Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses

Background and Objectives: Fetal growth restriction (FGR) is a severe obstetric disease characterized by a low fetal size entailing a set of undesired consequences. For instance, previous studies have noticed a worrisome association between FGR with an abnormal neurodevelopment. However, the precise...

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Authors: Pascual Mancho, Jara, Pintado Recarte, María Del Pilar, Morales Camino, Jorge C., Romero Román, Carlos, Hernández Martín, Concepción, Bravo Arribas, Coral, Bujan, Julia, Álvarez Mon, Melchor, Ortega, Miguel A., De León Luis, Juan Antonio
Format: article
Publication Date:2022
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/73297
Online Access:https://hdl.handle.net/20.500.14352/73297
Access Level:Open access
Keyword:618.2
FGR
BDNF
Umbilical Doppler
Brain sparing
Cord blood
Medicina
Ginecología y obstetricia
Salud pública (Medicina)
32 Ciencias Médicas
3201.08 Ginecología
3212 Salud Pública
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oai_identifier_str oai:docta.ucm.es:20.500.14352/73297
network_acronym_str ES
network_name_str España
repository_id_str
spelling Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age FetusesPascual Mancho, JaraPintado Recarte, María Del PilarMorales Camino, Jorge C.Romero Román, CarlosHernández Martín, ConcepciónBravo Arribas, CoralBujan, JuliaÁlvarez Mon, MelchorOrtega, Miguel A.De León Luis, Juan Antonio618.2FGRBDNFUmbilical DopplerBrain sparingCord bloodMedicinaGinecología y obstetriciaSalud pública (Medicina)32 Ciencias Médicas3201.08 Ginecología3212 Salud PúblicaBackground and Objectives: Fetal growth restriction (FGR) is a severe obstetric disease characterized by a low fetal size entailing a set of undesired consequences. For instance, previous studies have noticed a worrisome association between FGR with an abnormal neurodevelopment. However, the precise link between FGR and neurodevelopmental alterations are not yet fully understood yet. Brain-derived neurotrophic factor (BDNF) is a critical neurotrophin strongly implicated in neurodevelopmental and other neurological processes. In addition, serum levels of BDNF appears to be an interesting indicator of pathological pregnancies, being correlated with the neonatal brain levels. Therefore, the aim of this study is to analyze the blood levels of BDNF in the cord blood from fetuses with FGR in comparison to those with weight appropriate for gestational age (AGA). Materials and Methods: In this study, 130 subjects were recruited: 91 in group A (AGA fetuses); 39 in group B (16 FGR fetuses with exclusively middle cerebral artery (MCA) pulsatility index (PI) < 5th percentile and 23 with umbilical artery (UA) PI > 95th percentile). Serum levels of BDNF were determined through ELISA reactions in these groups. Results: Our results show a significant decrease in cord blood levels of BDNF in FGR and more prominently in those with UA PI >95th percentile in comparison to AGA. FGR fetuses with exclusively decreased MCA PI below the 5th percentile also show reduced levels of BDNF than AGA, although this difference was not statistically significant. Conclusions: Overall, our study reports a potential pathophysiological link between reduced levels of BDNF and neurodevelopmental alterations in fetuses with FGR. However, further studies should be conducted in those FGR subjects with MCA PI < 5th percentile in order to understand the possible implications of BDNF in this group.MDPIUniversidad Complutense de Madrid20222022-01-2120222022-01-21journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/73297reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/732972026-06-02T12:44:21Z
dc.title.none.fl_str_mv Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses
title Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses
spellingShingle Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses
Pascual Mancho, Jara
618.2
FGR
BDNF
Umbilical Doppler
Brain sparing
Cord blood
Medicina
Ginecología y obstetricia
Salud pública (Medicina)
32 Ciencias Médicas
3201.08 Ginecología
3212 Salud Pública
title_short Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses
title_full Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses
title_fullStr Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses
title_full_unstemmed Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses
title_sort Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses
dc.creator.none.fl_str_mv Pascual Mancho, Jara
Pintado Recarte, María Del Pilar
Morales Camino, Jorge C.
Romero Román, Carlos
Hernández Martín, Concepción
Bravo Arribas, Coral
Bujan, Julia
Álvarez Mon, Melchor
Ortega, Miguel A.
De León Luis, Juan Antonio
author Pascual Mancho, Jara
author_facet Pascual Mancho, Jara
Pintado Recarte, María Del Pilar
Morales Camino, Jorge C.
Romero Román, Carlos
Hernández Martín, Concepción
Bravo Arribas, Coral
Bujan, Julia
Álvarez Mon, Melchor
Ortega, Miguel A.
De León Luis, Juan Antonio
author_role author
author2 Pintado Recarte, María Del Pilar
Morales Camino, Jorge C.
Romero Román, Carlos
Hernández Martín, Concepción
Bravo Arribas, Coral
Bujan, Julia
Álvarez Mon, Melchor
Ortega, Miguel A.
De León Luis, Juan Antonio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 618.2
FGR
BDNF
Umbilical Doppler
Brain sparing
Cord blood
Medicina
Ginecología y obstetricia
Salud pública (Medicina)
32 Ciencias Médicas
3201.08 Ginecología
3212 Salud Pública
topic 618.2
FGR
BDNF
Umbilical Doppler
Brain sparing
Cord blood
Medicina
Ginecología y obstetricia
Salud pública (Medicina)
32 Ciencias Médicas
3201.08 Ginecología
3212 Salud Pública
description Background and Objectives: Fetal growth restriction (FGR) is a severe obstetric disease characterized by a low fetal size entailing a set of undesired consequences. For instance, previous studies have noticed a worrisome association between FGR with an abnormal neurodevelopment. However, the precise link between FGR and neurodevelopmental alterations are not yet fully understood yet. Brain-derived neurotrophic factor (BDNF) is a critical neurotrophin strongly implicated in neurodevelopmental and other neurological processes. In addition, serum levels of BDNF appears to be an interesting indicator of pathological pregnancies, being correlated with the neonatal brain levels. Therefore, the aim of this study is to analyze the blood levels of BDNF in the cord blood from fetuses with FGR in comparison to those with weight appropriate for gestational age (AGA). Materials and Methods: In this study, 130 subjects were recruited: 91 in group A (AGA fetuses); 39 in group B (16 FGR fetuses with exclusively middle cerebral artery (MCA) pulsatility index (PI) < 5th percentile and 23 with umbilical artery (UA) PI > 95th percentile). Serum levels of BDNF were determined through ELISA reactions in these groups. Results: Our results show a significant decrease in cord blood levels of BDNF in FGR and more prominently in those with UA PI >95th percentile in comparison to AGA. FGR fetuses with exclusively decreased MCA PI below the 5th percentile also show reduced levels of BDNF than AGA, although this difference was not statistically significant. Conclusions: Overall, our study reports a potential pathophysiological link between reduced levels of BDNF and neurodevelopmental alterations in fetuses with FGR. However, further studies should be conducted in those FGR subjects with MCA PI < 5th percentile in order to understand the possible implications of BDNF in this group.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-21
2022
2022-01-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/73297
url https://hdl.handle.net/20.500.14352/73297
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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