Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients

Coca Rojo, Armando; Arias Cabrales, Carlos Enrique; Valencia Peláez, Ana Lucia; Burballa Tarrega, Carla Cristina; Bustamante Munguira, Juan; Redondo Pachón, María Dolores; Acosta Ochoa, María Isabel; Crespo Barrio, Marta; Bustamante Bustamante, Jesús; Mendiluce Herrero, Alicia; Pascual Santos, Julio; Pérez Saéz, María José

Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients

Producción Científica

Detalles Bibliográficos
Autores:	Coca Rojo, Armando, Arias Cabrales, Carlos Enrique, Valencia Peláez, Ana Lucia, Burballa Tarrega, Carla Cristina, Bustamante Munguira, Juan, Redondo Pachón, María Dolores, Acosta Ochoa, María Isabel, Crespo Barrio, Marta, Bustamante Bustamante, Jesús, Mendiluce Herrero, Alicia, Pascual Santos, Julio, Pérez Saéz, María José
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2020
País:	España
Institución:	Universidad de Valladolid
Repositorio:	UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:	oai:uvadoc.uva.es:10324/50759
Acceso en línea:	https://doi.org/10.1038/s41598-020-74295-3 https://uvadoc.uva.es/handle/10324/50759
Access Level:	acceso abierto
Palabra clave:	Riñones - Enfermedades - Tratamiento Riñones - Trasplante Survival Supervivencia 3205.06 Nefrología 32 Ciencias Médicas

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spelling	Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipientsCoca Rojo, ArmandoArias Cabrales, Carlos EnriqueValencia Peláez, Ana LuciaBurballa Tarrega, Carla CristinaBustamante Munguira, JuanRedondo Pachón, María DoloresAcosta Ochoa, María IsabelCrespo Barrio, MartaBustamante Bustamante, JesúsMendiluce Herrero, AliciaPascual Santos, JulioPérez Saéz, María JoséRiñones - Enfermedades - TratamientoRiñones - TrasplanteSurvivalSupervivencia3205.06 Nefrología32 Ciencias MédicasProducción CientíficaPre-transplant prognostic scores help to optimize donor/recipient allocation and to minimize organ discard rates. Since most of these scores come from the US, direct application in non-US populations is not advisable. The Survival Benefit Estimator (SBE), built upon the Estimated Post-Transplant Survival (EPTS) and the Kidney Donor Profile Index (KDPI), has not been externally validated. We aimed to examine SBE in a cohort of Spanish kidney transplant recipients. We designed a retrospective cohortbased study of deceased-donor kidney transplants carried out in two different Spanish hospitals. Unadjusted and adjusted Cox models were applied for patient survival. Predictive models were compared using Harrell’s C statistics. SBE, EPTS and KDPI were independently associated with patient survival (p ≤ 0.01 in all models). Model discrimination measured with Harrell’s C statistics ranged from 0.57 (KDPI) to 0.69 (SBE) and 0.71 (EPTS). After adjustment, SBE presented similar calibration and discrimination power to that of EPTS. SBE tended to underestimate actual survival, mainly among high EPTS recipients/high KDPI donors. SBE performed acceptably well at discriminating posttransplant survival in a cohort of Spanish deceased-donor kidney transplant recipients, although its use as the main allocation guide, especially for high KDPI donors or high EPTS recipients requires further testing.Rio Hortega contract (ISCIII-11453)Fondo de Investigaciones Sanitarias - Fondo Europeo de Desarrollo Regional (project PI16/0617)Redinren (project RD16/0009/001)Springer2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1038/s41598-020-74295-3https://uvadoc.uva.es/handle/10324/50759reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.nature.com/articles/s41598-020-74295-3info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/507592026-06-13T12:44:47Z
dc.title.none.fl_str_mv	Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients
title	Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients
spellingShingle	Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients Coca Rojo, Armando Riñones - Enfermedades - Tratamiento Riñones - Trasplante Survival Supervivencia 3205.06 Nefrología 32 Ciencias Médicas
title_short	Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients
title_full	Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients
title_fullStr	Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients
title_full_unstemmed	Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients
title_sort	Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients
dc.creator.none.fl_str_mv	Coca Rojo, Armando Arias Cabrales, Carlos Enrique Valencia Peláez, Ana Lucia Burballa Tarrega, Carla Cristina Bustamante Munguira, Juan Redondo Pachón, María Dolores Acosta Ochoa, María Isabel Crespo Barrio, Marta Bustamante Bustamante, Jesús Mendiluce Herrero, Alicia Pascual Santos, Julio Pérez Saéz, María José
author	Coca Rojo, Armando
author_facet	Coca Rojo, Armando Arias Cabrales, Carlos Enrique Valencia Peláez, Ana Lucia Burballa Tarrega, Carla Cristina Bustamante Munguira, Juan Redondo Pachón, María Dolores Acosta Ochoa, María Isabel Crespo Barrio, Marta Bustamante Bustamante, Jesús Mendiluce Herrero, Alicia Pascual Santos, Julio Pérez Saéz, María José
author_role	author
author2	Arias Cabrales, Carlos Enrique Valencia Peláez, Ana Lucia Burballa Tarrega, Carla Cristina Bustamante Munguira, Juan Redondo Pachón, María Dolores Acosta Ochoa, María Isabel Crespo Barrio, Marta Bustamante Bustamante, Jesús Mendiluce Herrero, Alicia Pascual Santos, Julio Pérez Saéz, María José
author2_role	author author author author author author author author author author author
dc.subject.none.fl_str_mv	Riñones - Enfermedades - Tratamiento Riñones - Trasplante Survival Supervivencia 3205.06 Nefrología 32 Ciencias Médicas
topic	Riñones - Enfermedades - Tratamiento Riñones - Trasplante Survival Supervivencia 3205.06 Nefrología 32 Ciencias Médicas
description	Producción Científica
publishDate	2020
dc.date.none.fl_str_mv	2020
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://doi.org/10.1038/s41598-020-74295-3 https://uvadoc.uva.es/handle/10324/50759
url	https://doi.org/10.1038/s41598-020-74295-3 https://uvadoc.uva.es/handle/10324/50759
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	https://www.nature.com/articles/s41598-020-74295-3
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Springer
publisher.none.fl_str_mv	Springer
dc.source.none.fl_str_mv	reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid instname:Universidad de Valladolid
instname_str	Universidad de Valladolid
reponame_str	UVaDOC. Repositorio Documental de la Universidad de Valladolid
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Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients

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