A micellar formulation of quercetin prevents cisplatin nephrotoxicity

Casanova, Alfredo G.; Prieto, Marta; Colino, Clara I.; Gutiérrez Millán, Carmen; Ruszkowska Ciastek, Barbara; Paz Barragan, Esther De; Gil Martínez, Miguel Ángel; Morales Martin, Ana I.; Lopez Hernandez, Francisco J.

A micellar formulation of quercetin prevents cisplatin nephrotoxicity

Producción Científica

Detalles Bibliográficos
Autores:	Casanova, Alfredo G., Prieto, Marta, Colino, Clara I., Gutiérrez Millán, Carmen, Ruszkowska Ciastek, Barbara, Paz Barragan, Esther De, Gil Martínez, Miguel Ángel, Morales Martin, Ana I., Lopez Hernandez, Francisco J.
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	España
Institución:	Universidad de Valladolid
Repositorio:	UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:	oai:uvadoc.uva.es:10324/59863
Acceso en línea:	https://doi.org/10.3390/ijms22020729 https://uvadoc.uva.es/handle/10324/59863
Access Level:	acceso abierto
Palabra clave:	Cisplatin - Chemotherapy Nephrology Kidneys - Diseases Riñones - Enfermedades - Tratamiento Quercetina - Uso terapéutico Bioavailability Medicamentos - Biodisponibilidad Chemical processes Química - Notación 3208.06 Quimioterapia 3205.06 Nefrología 3303 Ingeniería y Tecnología Químicas

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spelling	A micellar formulation of quercetin prevents cisplatin nephrotoxicityCasanova, Alfredo G.Prieto, MartaColino, Clara I.Gutiérrez Millán, CarmenRuszkowska Ciastek, BarbaraPaz Barragan, Esther DeGil Martínez, Miguel ÁngelMorales Martin, Ana I.Lopez Hernandez, Francisco J.Cisplatin - ChemotherapyNephrologyKidneys - DiseasesRiñones - Enfermedades - TratamientoQuercetina - Uso terapéuticoBioavailabilityMedicamentos - BiodisponibilidadChemical processesQuímica - Notación3208.06 Quimioterapia3205.06 Nefrología3303 Ingeniería y Tecnología QuímicasProducción CientíficaThe antioxidant flavonoid quercetin has been shown to prevent nephrotoxicity in animal models and in a clinical study and is thus a very promising prophylactic candidate under development. Quercetin solubility is very low, which handicaps clinical application. The aim of this work was to study, in rats, the bioavailability and nephroprotective efficacy of a micellar formulation of Pluronic F127-encapsulated quercetin (P-quercetin), with improved hydrosolubility. Intraperitoneal administration of P-quercetin leads to an increased plasma concentration and bioavailability of quercetin compared to the equimolar administration of natural quercetin. Moreover, P-quercetin retains overall nephroprotective properties, and even slightly improves some renal function parameters, when compared to natural quercetin. Specifically, P-quercetin reduced the increment in plasma creatinine (from 3.4 ± 0.5 to 1.2 ± 0.3 mg/dL) and urea (from 490.9 ± 43.8 to 184.1 ± 50.1 mg/dL) and the decrease in creatinine clearance (from 0.08 ± 0.02 to 0.58 ± 0.19 mL/min) induced by the nephrotoxic chemotherapeutic drug cisplatin, and it ameliorated histological evidence of tubular damage. This new formulation with enhanced kinetic and biopharmaceutical properties will allow for further exploration of quercetin as a candidate nephroprotector at lower dosages and by administration routes oriented towards its clinical use.Fundación de Universidades y Enseñanzas Superiores de Castilla y León (FUESCyL) y Banco de Santander - (grant: Ed. 2014– 2015 Desafío UNIV-EMP)Fundación General de la Universidad de Salamanca, Fondo Europeo de Desarrollo Regional (FEDER) y Junta de Castilla y León - (grant: Ed. 2015 Lanzadera TC)Junta de Castilla y León - (grant: VA225U14)MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/ijms22020729https://uvadoc.uva.es/handle/10324/59863reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/1422-0067/22/2/729info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/598632026-06-13T12:44:47Z
dc.title.none.fl_str_mv	A micellar formulation of quercetin prevents cisplatin nephrotoxicity
title	A micellar formulation of quercetin prevents cisplatin nephrotoxicity
spellingShingle	A micellar formulation of quercetin prevents cisplatin nephrotoxicity Casanova, Alfredo G. Cisplatin - Chemotherapy Nephrology Kidneys - Diseases Riñones - Enfermedades - Tratamiento Quercetina - Uso terapéutico Bioavailability Medicamentos - Biodisponibilidad Chemical processes Química - Notación 3208.06 Quimioterapia 3205.06 Nefrología 3303 Ingeniería y Tecnología Químicas
title_short	A micellar formulation of quercetin prevents cisplatin nephrotoxicity
title_full	A micellar formulation of quercetin prevents cisplatin nephrotoxicity
title_fullStr	A micellar formulation of quercetin prevents cisplatin nephrotoxicity
title_full_unstemmed	A micellar formulation of quercetin prevents cisplatin nephrotoxicity
title_sort	A micellar formulation of quercetin prevents cisplatin nephrotoxicity
dc.creator.none.fl_str_mv	Casanova, Alfredo G. Prieto, Marta Colino, Clara I. Gutiérrez Millán, Carmen Ruszkowska Ciastek, Barbara Paz Barragan, Esther De Gil Martínez, Miguel Ángel Morales Martin, Ana I. Lopez Hernandez, Francisco J.
author	Casanova, Alfredo G.
author_facet	Casanova, Alfredo G. Prieto, Marta Colino, Clara I. Gutiérrez Millán, Carmen Ruszkowska Ciastek, Barbara Paz Barragan, Esther De Gil Martínez, Miguel Ángel Morales Martin, Ana I. Lopez Hernandez, Francisco J.
author_role	author
author2	Prieto, Marta Colino, Clara I. Gutiérrez Millán, Carmen Ruszkowska Ciastek, Barbara Paz Barragan, Esther De Gil Martínez, Miguel Ángel Morales Martin, Ana I. Lopez Hernandez, Francisco J.
author2_role	author author author author author author author author
dc.subject.none.fl_str_mv	Cisplatin - Chemotherapy Nephrology Kidneys - Diseases Riñones - Enfermedades - Tratamiento Quercetina - Uso terapéutico Bioavailability Medicamentos - Biodisponibilidad Chemical processes Química - Notación 3208.06 Quimioterapia 3205.06 Nefrología 3303 Ingeniería y Tecnología Químicas
topic	Cisplatin - Chemotherapy Nephrology Kidneys - Diseases Riñones - Enfermedades - Tratamiento Quercetina - Uso terapéutico Bioavailability Medicamentos - Biodisponibilidad Chemical processes Química - Notación 3208.06 Quimioterapia 3205.06 Nefrología 3303 Ingeniería y Tecnología Químicas
description	Producción Científica
publishDate	2021
dc.date.none.fl_str_mv	2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://doi.org/10.3390/ijms22020729 https://uvadoc.uva.es/handle/10324/59863
url	https://doi.org/10.3390/ijms22020729 https://uvadoc.uva.es/handle/10324/59863
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	https://www.mdpi.com/1422-0067/22/2/729
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid instname:Universidad de Valladolid
instname_str	Universidad de Valladolid
reponame_str	UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection	UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,301629

A micellar formulation of quercetin prevents cisplatin nephrotoxicity

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