Residential proximity to green spaces and breast cancer risk: The multicase-control study in Spain (MCC-Spain)

Background: Breast cancer is the main cause of cancer mortality among women. Green spaces have been recently associated with reduced cancer mortality among women. Mechanisms explaining the beneficial effect of green spaces include increased levels of physical activity and reduced exposure to air pol...

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Autores: O'Callaghan-Gordo, Cristina, Kogevinas, Manolis, Cirach, Marta, Castaño Vinyals, Gemma, Gràcia Lavedan, Esther, Espinosa, Ana, Valentín, Antònia, Nieuwenhuijsen, Mark J.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/42158
Acceso en línea:http://hdl.handle.net/10230/42158
http://dx.doi.org/10.1016/j.ijheh.2018.07.014
Access Level:acceso abierto
Palabra clave:Air pollution
Breast cancer
Case-control study
Green spaces
Physical activity
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spelling Residential proximity to green spaces and breast cancer risk: The multicase-control study in Spain (MCC-Spain)O'Callaghan-Gordo, CristinaKogevinas, ManolisCirach, MartaCastaño Vinyals, GemmaGràcia Lavedan, EstherEspinosa, AnaValentín, AntòniaNieuwenhuijsen, Mark J.Air pollutionBreast cancerCase-control studyGreen spacesPhysical activityBackground: Breast cancer is the main cause of cancer mortality among women. Green spaces have been recently associated with reduced cancer mortality among women. Mechanisms explaining the beneficial effect of green spaces include increased levels of physical activity and reduced exposure to air pollution, which have been both associated with cancer development. Objectives: To investigate the associations between presence of urban green areas, presence of agricultural areas and surrounding greenness and risk of breast cancer, and to assess whether these associations are mediated by physical activity and/or air pollution levels. Methods: We geocoded the current residence of 1129 breast cancer cases and 1619 controls recruited between 2008 and 2013 in ten provinces of Spain, as part of the MCC-Spain study. We assigned different indicators of exposure to green spaces in a buffer of 300 m, and in nested buffers of 100 m and 500 m around the residence: presence of urban green areas according to Urban Atlas, presence of agricultural areas according to CORINE Land Cover 2006, and surrounding greenness according to the average of the Normalized Difference Vegetation Index. We used logistic mixed-effects regression models with a random effect for hospital adjusting for potential confounders. We explored the effect of several potential effect modifiers. We assessed mediation effect by physical activity and levels of air pollution. Results: Presence of urban green areas was associated with reduced risk of breast cancer after adjusting for age, socio-economic status at individual and at area level, education, and number of children [OR (95%CI) = 0.65 (0.49–0.86)]. There was evidence of a linear trend between distance to urban green areas and risk of breast cancer. On the contrary, presence of agricultural areas and surrounding greenness were associated with increased risk of breast cancer [adjusted OR (95%CI) = 1.33 (1.07–1.65) and adjusted OR (95%CI) = 1.27 (0.92–1.77), respectively]. None of the associations observed were mediated by levels of physical activity or levels or air pollution. Conclusions: The association between green spaces and risk of breast cancer is dependent on land-use. The confirmation of these results in other settings and the study of potential mechanisms for the associations observed are needed to advance the understanding on the potential effects of green spaces on health.Elsevier20192018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/42158http://dx.doi.org/10.1016/j.ijheh.2018.07.014reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInternational Journal of Hygiene and Environmental Health. 2018;221(8):1097-106© Elsevier http://dx.doi.org/10.1016/j.ijheh.2018.07.014info:eu-repo/semantics/openAccessoai:recercat.cat:10230/421582026-05-29T05:05:01Z
dc.title.none.fl_str_mv Residential proximity to green spaces and breast cancer risk: The multicase-control study in Spain (MCC-Spain)
title Residential proximity to green spaces and breast cancer risk: The multicase-control study in Spain (MCC-Spain)
spellingShingle Residential proximity to green spaces and breast cancer risk: The multicase-control study in Spain (MCC-Spain)
O'Callaghan-Gordo, Cristina
Air pollution
Breast cancer
Case-control study
Green spaces
Physical activity
title_short Residential proximity to green spaces and breast cancer risk: The multicase-control study in Spain (MCC-Spain)
title_full Residential proximity to green spaces and breast cancer risk: The multicase-control study in Spain (MCC-Spain)
title_fullStr Residential proximity to green spaces and breast cancer risk: The multicase-control study in Spain (MCC-Spain)
title_full_unstemmed Residential proximity to green spaces and breast cancer risk: The multicase-control study in Spain (MCC-Spain)
title_sort Residential proximity to green spaces and breast cancer risk: The multicase-control study in Spain (MCC-Spain)
dc.creator.none.fl_str_mv O'Callaghan-Gordo, Cristina
Kogevinas, Manolis
Cirach, Marta
Castaño Vinyals, Gemma
Gràcia Lavedan, Esther
Espinosa, Ana
Valentín, Antònia
Nieuwenhuijsen, Mark J.
author O'Callaghan-Gordo, Cristina
author_facet O'Callaghan-Gordo, Cristina
Kogevinas, Manolis
Cirach, Marta
Castaño Vinyals, Gemma
Gràcia Lavedan, Esther
Espinosa, Ana
Valentín, Antònia
Nieuwenhuijsen, Mark J.
author_role author
author2 Kogevinas, Manolis
Cirach, Marta
Castaño Vinyals, Gemma
Gràcia Lavedan, Esther
Espinosa, Ana
Valentín, Antònia
Nieuwenhuijsen, Mark J.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Air pollution
Breast cancer
Case-control study
Green spaces
Physical activity
topic Air pollution
Breast cancer
Case-control study
Green spaces
Physical activity
description Background: Breast cancer is the main cause of cancer mortality among women. Green spaces have been recently associated with reduced cancer mortality among women. Mechanisms explaining the beneficial effect of green spaces include increased levels of physical activity and reduced exposure to air pollution, which have been both associated with cancer development. Objectives: To investigate the associations between presence of urban green areas, presence of agricultural areas and surrounding greenness and risk of breast cancer, and to assess whether these associations are mediated by physical activity and/or air pollution levels. Methods: We geocoded the current residence of 1129 breast cancer cases and 1619 controls recruited between 2008 and 2013 in ten provinces of Spain, as part of the MCC-Spain study. We assigned different indicators of exposure to green spaces in a buffer of 300 m, and in nested buffers of 100 m and 500 m around the residence: presence of urban green areas according to Urban Atlas, presence of agricultural areas according to CORINE Land Cover 2006, and surrounding greenness according to the average of the Normalized Difference Vegetation Index. We used logistic mixed-effects regression models with a random effect for hospital adjusting for potential confounders. We explored the effect of several potential effect modifiers. We assessed mediation effect by physical activity and levels of air pollution. Results: Presence of urban green areas was associated with reduced risk of breast cancer after adjusting for age, socio-economic status at individual and at area level, education, and number of children [OR (95%CI) = 0.65 (0.49–0.86)]. There was evidence of a linear trend between distance to urban green areas and risk of breast cancer. On the contrary, presence of agricultural areas and surrounding greenness were associated with increased risk of breast cancer [adjusted OR (95%CI) = 1.33 (1.07–1.65) and adjusted OR (95%CI) = 1.27 (0.92–1.77), respectively]. None of the associations observed were mediated by levels of physical activity or levels or air pollution. Conclusions: The association between green spaces and risk of breast cancer is dependent on land-use. The confirmation of these results in other settings and the study of potential mechanisms for the associations observed are needed to advance the understanding on the potential effects of green spaces on health.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/42158
http://dx.doi.org/10.1016/j.ijheh.2018.07.014
url http://hdl.handle.net/10230/42158
http://dx.doi.org/10.1016/j.ijheh.2018.07.014
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Hygiene and Environmental Health. 2018;221(8):1097-106
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.ijheh.2018.07.014
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.ijheh.2018.07.014
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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