha AFernández-Rivas, MontserratGomez, FrancescaKonstantinopoulos, Anastasios PLuengo, Olgavan Ree, RonaldScala, EnricoTill, Stephen JEuropean Academy of AllergyClinical Immunology (EAACI) Task Force: Non‐specific Lipid Transfer Protein Allergy Across EuropeLTPallergyepidemiologyfoodlipid transfer proteinsensitizationDiscovered and described 40 years ago, non-specific lipid transfer proteins (nsLTP) are present in many plant species and play an important role protecting plants from stressors such as heat or drought. In the last 20 years, sensitization to nsLTP and consequent reactions to plant foods has become an increasing concern. The aim of this paper is to review the evidence for the structure and function of nsLTP allergens, and cross-reactivity, sensitization, and epidemiology of nsLTP allergy. A Task Force, supported by the European Academy of Allergy & Clinical Immunology (EAACI), reviewed current evidence and provide a signpost for future research. The search terms for this paper were "Non-specific Lipid Transfer Proteins", "LTP syndrome", "Pru p 3", "plant food allergy", "pollen-food syndrome". Most nsLTP allergens have a highly conserved structure stabilised by 4-disulphide bridges. Studies on the peach nsLTP, Pru p 3, demonstrate that nsLTPs are very cross-reactive, with the four major IgE epitopes of Pru p 3 being shared by nsLTP from other botanically related fruits. These nsLTP allergens are to varying degrees resistant to heat and digestion, and sensitization may occur through the oral, inhaled or cutaneous routes. In some populations, Pru p 3 is the primary and sole sensitizing allergen, but many are poly-sensitised both to botanically un-related nsLTP in foods, and non-food sources of nsLTP such as Cannabis sativa, Platanus acerifolia, (plane tree), Ambrosia artemisiifolia (ragweed) and Artemisia vulgaris (mugwort). Initially, nsLTP sensitization appeared to be limited to Mediterranean countries, however more recent studies suggest clinically relevant sensitization occurs in North Atlantic regions and also countries in Northern Europe, with nsLTP sensitisation profiles being broadly similar. These robust allergens have the potential to sensitize and provoke symptoms to a large number of plant foods, including those which are raw, cooked or processed. It is unknown why some sensitized individuals develop clinical symptoms to foods whereas others do not, or indeed what other allergens besides Pru p 3 may be primary sensitising allergens. It is clear that these allergens are also relevant in non-Mediterranean populations and there needs to be more recognition of this. Non-specific LTP allergens, present in a wide variety of plant foods and pollens, are structurally robust and so may be present in both raw and cooked foods. More studies are needed to understand routes of sensitization and the world-wide prevalence of clinical symptoms associated with sensitization to these complex allergens.20242024-02-1920212021-05-1820212021-05-18research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/18348reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/183482026-06-12T12:43:37Z
dc.title.none.fl_str_mv Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology.
title Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology.
spellingShingle Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology.
Skypala, Isabel J
LTP
allergy
epidemiology
food
lipid transfer protein
sensitization
title_short Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology.
title_full Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology.
title_fullStr Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology.
title_full_unstemmed Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology.
title_sort Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology.
dc.creator.none.fl_str_mv Skypala, Isabel J
Asero, Ricardo
Cecchi, Lorenzo
Diaz Perales, Arazeli
Hoffmann-Sommergruber, Karin
Pastorello, Elide A
Swoboda, Ines
Bartra, Joan
Ebo, Didier G
Faber, Margaretha A
Fernández-Rivas, Montserrat
Gomez, Francesca
Konstantinopoulos, Anastasios P
Luengo, Olga
van Ree, Ronald
Scala, Enrico
Till, Stephen J
European Academy of Allergy
Clinical Immunology (EAACI) Task Force: Non‐specific Lipid Transfer Protein Allergy Across Europe
author Skypala, Isabel J
author_facet Skypala, Isabel J
Asero, Ricardo
Cecchi, Lorenzo
Diaz Perales, Arazeli
Hoffmann-Sommergruber, Karin
Pastorello, Elide A
Swoboda, Ines
Bartra, Joan
Ebo, Didier G
Faber, Margaretha A
Fernández-Rivas, Montserrat
Gomez, Francesca
Konstantinopoulos, Anastasios P
Luengo, Olga
van Ree, Ronald
Scala, Enrico
Till, Stephen J
European Academy of Allergy
Clinical Immunology (EAACI) Task Force: Non‐specific Lipid Transfer Protein Allergy Across Europe
author_role author
author2 Asero, Ricardo
Cecchi, Lorenzo
Diaz Perales, Arazeli
Hoffmann-Sommergruber, Karin
Pastorello, Elide A
Swoboda, Ines
Bartra, Joan
Ebo, Didier G
Faber, Margaretha A
Fernández-Rivas, Montserrat
Gomez, Francesca
Konstantinopoulos, Anastasios P
Luengo, Olga
van Ree, Ronald
Scala, Enrico
Till, Stephen J
European Academy of Allergy
Clinical Immunology (EAACI) Task Force: Non‐specific Lipid Transfer Protein Allergy Across Europe
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv LTP
allergy
epidemiology
food
lipid transfer protein
sensitization
topic LTP
allergy
epidemiology
food
lipid transfer protein
sensitization
description Discovered and described 40 years ago, non-specific lipid transfer proteins (nsLTP) are present in many plant species and play an important role protecting plants from stressors such as heat or drought. In the last 20 years, sensitization to nsLTP and consequent reactions to plant foods has become an increasing concern. The aim of this paper is to review the evidence for the structure and function of nsLTP allergens, and cross-reactivity, sensitization, and epidemiology of nsLTP allergy. A Task Force, supported by the European Academy of Allergy & Clinical Immunology (EAACI), reviewed current evidence and provide a signpost for future research. The search terms for this paper were "Non-specific Lipid Transfer Proteins", "LTP syndrome", "Pru p 3", "plant food allergy", "pollen-food syndrome". Most nsLTP allergens have a highly conserved structure stabilised by 4-disulphide bridges. Studies on the peach nsLTP, Pru p 3, demonstrate that nsLTPs are very cross-reactive, with the four major IgE epitopes of Pru p 3 being shared by nsLTP from other botanically related fruits. These nsLTP allergens are to varying degrees resistant to heat and digestion, and sensitization may occur through the oral, inhaled or cutaneous routes. In some populations, Pru p 3 is the primary and sole sensitizing allergen, but many are poly-sensitised both to botanically un-related nsLTP in foods, and non-food sources of nsLTP such as Cannabis sativa, Platanus acerifolia, (plane tree), Ambrosia artemisiifolia (ragweed) and Artemisia vulgaris (mugwort). Initially, nsLTP sensitization appeared to be limited to Mediterranean countries, however more recent studies suggest clinically relevant sensitization occurs in North Atlantic regions and also countries in Northern Europe, with nsLTP sensitisation profiles being broadly similar. These robust allergens have the potential to sensitize and provoke symptoms to a large number of plant foods, including those which are raw, cooked or processed. It is unknown why some sensitized individuals develop clinical symptoms to foods whereas others do not, or indeed what other allergens besides Pru p 3 may be primary sensitising allergens. It is clear that these allergens are also relevant in non-Mediterranean populations and there needs to be more recognition of this. Non-specific LTP allergens, present in a wide variety of plant foods and pollens, are structurally robust and so may be present in both raw and cooked foods. More studies are needed to understand routes of sensitization and the world-wide prevalence of clinical symptoms associated with sensitization to these complex allergens.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-05-18
2021
2021-05-18
2024
2024-02-19
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/18348
url http://hdl.handle.net/20.500.12105/18348
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405239430348800
score 15.811543

Similares en LA Referencia