Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic status

Few studies have analyzed the relationship between glucose variability (GV) and adverse health outcomes in patients with differences in glycemic status. The present study tests the hypothesis that GV predicts all-cause mortality regardless of glycemic status after simple adjustment (age and sex) and...

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Autores: Salinero-Fort, Miguel A., Andrés-Rebollo, F. Javier San, Cárdenas-Valladolid, Juan, Mostaza Prieto, José María, Lahoz Rallo, Carlos, Rodríguez Artalejo, Fernando, Gómez-Campelo, Paloma, Vich-Pérez, Pilar, Jiménez-García, Rodrigo, de Andrés, A. L., de Miguel-Yanes, José M.
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/707719
Acceso en línea:http://hdl.handle.net/10486/707719
https://dx.doi.org/10.1371/journal.pone.0271632
Access Level:acceso abierto
Palabra clave:Blood Glucose
Diabetes Mellitus
Glycated Hemoglobin
Cohort Studies
Prediabetic State
Medicina
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spelling Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic statusSalinero-Fort, Miguel A.Andrés-Rebollo, F. Javier SanCárdenas-Valladolid, JuanMostaza Prieto, José MaríaLahoz Rallo, CarlosRodríguez Artalejo, FernandoGómez-Campelo, PalomaVich-Pérez, PilarJiménez-García, Rodrigode Andrés, A. L.de Miguel-Yanes, José M.Blood GlucoseDiabetes MellitusGlycated HemoglobinCohort StudiesPrediabetic StateMedicinaFew studies have analyzed the relationship between glucose variability (GV) and adverse health outcomes in patients with differences in glycemic status. The present study tests the hypothesis that GV predicts all-cause mortality regardless of glycemic status after simple adjustment (age and sex) and full adjustment (age, sex, cardiovascular disease, hypertension, use of aspirin, statins, GLP-1 receptor agonists, SGLT-2 inhibitors and DPP-4 inhibitors, baseline FPG and average HbA1c). Methods Prospective cohort study with 795 normoglycemic patients, 233 patients with prediabetes, and 4,102 patients with type 2 diabetes. GV was measured using the coefficient of variation of fasting plasma glucose (CV-FPG) over 12 years of follow-up. The outcome measure was all-cause mortality. Results A total of 1,223 patients (657 men, 566 women) died after a median of 9.8 years of followup, with an all-cause mortality rate of 23.35/1,000 person-years. In prediabetes or T2DM patients, the fourth quartile of CV-FPG exerted a significant effect on all-cause mortality after simple and full adjustment. A sensitivity analysis excluding participants who died during the first year of follow-up revealed the following results for the highest quartile in the fully adjusted model: overall, HR (95%CI) = 1.54 (1.26–1.89); dysglycemia (prediabetes and T2DM), HR = 1.41 (1.15–1.73); T2DM, HR = 1.36 (1.10–1.67). Conclusion We found CV-FPG to be useful for measurement of GV. It could also be used for the prognostic stratification of patients with dysglycemiaThis study was funded by Instituto de Salud Carlos III through projects “PI15/00259” and “PI18/01025” and co-funded by the European Regional Development Fund,“A way of shaping Europe”. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscriptPublic Library of ScienceDepartamento de MedicinaDepartamento de Medicina Preventiva y Salud Pública y MicrobiologíaFacultad de Medicina20222022-07-25research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/707719https://dx.doi.org/10.1371/journal.pone.0271632reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7077192026-06-23T12:46:27Z
dc.title.none.fl_str_mv Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic status
title Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic status
spellingShingle Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic status
Salinero-Fort, Miguel A.
Blood Glucose
Diabetes Mellitus
Glycated Hemoglobin
Cohort Studies
Prediabetic State
Medicina
title_short Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic status
title_full Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic status
title_fullStr Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic status
title_full_unstemmed Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic status
title_sort Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic status
dc.creator.none.fl_str_mv Salinero-Fort, Miguel A.
Andrés-Rebollo, F. Javier San
Cárdenas-Valladolid, Juan
Mostaza Prieto, José María
Lahoz Rallo, Carlos
Rodríguez Artalejo, Fernando
Gómez-Campelo, Paloma
Vich-Pérez, Pilar
Jiménez-García, Rodrigo
de Andrés, A. L.
de Miguel-Yanes, José M.
author Salinero-Fort, Miguel A.
author_facet Salinero-Fort, Miguel A.
Andrés-Rebollo, F. Javier San
Cárdenas-Valladolid, Juan
Mostaza Prieto, José María
Lahoz Rallo, Carlos
Rodríguez Artalejo, Fernando
Gómez-Campelo, Paloma
Vich-Pérez, Pilar
Jiménez-García, Rodrigo
de Andrés, A. L.
de Miguel-Yanes, José M.
author_role author
author2 Andrés-Rebollo, F. Javier San
Cárdenas-Valladolid, Juan
Mostaza Prieto, José María
Lahoz Rallo, Carlos
Rodríguez Artalejo, Fernando
Gómez-Campelo, Paloma
Vich-Pérez, Pilar
Jiménez-García, Rodrigo
de Andrés, A. L.
de Miguel-Yanes, José M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Departamento de Medicina Preventiva y Salud Pública y Microbiología
Facultad de Medicina
dc.subject.none.fl_str_mv Blood Glucose
Diabetes Mellitus
Glycated Hemoglobin
Cohort Studies
Prediabetic State
Medicina
topic Blood Glucose
Diabetes Mellitus
Glycated Hemoglobin
Cohort Studies
Prediabetic State
Medicina
description Few studies have analyzed the relationship between glucose variability (GV) and adverse health outcomes in patients with differences in glycemic status. The present study tests the hypothesis that GV predicts all-cause mortality regardless of glycemic status after simple adjustment (age and sex) and full adjustment (age, sex, cardiovascular disease, hypertension, use of aspirin, statins, GLP-1 receptor agonists, SGLT-2 inhibitors and DPP-4 inhibitors, baseline FPG and average HbA1c). Methods Prospective cohort study with 795 normoglycemic patients, 233 patients with prediabetes, and 4,102 patients with type 2 diabetes. GV was measured using the coefficient of variation of fasting plasma glucose (CV-FPG) over 12 years of follow-up. The outcome measure was all-cause mortality. Results A total of 1,223 patients (657 men, 566 women) died after a median of 9.8 years of followup, with an all-cause mortality rate of 23.35/1,000 person-years. In prediabetes or T2DM patients, the fourth quartile of CV-FPG exerted a significant effect on all-cause mortality after simple and full adjustment. A sensitivity analysis excluding participants who died during the first year of follow-up revealed the following results for the highest quartile in the fully adjusted model: overall, HR (95%CI) = 1.54 (1.26–1.89); dysglycemia (prediabetes and T2DM), HR = 1.41 (1.15–1.73); T2DM, HR = 1.36 (1.10–1.67). Conclusion We found CV-FPG to be useful for measurement of GV. It could also be used for the prognostic stratification of patients with dysglycemia
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-07-25
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/707719
https://dx.doi.org/10.1371/journal.pone.0271632
url http://hdl.handle.net/10486/707719
https://dx.doi.org/10.1371/journal.pone.0271632
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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