Liquid biopsy: circulating tumor cells utility in precision medicine

Metastatic disease is the leading cause of cancer associated deaths. Circulating tumour cells (CTCs) are responsible for tumoral dissemination, as they are able to be released from the primary tumour and establish distal metastatic foci. The objective of this doctoral thesis is to increase the knowl...

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Detalles Bibliográficos
Autor: Pereira Veiga, Tais
Tipo de recurso: tesis doctoral
Fecha de publicación:2019
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/19470
Acceso en línea:http://hdl.handle.net/10347/19470
Access Level:acceso abierto
Palabra clave:Materias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320101 Oncología
Materias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320899 biopsia líquida
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spelling Liquid biopsy: circulating tumor cells utility in precision medicinePereira Veiga, TaisMaterias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320101 OncologíaMaterias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320899 biopsia líquidaMetastatic disease is the leading cause of cancer associated deaths. Circulating tumour cells (CTCs) are responsible for tumoral dissemination, as they are able to be released from the primary tumour and establish distal metastatic foci. The objective of this doctoral thesis is to increase the knowledge of CTCs, through the use of liquid biopsy. To this aim, with the use of blood samples from metastatic cancer patients we identified key biomarkers for cancer progression. In this context, different experimental approaches were considered: the validation of new technologies for the study of CTCs, the isolation and molecular analysis of CTCs and the establishment of in vivo models.Costa Nogueira, ClotildeMuinelo Romay, LauraLópez López, RafaelUniversidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde20192019-01-0120192019-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/19470reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/194702026-06-15T12:47:27Z
dc.title.none.fl_str_mv Liquid biopsy: circulating tumor cells utility in precision medicine
title Liquid biopsy: circulating tumor cells utility in precision medicine
spellingShingle Liquid biopsy: circulating tumor cells utility in precision medicine
Pereira Veiga, Tais
Materias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320101 Oncología
Materias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320899 biopsia líquida
title_short Liquid biopsy: circulating tumor cells utility in precision medicine
title_full Liquid biopsy: circulating tumor cells utility in precision medicine
title_fullStr Liquid biopsy: circulating tumor cells utility in precision medicine
title_full_unstemmed Liquid biopsy: circulating tumor cells utility in precision medicine
title_sort Liquid biopsy: circulating tumor cells utility in precision medicine
dc.creator.none.fl_str_mv Pereira Veiga, Tais
author Pereira Veiga, Tais
author_facet Pereira Veiga, Tais
author_role author
dc.contributor.none.fl_str_mv Costa Nogueira, Clotilde
Muinelo Romay, Laura
López López, Rafael
Universidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde
dc.subject.none.fl_str_mv Materias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320101 Oncología
Materias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320899 biopsia líquida
topic Materias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320101 Oncología
Materias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320899 biopsia líquida
description Metastatic disease is the leading cause of cancer associated deaths. Circulating tumour cells (CTCs) are responsible for tumoral dissemination, as they are able to be released from the primary tumour and establish distal metastatic foci. The objective of this doctoral thesis is to increase the knowledge of CTCs, through the use of liquid biopsy. To this aim, with the use of blood samples from metastatic cancer patients we identified key biomarkers for cancer progression. In this context, different experimental approaches were considered: the validation of new technologies for the study of CTCs, the isolation and molecular analysis of CTCs and the establishment of in vivo models.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/19470
url http://hdl.handle.net/10347/19470
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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