Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis

HIV; Adolescent; Perinatally acquired

Detalles Bibliográficos
Autores: Jesson, Julie, Crichton, Siobhan, Quartagno, Matteo, Yotebieng, Marcel, abrams, elaine, Chokephaibulkit, Kulkanya, Frick, Marie Antoinette
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/7904
Acceso en línea:https://hdl.handle.net/11351/7904
http://hdl.handle.net/11351/7904
Access Level:acceso abierto
Palabra clave:Infeccions per VIH - Epidemiologia
Adolescents
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Other subheadings::Other subheadings::Other subheadings::/epidemiology
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH
Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología
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oai_identifier_str oai:recercat.cat:11351/7904
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
title Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
spellingShingle Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
Jesson, Julie
Infeccions per VIH - Epidemiologia
Adolescents
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Other subheadings::Other subheadings::Other subheadings::/epidemiology
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH
Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología
title_short Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
title_full Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
title_fullStr Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
title_full_unstemmed Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
title_sort Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
dc.creator.none.fl_str_mv Jesson, Julie
Crichton, Siobhan
Quartagno, Matteo
Yotebieng, Marcel
abrams, elaine
Chokephaibulkit, Kulkanya
Frick, Marie Antoinette
author Jesson, Julie
author_facet Jesson, Julie
Crichton, Siobhan
Quartagno, Matteo
Yotebieng, Marcel
abrams, elaine
Chokephaibulkit, Kulkanya
Frick, Marie Antoinette
author_role author
author2 Crichton, Siobhan
Quartagno, Matteo
Yotebieng, Marcel
abrams, elaine
Chokephaibulkit, Kulkanya
Frick, Marie Antoinette
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Jesson J] CERPOP, Inserm, Université Paul Sabatier Toulouse 3, Toulouse, France. [Crichton S, Quartagno M] MRC Clinical Trials Unit, University College London, London, UK. [Yotebieng M] Division of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA. [Abrams EJ] ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, USA. [Chokephaibulkit K] Siriraj Institute of Clinical Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand. [Frick A] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Infeccions per VIH - Epidemiologia
Adolescents
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Other subheadings::Other subheadings::Other subheadings::/epidemiology
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH
Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología
topic Infeccions per VIH - Epidemiologia
Adolescents
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Other subheadings::Other subheadings::Other subheadings::/epidemiology
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH
Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología
description HIV; Adolescent; Perinatally acquired
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7904
http://hdl.handle.net/11351/7904
url https://hdl.handle.net/11351/7904
http://hdl.handle.net/11351/7904
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of the International AIDS Society;25(3)
https://doi.org/10.1002/jia2.25871
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405213901717504
spelling Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysisJesson, JulieCrichton, SiobhanQuartagno, MatteoYotebieng, Marcelabrams, elaineChokephaibulkit, KulkanyaFrick, Marie AntoinetteInfeccions per VIH - EpidemiologiaAdolescentsDISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV InfectionsOther subheadings::Other subheadings::Other subheadings::/epidemiologyENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIHOtros calificadores::Otros calificadores::Otros calificadores::/epidemiologíaHIV; Adolescent; Perinatally acquiredVIH; Adolescent; Adquirit perinatalmentVIH; Adolescente; Adquirida perinatalmenteIntroduction Adolescents living with HIV are subject to multiple co-morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project. Methods Data were collected between 1994 and 2015 from 11 CIPHER networks worldwide. Adolescents with perinatally acquired HIV infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, with at least one height or CD4 count measurement while aged 10–17 years, were included. Growth was measured using height-for-age Z-scores (HAZ, stunting if <-2 SD, WHO growth charts). Linear mixed-effects models were used to study the evolution of each outcome between ages 10 and 17. For growth, sex-specific models with fractional polynomials were used to model non-linear relationships for age at ART initiation, HAZ at age 10 and time, defined as current age from 10 to 17 years of age. Results A total of 20,939 and 19,557 APH were included for the growth and CD4 analyses, respectively. Half were females, two-thirds lived in East and Southern Africa, and median age at ART initiation ranged from <3 years in North America and Europe to >7 years in sub-Saharan African regions. At age 10, stunting ranged from 6% in North America and Europe to 39% in the Asia-Pacific; 19% overall had CD4 counts <500 cells/mm3. Across adolescence, higher HAZ was observed in females and among those in high-income countries. APH with stunting at age 10 and those with late ART initiation (after age 5) had the largest HAZ gains during adolescence, but these gains were insufficient to catch-up with non-stunted, early ART-treated adolescents. From age 10 to 16 years, mean CD4 counts declined from 768 to 607 cells/mm3. This decline was observed across all regions, in males and females. Conclusions Growth patterns during adolescence differed substantially by sex and region, while CD4 patterns were similar, with an observed CD4 decline that needs further investigation. Early diagnosis and timely initiation of treatment in early childhood to prevent growth retardation and immunodeficiency are critical to improving APH growth and CD4 outcomes by the time they reach adulthood.This work was supported by the International AIDS Society – Collaborative Initiative for Paediatric HIV Education & Research (IAS-CIPHER, http://www.iasociety.org/CIPHER), which is made possible through funding from CIPHER Founding Sponsor ViiV Healthcare (https://www.viivhealthcare.com) and Janssen (http://www.janssen.com).WileyInstitut Català de la Salut[Jesson J] CERPOP, Inserm, Université Paul Sabatier Toulouse 3, Toulouse, France. [Crichton S, Quartagno M] MRC Clinical Trials Unit, University College London, London, UK. [Yotebieng M] Division of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA. [Abrams EJ] ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, USA. [Chokephaibulkit K] Siriraj Institute of Clinical Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand. [Frick A] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7904http://hdl.handle.net/11351/7904Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of the International AIDS Society;25(3)https://doi.org/10.1002/jia2.25871Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/79042026-05-29T05:05:01Z
score 15,811543

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