Development of biocompatible and fully bioabsorbable PLA/Mg films for tissue regeneration applications

During recent years, Mg reinforced polylactic acid (PLA) composites have emerged as potential biocompatible and bioabsorbable materials for biomedical applications. It has been shown that Mg particles added to a matrix based on a biodegradable polymer can address the lack of bioactivity and the low...

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Authors: Ferrández-Montero, Ana, Lieblich, Marcela, González-Carrasco, José Luis, Benavente, Rosario, Lorenzo, V., Detsch, R., Boccaccini, A. R., Ferrari, Begoña
Format: article
Status:Versión aceptada para publicación
Publication Date:2019
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/186016
Online Access:http://hdl.handle.net/10261/186016
Access Level:Open access
Keyword:PLA
Tape casting
Tissue regeneration
Magnesium
Film
id ES_2bfe8538f625470f71cc4cb6d7ed4d71
oai_identifier_str oai:digital.csic.es:10261/186016
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Development of biocompatible and fully bioabsorbable PLA/Mg films for tissue regeneration applications
title Development of biocompatible and fully bioabsorbable PLA/Mg films for tissue regeneration applications
spellingShingle Development of biocompatible and fully bioabsorbable PLA/Mg films for tissue regeneration applications
Ferrández-Montero, Ana
PLA
Tape casting
Tissue regeneration
Magnesium
Film
title_short Development of biocompatible and fully bioabsorbable PLA/Mg films for tissue regeneration applications
title_full Development of biocompatible and fully bioabsorbable PLA/Mg films for tissue regeneration applications
title_fullStr Development of biocompatible and fully bioabsorbable PLA/Mg films for tissue regeneration applications
title_full_unstemmed Development of biocompatible and fully bioabsorbable PLA/Mg films for tissue regeneration applications
title_sort Development of biocompatible and fully bioabsorbable PLA/Mg films for tissue regeneration applications
dc.creator.none.fl_str_mv Ferrández-Montero, Ana
Lieblich, Marcela
González-Carrasco, José Luis
Benavente, Rosario
Lorenzo, V.
Detsch, R.
Boccaccini, A. R.
Ferrari, Begoña
author Ferrández-Montero, Ana
author_facet Ferrández-Montero, Ana
Lieblich, Marcela
González-Carrasco, José Luis
Benavente, Rosario
Lorenzo, V.
Detsch, R.
Boccaccini, A. R.
Ferrari, Begoña
author_role author
author2 Lieblich, Marcela
González-Carrasco, José Luis
Benavente, Rosario
Lorenzo, V.
Detsch, R.
Boccaccini, A. R.
Ferrari, Begoña
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Economía y Competitividad (España)
Comunidad de Madrid
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv PLA
Tape casting
Tissue regeneration
Magnesium
Film
topic PLA
Tape casting
Tissue regeneration
Magnesium
Film
description During recent years, Mg reinforced polylactic acid (PLA) composites have emerged as potential biocompatible and bioabsorbable materials for biomedical applications. It has been shown that Mg particles added to a matrix based on a biodegradable polymer can address the lack of bioactivity and the low mechanical properties of the polymers and, furthermore, it can counteract the detrimental effects associated to the high degradation rate of Mg, as alkalinization and elevated H release. Additionally, the polymer can protect the Mg particles, by tailoring their degradation rate. Former processing of these composites performed by extrusion, compression and injection molding employed Mg contents up to 10 wt%. Higher amounts of Mg resulted in heterogeneous materials and thermally degraded matrices, with the corresponding higher degradation rate. In the present work, Mg reinforced PLA films with Mg content as high as 50 wt% were obtained without compromising the thermal stability of the polymer. Firstly, a successful dispersion of Mg microparticles was achieved by a breakthrough in processing introducing a colloidal step where organic additives were added to modify the Mg particle surface and promote a chemically stable suspension. The resulting colloidal suspension was then used as feedstock to obtain composite films by tape casting. The films show advantageous in vitro behaviour in terms of degradation, hydrogen release and oxygen permeability. In addition, the viability with fibroblast cells (MEF) opens a window of opportunity for these composite films as bioabsorbable material for tissue engineering and wound dressing applications. Statement of Significance: Magnesium materials have extraordinary biodegradable properties and bioactive behavior due to release of Mg ions, which offer a promising opportunity for their applicability as biomaterials for tissue regeneration. However, Mg is one of the most reactive metals with a high degradation rate. In contact with water produces H, associated with a risk of failure of the implant. One alternative to minimize this drawback is the use of Mg particles surrounded by a biodegradable biocompatible polymer such as polylactic acid (PLA) to obtain PLA/Mg composites. In this work we processed Mg reinforced PLA in the shape of films that would be suitable for tissue regeneration. In vitro behavior of PLA/Mg films demonstrated that Mg ions increase the fibroblast cells growth.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/186016
url http://hdl.handle.net/10261/186016
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
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info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-63974-C4-1
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2016-79869-C2-1-P
S2018/NMT-4411/ADITIMAT
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PCIN-2017-036
http://dx.doi.org/10.1016/j.actbio.2019.05.026
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling Development of biocompatible and fully bioabsorbable PLA/Mg films for tissue regeneration applicationsFerrández-Montero, AnaLieblich, MarcelaGonzález-Carrasco, José LuisBenavente, RosarioLorenzo, V.Detsch, R.Boccaccini, A. R.Ferrari, BegoñaPLATape castingTissue regenerationMagnesiumFilmDuring recent years, Mg reinforced polylactic acid (PLA) composites have emerged as potential biocompatible and bioabsorbable materials for biomedical applications. It has been shown that Mg particles added to a matrix based on a biodegradable polymer can address the lack of bioactivity and the low mechanical properties of the polymers and, furthermore, it can counteract the detrimental effects associated to the high degradation rate of Mg, as alkalinization and elevated H release. Additionally, the polymer can protect the Mg particles, by tailoring their degradation rate. Former processing of these composites performed by extrusion, compression and injection molding employed Mg contents up to 10 wt%. Higher amounts of Mg resulted in heterogeneous materials and thermally degraded matrices, with the corresponding higher degradation rate. In the present work, Mg reinforced PLA films with Mg content as high as 50 wt% were obtained without compromising the thermal stability of the polymer. Firstly, a successful dispersion of Mg microparticles was achieved by a breakthrough in processing introducing a colloidal step where organic additives were added to modify the Mg particle surface and promote a chemically stable suspension. The resulting colloidal suspension was then used as feedstock to obtain composite films by tape casting. The films show advantageous in vitro behaviour in terms of degradation, hydrogen release and oxygen permeability. In addition, the viability with fibroblast cells (MEF) opens a window of opportunity for these composite films as bioabsorbable material for tissue engineering and wound dressing applications. Statement of Significance: Magnesium materials have extraordinary biodegradable properties and bioactive behavior due to release of Mg ions, which offer a promising opportunity for their applicability as biomaterials for tissue regeneration. However, Mg is one of the most reactive metals with a high degradation rate. In contact with water produces H, associated with a risk of failure of the implant. One alternative to minimize this drawback is the use of Mg particles surrounded by a biodegradable biocompatible polymer such as polylactic acid (PLA) to obtain PLA/Mg composites. In this work we processed Mg reinforced PLA in the shape of films that would be suitable for tissue regeneration. In vitro behavior of PLA/Mg films demonstrated that Mg ions increase the fibroblast cells growth.Financial support of MINECO: MAT2015-63974-C4-1, MAT2016-79869-C2-1-P, MAT2016-79869-C2-1-P (AEI/FEDER, UE), Comunidad de Madrid: ADITIMAT: S2018/NMT-4411, and M-ERA.NET PCIN-2017-036 (MINECO, Spain).Peer ReviewedElsevierAgencia Estatal de Investigación (España)Ministerio de Economía y Competitividad (España)Comunidad de MadridEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2019201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/186016reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#PCIN-2017-036/AEI/10.13039/501100011033info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-63974-C4-1info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2016-79869-C2-1-PS2018/NMT-4411/ADITIMATinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PCIN-2017-036http://dx.doi.org/10.1016/j.actbio.2019.05.026Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1860162026-05-22T06:33:51Z
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