The Effect of Body Fat Distribution on Systemic Sclerosis

Mendelian randomization; Obesity; Systemic sclerosis

Detalhes bibliográficos
Autores: Callejas, José Luis, López-Isac, Elena, Acosta-Herrera, Marialbert, Villanueva-Martin, Gonzalo, Simeón Aznar, Carmen Pilar, Kerick, Martin
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/8526
Acesso em linha:https://hdl.handle.net/11351/8526
Access Level:acceso abierto
Palavra-chave:Esclerosi sistemàtica progressiva
Obesitat
DISEASES::Skin and Connective Tissue Diseases::Connective Tissue Diseases::Scleroderma, Systemic
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity
ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades del tejido conjuntivo::esclerodermia sistémica
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::sobrepeso::obesidad
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spelling The Effect of Body Fat Distribution on Systemic SclerosisCallejas, José LuisLópez-Isac, ElenaAcosta-Herrera, MarialbertVillanueva-Martin, GonzaloSimeón Aznar, Carmen PilarKerick, MartinEsclerosi sistemàtica progressivaObesitatDISEASES::Skin and Connective Tissue Diseases::Connective Tissue Diseases::Scleroderma, SystemicDISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::ObesityENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades del tejido conjuntivo::esclerodermia sistémicaENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::sobrepeso::obesidadMendelian randomization; Obesity; Systemic sclerosisAleatorización mendeliana; Obesidad; Esclerosis sistémicaAleatorització mendeliana; Obesitat; Esclerosi sistèmicaObesity contributes to a chronic proinflammatory state, which is a known risk factor to develop immune-mediated diseases. However, its role in systemic sclerosis (SSc) remains to be elucidated. Therefore, we conducted a two-sample mendelian randomization (2SMR) study to analyze the effect of three body fat distribution parameters in SSc. As instrumental variables, we used the allele effects described for single nucleotide polymorphisms (SNPs) in different genome-wide association studies (GWAS) for SSc, body mass index (BMI), waist-to-hip ratio (WHR) and WHR adjusted for BMI (WHRadjBMI). We performed local (pHESS) and genome-wide (LDSC) genetic correlation analyses between each of the traits and SSc and we applied several Mendelian randomization (MR) methods (i.e., random effects inverse-variance weight, MR-Egger regression, MR pleiotropy residual sum and outlier method and a multivariable model). Our results show no genetic correlation or causal relationship between any of these traits and SSc. Nevertheless, we observed a negative causal association between WHRadjBMI and SSc, which might be due to the effect of gastrointestinal complications suffered by the majority of SSc patients. In conclusion, reverse causality might be an especially difficult confounding factor to define the effect of obesity in the onset of SSc.This work was supported by grant RTI2018101332-B-100 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” funded by the European Union. Red de Investigación en Inflamación y Enfermedades Reumáticas (RIER) from Instituto de Salud Carlos III (RD16/0012/0013). 115565. LB-C was funded by Grant IJC2018-038026-I funded by MCIN/AEI/10.13039/501100011033. MA-H is a recipient of a Miguel Servet fellowship (CP21/00132) from Instituto de Salud Carlos III (Spanish Ministry of Science and Innovation). EL-I was funded by Grant IJC2019-040080-I funded by MCIN/AEI/10.13039/501100011033. GV-M was funded by Grant PRE2019-087586 funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future”.MDPIInstitut Català de la Salut[Villanueva-Martin G, Kerick M, López-Isac E] Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Spain. [Acosta-Herrera M] Systemic Autoimmune Disease Unit, Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria Ibs, Granada, Spain. [Simeón CP] Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Callejas JL] Department of Internal Medicine, Hospital San Cecilio, Granada, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8526Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésJournal of Clinical Medicine;11(20)https://doi.org/10.3390/jcm11206014Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/85262026-06-12T09:38:37Z
dc.title.none.fl_str_mv The Effect of Body Fat Distribution on Systemic Sclerosis
title The Effect of Body Fat Distribution on Systemic Sclerosis
spellingShingle The Effect of Body Fat Distribution on Systemic Sclerosis
Callejas, José Luis
Esclerosi sistemàtica progressiva
Obesitat
DISEASES::Skin and Connective Tissue Diseases::Connective Tissue Diseases::Scleroderma, Systemic
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity
ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades del tejido conjuntivo::esclerodermia sistémica
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::sobrepeso::obesidad
title_short The Effect of Body Fat Distribution on Systemic Sclerosis
title_full The Effect of Body Fat Distribution on Systemic Sclerosis
title_fullStr The Effect of Body Fat Distribution on Systemic Sclerosis
title_full_unstemmed The Effect of Body Fat Distribution on Systemic Sclerosis
title_sort The Effect of Body Fat Distribution on Systemic Sclerosis
dc.creator.none.fl_str_mv Callejas, José Luis
López-Isac, Elena
Acosta-Herrera, Marialbert
Villanueva-Martin, Gonzalo
Simeón Aznar, Carmen Pilar
Kerick, Martin
author Callejas, José Luis
author_facet Callejas, José Luis
López-Isac, Elena
Acosta-Herrera, Marialbert
Villanueva-Martin, Gonzalo
Simeón Aznar, Carmen Pilar
Kerick, Martin
author_role author
author2 López-Isac, Elena
Acosta-Herrera, Marialbert
Villanueva-Martin, Gonzalo
Simeón Aznar, Carmen Pilar
Kerick, Martin
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Villanueva-Martin G, Kerick M, López-Isac E] Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Spain. [Acosta-Herrera M] Systemic Autoimmune Disease Unit, Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria Ibs, Granada, Spain. [Simeón CP] Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Callejas JL] Department of Internal Medicine, Hospital San Cecilio, Granada, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Esclerosi sistemàtica progressiva
Obesitat
DISEASES::Skin and Connective Tissue Diseases::Connective Tissue Diseases::Scleroderma, Systemic
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity
ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades del tejido conjuntivo::esclerodermia sistémica
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::sobrepeso::obesidad
topic Esclerosi sistemàtica progressiva
Obesitat
DISEASES::Skin and Connective Tissue Diseases::Connective Tissue Diseases::Scleroderma, Systemic
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity
ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades del tejido conjuntivo::esclerodermia sistémica
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::peso corporal::sobrepeso::obesidad
description Mendelian randomization; Obesity; Systemic sclerosis
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8526
url https://hdl.handle.net/11351/8526
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical Medicine;11(20)
https://doi.org/10.3390/jcm11206014
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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