The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank study

Frailty in older adults, particularly those with chronic diseases, has a robust association with risk of mortality, but whether this is the case in middle-aged adults is unclear. We examined the frailty-mortality association in middle-aged adults with chronic diseases and multimorbidity. Data on Fri...

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Autores: Dastouet J, Fayosse A, Jacob L, Singh-Manoux A, Sabia S, Landré B
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p29549
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29549
Access Level:acceso abierto
Palabra clave:Ageing
Frailty
Chronic disease
Multimorbidity
Mortality
UK Biobank
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spelling The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank studyDastouet JFayosse AJacob LSingh-Manoux ASabia SLandré BAgeingFrailtyChronic diseaseMultimorbidityMortalityUK BiobankFrailty in older adults, particularly those with chronic diseases, has a robust association with risk of mortality, but whether this is the case in middle-aged adults is unclear. We examined the frailty-mortality association in middle-aged adults with chronic diseases and multimorbidity. Data on Fried's frailty phenotype (robust, prefrail, frail) and 47 chronic diseases, mapped to 13 body organ systems, was available on 230,960 participants of the UK Biobank study (mean age 57.8, range 38.0-72.0). The mortality follow-up was 13.3 (+/- 2.1) years, and associations with mortality were examined using Cox regression, adjusted for socio-demographic factors and health behaviours. Compared to the robust group, frailty (HR, 2.32 (95% confidence intervals, 2.21; 2.43)) and prefrailty (1.35 (1.31; 1.39)) in those with diseases in any body organ system had a higher risk of mortality. Frailty was associated with a higher mortality risk for all 13 groups (all p < 0.01); estimates ranged from 2.25 (2.12; 2.39) for circulatory system diseases to 2.97 (2.60; 3.39) for the eye system. The same was the case for prefrailty; estimates ranged from 1.33 (1.23; 1.43) to 1.61 (1.03; 2.51). Between 19 and 34% of the mortality risk in the 13 disease groups could potentially be explained by frailty/prefrailty. Frailty (p < 0.01) and prefrailty (p < 0.01) had stronger associations with mortality in those with diseases affecting multiple organ systems. These findings highlight the importance of frailty in middle-aged adults with chronic diseases, suggesting that a third of the excess risk of mortality could potentially be addressed by improving frailty status.SPRINGER2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29549GeroScienceISSN: 25092715ISSNe: 25092723reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p295492026-05-27T12:37:41Z
dc.title.none.fl_str_mv The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank study
title The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank study
spellingShingle The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank study
Dastouet J
Ageing
Frailty
Chronic disease
Multimorbidity
Mortality
UK Biobank
title_short The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank study
title_full The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank study
title_fullStr The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank study
title_full_unstemmed The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank study
title_sort The frailty mortality link in people with chronic diseases pertaining to 13 body organ systems: findings from the UK Biobank study
dc.creator.none.fl_str_mv Dastouet J
Fayosse A
Jacob L
Singh-Manoux A
Sabia S
Landré B
author Dastouet J
author_facet Dastouet J
Fayosse A
Jacob L
Singh-Manoux A
Sabia S
Landré B
author_role author
author2 Fayosse A
Jacob L
Singh-Manoux A
Sabia S
Landré B
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ageing
Frailty
Chronic disease
Multimorbidity
Mortality
UK Biobank
topic Ageing
Frailty
Chronic disease
Multimorbidity
Mortality
UK Biobank
description Frailty in older adults, particularly those with chronic diseases, has a robust association with risk of mortality, but whether this is the case in middle-aged adults is unclear. We examined the frailty-mortality association in middle-aged adults with chronic diseases and multimorbidity. Data on Fried's frailty phenotype (robust, prefrail, frail) and 47 chronic diseases, mapped to 13 body organ systems, was available on 230,960 participants of the UK Biobank study (mean age 57.8, range 38.0-72.0). The mortality follow-up was 13.3 (+/- 2.1) years, and associations with mortality were examined using Cox regression, adjusted for socio-demographic factors and health behaviours. Compared to the robust group, frailty (HR, 2.32 (95% confidence intervals, 2.21; 2.43)) and prefrailty (1.35 (1.31; 1.39)) in those with diseases in any body organ system had a higher risk of mortality. Frailty was associated with a higher mortality risk for all 13 groups (all p < 0.01); estimates ranged from 2.25 (2.12; 2.39) for circulatory system diseases to 2.97 (2.60; 3.39) for the eye system. The same was the case for prefrailty; estimates ranged from 1.33 (1.23; 1.43) to 1.61 (1.03; 2.51). Between 19 and 34% of the mortality risk in the 13 disease groups could potentially be explained by frailty/prefrailty. Frailty (p < 0.01) and prefrailty (p < 0.01) had stronger associations with mortality in those with diseases affecting multiple organ systems. These findings highlight the importance of frailty in middle-aged adults with chronic diseases, suggesting that a third of the excess risk of mortality could potentially be addressed by improving frailty status.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29549
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER
publisher.none.fl_str_mv SPRINGER
dc.source.none.fl_str_mv GeroScience
ISSN: 25092715
ISSNe: 25092723
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
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