Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes

A high level of subcellular compartmentalization is a hallmark of eukaryotic cells. This intricate internal organization was present already in the common ancestor of all extant eukaryotes, and the determination of the origins and early evolution of the different organelles remains largely elusive....

Descripción completa

Detalles Bibliográficos
Autores: Gabaldón Estevan, Juan Antonio, 1973-, Pittis, Alexandros, 1982-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/26876
Acceso en línea:http://hdl.handle.net/10230/26876
http://dx.doi.org/10.1016/j.biochi.2015.03.021
Access Level:acceso abierto
Palabra clave:Cèl·lules eucariotes
Compartments
Eukaryotes
Evolution
Organelles
id ES_2bfd74341c38b672fdec88caf488dddf
oai_identifier_str oai:repositori.upf.edu:10230/26876
network_acronym_str ES
network_name_str España
repository_id_str
spelling Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotesGabaldón Estevan, Juan Antonio, 1973-Pittis, Alexandros, 1982-Cèl·lules eucariotesCompartmentsEukaryotesEvolutionOrganellesA high level of subcellular compartmentalization is a hallmark of eukaryotic cells. This intricate internal organization was present already in the common ancestor of all extant eukaryotes, and the determination of the origins and early evolution of the different organelles remains largely elusive. Organellar proteomes are determined through regulated pathways that target proteins produced in the cytosol to their final subcellular destinations. This internal sorting of proteins can vary across different physiological conditions, cell types and lineages. Evolutionary retargeting - the alteration of a subcellular localization of a protein in the course of evolution - has been rampant in eukaryotes and involves any possible combination of organelles. This fact adds another layer of difficulty to the reconstruction of the origins and evolution of organelles. In this review we discuss current themes in relation to the origin and evolution of organellar proteomes. Throughout the text, a special focus is set on the evolution of mitochondrial and peroxisomal proteomes, which are two organelles for which extensive proteomic and evolutionary studies have been performed.TG group research is funded in part by a grant from the Spanish ministry of Economy and Competitiveness (BIO2012-37161), a Grant from the Qatar National Research Fund grant (NPRP 5-298-3-086), and a grant from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ ERC (Grant Agreement n. ERC-2012-StG-310325).Elsevier201620162016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/26876http://dx.doi.org/10.1016/j.biochi.2015.03.021reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésBiochimie. 2015; 119(1): 262-268info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161© The Authors. Published by Elsevier B.V. /nThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/268762026-06-12T07:21:37Z
dc.title.none.fl_str_mv Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes
title Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes
spellingShingle Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes
Gabaldón Estevan, Juan Antonio, 1973-
Cèl·lules eucariotes
Compartments
Eukaryotes
Evolution
Organelles
title_short Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes
title_full Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes
title_fullStr Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes
title_full_unstemmed Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes
title_sort Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes
dc.creator.none.fl_str_mv Gabaldón Estevan, Juan Antonio, 1973-
Pittis, Alexandros, 1982-
author Gabaldón Estevan, Juan Antonio, 1973-
author_facet Gabaldón Estevan, Juan Antonio, 1973-
Pittis, Alexandros, 1982-
author_role author
author2 Pittis, Alexandros, 1982-
author2_role author
dc.subject.none.fl_str_mv Cèl·lules eucariotes
Compartments
Eukaryotes
Evolution
Organelles
topic Cèl·lules eucariotes
Compartments
Eukaryotes
Evolution
Organelles
description A high level of subcellular compartmentalization is a hallmark of eukaryotic cells. This intricate internal organization was present already in the common ancestor of all extant eukaryotes, and the determination of the origins and early evolution of the different organelles remains largely elusive. Organellar proteomes are determined through regulated pathways that target proteins produced in the cytosol to their final subcellular destinations. This internal sorting of proteins can vary across different physiological conditions, cell types and lineages. Evolutionary retargeting - the alteration of a subcellular localization of a protein in the course of evolution - has been rampant in eukaryotes and involves any possible combination of organelles. This fact adds another layer of difficulty to the reconstruction of the origins and evolution of organelles. In this review we discuss current themes in relation to the origin and evolution of organellar proteomes. Throughout the text, a special focus is set on the evolution of mitochondrial and peroxisomal proteomes, which are two organelles for which extensive proteomic and evolutionary studies have been performed.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/26876
http://dx.doi.org/10.1016/j.biochi.2015.03.021
url http://hdl.handle.net/10230/26876
http://dx.doi.org/10.1016/j.biochi.2015.03.021
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biochimie. 2015; 119(1): 262-268
info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405198578876416
score 15.81155

Similares en LA Referencia