Early-life chemical exposome: Comprehensive strategies for wide-scope screening of organic compounds
Exposure to organic compounds during early-life stages can disrupt human development and increase susceptibility to adverse health outcomes later in life. Despite evidence of these impacts, research has primarily focused on targeted analyses, missing the complex nature of early-life exposures. Compr...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/366793 |
| Acceso en línea: | http://hdl.handle.net/10261/366793 https://api.elsevier.com/content/abstract/scopus_id/85201284758 |
| Access Level: | acceso abierto |
| Palabra clave: | Wide-scope screening Chemical exposome Early-life Exposomics High-resolution mass spectrometry Non-targeted analysis Suspect screening analysis http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages |
| Sumario: | Exposure to organic compounds during early-life stages can disrupt human development and increase susceptibility to adverse health outcomes later in life. Despite evidence of these impacts, research has primarily focused on targeted analyses, missing the complex nature of early-life exposures. Comprehensive approaches are needed to better characterize these complex mixtures. Recent advances in high-resolution mass spectrometry and computational science have enabled the comprehensive analysis of numerous chemicals through wide-scope screening approaches, yet their application in early-life exposome studies is still limited. This review critically examines studies from the past decade using wide-scope screening to investigate the early-life chemical exposome, emphasizing organic compounds. It evaluates each step of the analytical workflow, including sample collection, preparation, analysis, and data processing, and concludes with recommendations for future research to improve understanding of the early-life chemical exposome and its health implications. |
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