Urocortin-2 prevents dysregulation of Ca2+ homeostasis and improves early cardiac remodeling after ischemia and reperfusion

[Aims] Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is known about its role in the regulation of intracellular Ca2+ concentration ([Ca2+]i) under I/R. Here, we examined whether the addition of Ucn-2 in reperfusion promotes cardiopro...

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Detalles Bibliográficos
Autores: Domínguez-Rodríguez, Alejandro, Mayoral-González, Isabel, Ávila-Medina, Javier, Rojas-de Pedro, Eva S. de, Calderón-Sánchez, Eva, Díaz Carrasco, Ignacio, Hmadcha, Abdelkrim, Castellano, Antonio, Rosado, Juan A., Benitah, Jean-Pierre, Gómez, Ana M., Ordóñez Fernández, Antonio, Smani, Tarik
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/180270
Acceso en línea:http://hdl.handle.net/10261/180270
Access Level:acceso abierto
Palabra clave:Urocortin-2
Ischemia and reperfusion
Adverse remodeling
Ca2+ dysregulation
Store operated Ca2+ channels
Descripción
Sumario:[Aims] Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is known about its role in the regulation of intracellular Ca2+ concentration ([Ca2+]i) under I/R. Here, we examined whether the addition of Ucn-2 in reperfusion promotes cardioprotection focusing on ([Ca2+]i handling.

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