Validation of biomarkers of food intake¿critical assessment of candidate biomarkers

Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promise f...

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Autores: Dragsted, Lars O., Gao, Qian, Scalbert, Augustin, Vergères, Guy, Kolehmainen, Marjukka, Manach, Claudine, Brennan, Lorraine, Afman, Lydia A., Wishart, David S., Andrés Lacueva, Ma. Cristina, Garcia Aloy, Mar, Verhagen, Hans, Feskens, Edith J. M., Praticò, Giulia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/135738
Acceso en línea:https://hdl.handle.net/2445/135738
Access Level:acceso abierto
Palabra clave:Marcadors bioquímics
Nutrició
Metabòlits
Biochemical markers
Nutrition
Metabolites
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spelling Validation of biomarkers of food intake¿critical assessment of candidate biomarkersDragsted, Lars O.Gao, QianScalbert, AugustinVergères, GuyKolehmainen, MarjukkaManach, ClaudineBrennan, LorraineAfman, Lydia A.Wishart, David S.Andrés Lacueva, Ma. CristinaGarcia Aloy, MarVerhagen, HansFeskens, Edith J. M.Praticò, GiuliaMarcadors bioquímicsNutricióMetabòlitsBiochemical markersNutritionMetabolitesBiomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promise for direct and objective measurement of food intake. However, the number of comprehensively validated biomarkers of food intake is limited to just a few. Many new candidate biomarkers emerge from metabolic profiling studies and from advances in food chemistry. Furthermore, candidate food intake biomarkers may also be identified based on extensive literature reviews such as described in the guidelines for Biomarker of Food Intake Reviews (BFIRev). To systematically and critically assess the validity of candidate biomarkers of food intake, it is necessary to outline and streamline an optimal and reproducible validation process. A consensus-based procedure was used to provide and evaluate a set of the most important criteria for systematic validation of BFIs. As a result, a validation procedure was developed including eight criteria, plausibility, dose-response, time-response, robustness, reliability, stability, analytical performance, and inter-laboratory reproducibility. The validation has a dual purpose: (1) to estimate the current level of validation of candidate biomarkers of food intake based on an objective and systematic approach and (2) to pinpoint which additional studies are needed to provide full validation of each candidate biomarker of food intake. This position paper on biomarker of food intake validation outlines the second step of the BFIRev procedure but may also be used as such for validation of new candidate biomarkers identified, e.g., in food metabolomic studies.BioMed Central2019201920182019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/135738Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s12263-018-0603-9Genes & Nutrition, 2018, vol. 13, num. 14, p. 14https://doi.org/10.1186/s12263-018-0603-9info:eu-repo/grantAgreement/EC/H2020/647783info:eu-repo/grantAgreement/EC/FP7/277673cc-by (c) Dragsted, Lars O. et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1357382026-05-29T05:05:01Z
dc.title.none.fl_str_mv Validation of biomarkers of food intake¿critical assessment of candidate biomarkers
title Validation of biomarkers of food intake¿critical assessment of candidate biomarkers
spellingShingle Validation of biomarkers of food intake¿critical assessment of candidate biomarkers
Dragsted, Lars O.
Marcadors bioquímics
Nutrició
Metabòlits
Biochemical markers
Nutrition
Metabolites
title_short Validation of biomarkers of food intake¿critical assessment of candidate biomarkers
title_full Validation of biomarkers of food intake¿critical assessment of candidate biomarkers
title_fullStr Validation of biomarkers of food intake¿critical assessment of candidate biomarkers
title_full_unstemmed Validation of biomarkers of food intake¿critical assessment of candidate biomarkers
title_sort Validation of biomarkers of food intake¿critical assessment of candidate biomarkers
dc.creator.none.fl_str_mv Dragsted, Lars O.
Gao, Qian
Scalbert, Augustin
Vergères, Guy
Kolehmainen, Marjukka
Manach, Claudine
Brennan, Lorraine
Afman, Lydia A.
Wishart, David S.
Andrés Lacueva, Ma. Cristina
Garcia Aloy, Mar
Verhagen, Hans
Feskens, Edith J. M.
Praticò, Giulia
author Dragsted, Lars O.
author_facet Dragsted, Lars O.
Gao, Qian
Scalbert, Augustin
Vergères, Guy
Kolehmainen, Marjukka
Manach, Claudine
Brennan, Lorraine
Afman, Lydia A.
Wishart, David S.
Andrés Lacueva, Ma. Cristina
Garcia Aloy, Mar
Verhagen, Hans
Feskens, Edith J. M.
Praticò, Giulia
author_role author
author2 Gao, Qian
Scalbert, Augustin
Vergères, Guy
Kolehmainen, Marjukka
Manach, Claudine
Brennan, Lorraine
Afman, Lydia A.
Wishart, David S.
Andrés Lacueva, Ma. Cristina
Garcia Aloy, Mar
Verhagen, Hans
Feskens, Edith J. M.
Praticò, Giulia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Marcadors bioquímics
Nutrició
Metabòlits
Biochemical markers
Nutrition
Metabolites
topic Marcadors bioquímics
Nutrició
Metabòlits
Biochemical markers
Nutrition
Metabolites
description Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promise for direct and objective measurement of food intake. However, the number of comprehensively validated biomarkers of food intake is limited to just a few. Many new candidate biomarkers emerge from metabolic profiling studies and from advances in food chemistry. Furthermore, candidate food intake biomarkers may also be identified based on extensive literature reviews such as described in the guidelines for Biomarker of Food Intake Reviews (BFIRev). To systematically and critically assess the validity of candidate biomarkers of food intake, it is necessary to outline and streamline an optimal and reproducible validation process. A consensus-based procedure was used to provide and evaluate a set of the most important criteria for systematic validation of BFIs. As a result, a validation procedure was developed including eight criteria, plausibility, dose-response, time-response, robustness, reliability, stability, analytical performance, and inter-laboratory reproducibility. The validation has a dual purpose: (1) to estimate the current level of validation of candidate biomarkers of food intake based on an objective and systematic approach and (2) to pinpoint which additional studies are needed to provide full validation of each candidate biomarker of food intake. This position paper on biomarker of food intake validation outlines the second step of the BFIRev procedure but may also be used as such for validation of new candidate biomarkers identified, e.g., in food metabolomic studies.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/135738
url https://hdl.handle.net/2445/135738
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s12263-018-0603-9
Genes & Nutrition, 2018, vol. 13, num. 14, p. 14
https://doi.org/10.1186/s12263-018-0603-9
info:eu-repo/grantAgreement/EC/H2020/647783
info:eu-repo/grantAgreement/EC/FP7/277673
dc.rights.none.fl_str_mv cc-by (c) Dragsted, Lars O. et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Dragsted, Lars O. et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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