Thermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting Nanoparticles

Lanthanide-based upconverting nanoparticles (UCNPs) are trustworthy workhorses in luminescent nanothermometry. The use of UCNPs-based nanothermometers has enabled the determination of the thermal properties of cell membranes and monitoring of in vivo thermal therapies in real time. However, UCNPs bo...

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Authors: Lu, Dasheng, Rubio Retama, Benito Jorge, Marin, Riccardo, Marqués Ponce, Manuel Ignacio, Gómez Calderón, Óscar, Melle Hernández, Sonia, Haro González, Patricia, Jaque García, Daniel, Bandrés Ponce, Francisco Javier
Format: article
Publication Date:2022
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/73319
Online Access:https://hdl.handle.net/20.500.14352/73319
Access Level:Open access
Keyword:539.2:620.1
535.37
Luminescent nanothermometry
Optical force
Optical trapping
Poly(N-isopropylacrylamide)
Surface modification
Thermal sensitivity
Upconverting nanoparticles.
Física de materiales
Óptica (Física)
Óptica física, óptica cuántica
2209.19 Óptica Física
2209.19 Óptica física
id ES_2bf7e47484f69d5707bc94a9b2efca86
oai_identifier_str oai:docta.ucm.es:20.500.14352/73319
network_acronym_str ES
network_name_str España
repository_id_str
spelling Thermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting NanoparticlesLu, DashengRubio Retama, Benito JorgeMarin, RiccardoMarqués Ponce, Manuel IgnacioGómez Calderón, ÓscarMelle Hernández, SoniaHaro González, PatriciaJaque García, DanielBandrés Ponce, Francisco Javier539.2:620.1535.37Luminescent nanothermometryOptical forceOptical trappingPoly(N-isopropylacrylamide)Surface modificationThermal sensitivityUpconverting nanoparticles.Física de materialesÓptica (Física)Óptica física, óptica cuántica2209.19 Óptica Física2209.19 Óptica físicaLanthanide-based upconverting nanoparticles (UCNPs) are trustworthy workhorses in luminescent nanothermometry. The use of UCNPs-based nanothermometers has enabled the determination of the thermal properties of cell membranes and monitoring of in vivo thermal therapies in real time. However, UCNPs boast low thermal sensitivity and brightness, which, along with the difficulty in controlling individual UCNP remotely, make them less than ideal nanothermometers at the single-particle level. In this work, it is shown how these problems can be elegantly solved using a thermoresponsive polymeric coating. Upon decorating the surface of NaYF4 :Er3+ ,Yb3+ UCNPs with poly(N-isopropylacrylamide) (PNIPAM), a >10-fold enhancement in optical forces is observed, allowing stable trapping and manipulation of a single UCNP in the physiological temperature range (20-45 °C). This optical force improvement is accompanied by a significant enhancement of the thermal sensitivity- a maximum value of 8% °C+1 at 32 °C induced by the collapse of PNIPAM. Numerical simulations reveal that the enhancement in thermal sensitivity mainly stems from the high-refractive-index polymeric coating that behaves as a nanolens of high numerical aperture. The results in this work demonstrate how UCNP nanothermometers can be further improved by an adequate surface decoration and open a new avenue toward highly sensitive single-particle nanothermometry.WileyUniversidad Complutense de Madrid20222022-07-3020222022-07-30journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/73319reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/733192026-06-02T12:44:21Z
dc.title.none.fl_str_mv Thermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting Nanoparticles
title Thermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting Nanoparticles
spellingShingle Thermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting Nanoparticles
Lu, Dasheng
539.2:620.1
535.37
Luminescent nanothermometry
Optical force
Optical trapping
Poly(N-isopropylacrylamide)
Surface modification
Thermal sensitivity
Upconverting nanoparticles.
Física de materiales
Óptica (Física)
Óptica física, óptica cuántica
2209.19 Óptica Física
2209.19 Óptica física
title_short Thermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting Nanoparticles
title_full Thermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting Nanoparticles
title_fullStr Thermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting Nanoparticles
title_full_unstemmed Thermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting Nanoparticles
title_sort Thermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting Nanoparticles
dc.creator.none.fl_str_mv Lu, Dasheng
Rubio Retama, Benito Jorge
Marin, Riccardo
Marqués Ponce, Manuel Ignacio
Gómez Calderón, Óscar
Melle Hernández, Sonia
Haro González, Patricia
Jaque García, Daniel
Bandrés Ponce, Francisco Javier
author Lu, Dasheng
author_facet Lu, Dasheng
Rubio Retama, Benito Jorge
Marin, Riccardo
Marqués Ponce, Manuel Ignacio
Gómez Calderón, Óscar
Melle Hernández, Sonia
Haro González, Patricia
Jaque García, Daniel
Bandrés Ponce, Francisco Javier
author_role author
author2 Rubio Retama, Benito Jorge
Marin, Riccardo
Marqués Ponce, Manuel Ignacio
Gómez Calderón, Óscar
Melle Hernández, Sonia
Haro González, Patricia
Jaque García, Daniel
Bandrés Ponce, Francisco Javier
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 539.2:620.1
535.37
Luminescent nanothermometry
Optical force
Optical trapping
Poly(N-isopropylacrylamide)
Surface modification
Thermal sensitivity
Upconverting nanoparticles.
Física de materiales
Óptica (Física)
Óptica física, óptica cuántica
2209.19 Óptica Física
2209.19 Óptica física
topic 539.2:620.1
535.37
Luminescent nanothermometry
Optical force
Optical trapping
Poly(N-isopropylacrylamide)
Surface modification
Thermal sensitivity
Upconverting nanoparticles.
Física de materiales
Óptica (Física)
Óptica física, óptica cuántica
2209.19 Óptica Física
2209.19 Óptica física
description Lanthanide-based upconverting nanoparticles (UCNPs) are trustworthy workhorses in luminescent nanothermometry. The use of UCNPs-based nanothermometers has enabled the determination of the thermal properties of cell membranes and monitoring of in vivo thermal therapies in real time. However, UCNPs boast low thermal sensitivity and brightness, which, along with the difficulty in controlling individual UCNP remotely, make them less than ideal nanothermometers at the single-particle level. In this work, it is shown how these problems can be elegantly solved using a thermoresponsive polymeric coating. Upon decorating the surface of NaYF4 :Er3+ ,Yb3+ UCNPs with poly(N-isopropylacrylamide) (PNIPAM), a >10-fold enhancement in optical forces is observed, allowing stable trapping and manipulation of a single UCNP in the physiological temperature range (20-45 °C). This optical force improvement is accompanied by a significant enhancement of the thermal sensitivity- a maximum value of 8% °C+1 at 32 °C induced by the collapse of PNIPAM. Numerical simulations reveal that the enhancement in thermal sensitivity mainly stems from the high-refractive-index polymeric coating that behaves as a nanolens of high numerical aperture. The results in this work demonstrate how UCNP nanothermometers can be further improved by an adequate surface decoration and open a new avenue toward highly sensitive single-particle nanothermometry.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-07-30
2022
2022-07-30
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/73319
url https://hdl.handle.net/20.500.14352/73319
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405196935757824
score 15,300719

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