Candida duobushaemulonii: An Old But Unreported Pathogen

Candidiasis caused by species of the Candida haemulonii complex (Candida haemulonii and Candida duobushaemulonii) and closely related species, Candida auris and Candida pseudohaemulonii are increasing. These species often show reduced susceptibility to antifungal drugs, such as azoles and amphoteric...

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Detalles Bibliográficos
Autores: Jurado Martín, Irene, Marcos Arias, Cristina, Tamayo, Esther, Guridi, Andrea, de Groot, Petrus Wilhelmus Johannes, Quindós, Guillermo, Eraso, Elena
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/46958
Acceso en línea:https://www.mdpi.com/2309-608X/6/4/374
https://hdl.handle.net/10578/46958
Access Level:acceso abierto
Palabra clave:Candida duobushaemulonii
Candida haemulonii complex
Misidentification
Molecular identification
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spelling Candida duobushaemulonii: An Old But Unreported PathogenJurado Martín, IreneMarcos Arias, CristinaTamayo, EstherGuridi, Andreade Groot, Petrus Wilhelmus JohannesQuindós, GuillermoEraso, ElenaCandida duobushaemuloniiCandida haemulonii complexMisidentificationMolecular identificationCandidiasis caused by species of the Candida haemulonii complex (Candida haemulonii and Candida duobushaemulonii) and closely related species, Candida auris and Candida pseudohaemulonii are increasing. These species often show reduced susceptibility to antifungal drugs, such as azoles and amphotericin B or, less frequently, echinocandins. However, conventional phenotypic identification methods are unable to accurately differentiate these species and, therefore, their prevalence may have been underestimated. In this study, 150 isolates that were probably misidentified were reanalyzed using two novel PCR approaches. We found that one isolate previously identified in 1996 as Candida intermedia was C. duobushaemulonii, being one of the oldest isolates of this species described to date. We also found that this isolate had reduced susceptibility to fluconazole, itraconazole, and amphotericin BMDPI202620262020info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://www.mdpi.com/2309-608X/6/4/374https://hdl.handle.net/10578/46958reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésSAF2017-86188-PGIC15/78 IT-990-16info:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/469582026-05-27T07:36:41Z
dc.title.none.fl_str_mv Candida duobushaemulonii: An Old But Unreported Pathogen
title Candida duobushaemulonii: An Old But Unreported Pathogen
spellingShingle Candida duobushaemulonii: An Old But Unreported Pathogen
Jurado Martín, Irene
Candida duobushaemulonii
Candida haemulonii complex
Misidentification
Molecular identification
title_short Candida duobushaemulonii: An Old But Unreported Pathogen
title_full Candida duobushaemulonii: An Old But Unreported Pathogen
title_fullStr Candida duobushaemulonii: An Old But Unreported Pathogen
title_full_unstemmed Candida duobushaemulonii: An Old But Unreported Pathogen
title_sort Candida duobushaemulonii: An Old But Unreported Pathogen
dc.creator.none.fl_str_mv Jurado Martín, Irene
Marcos Arias, Cristina
Tamayo, Esther
Guridi, Andrea
de Groot, Petrus Wilhelmus Johannes
Quindós, Guillermo
Eraso, Elena
author Jurado Martín, Irene
author_facet Jurado Martín, Irene
Marcos Arias, Cristina
Tamayo, Esther
Guridi, Andrea
de Groot, Petrus Wilhelmus Johannes
Quindós, Guillermo
Eraso, Elena
author_role author
author2 Marcos Arias, Cristina
Tamayo, Esther
Guridi, Andrea
de Groot, Petrus Wilhelmus Johannes
Quindós, Guillermo
Eraso, Elena
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Candida duobushaemulonii
Candida haemulonii complex
Misidentification
Molecular identification
topic Candida duobushaemulonii
Candida haemulonii complex
Misidentification
Molecular identification
description Candidiasis caused by species of the Candida haemulonii complex (Candida haemulonii and Candida duobushaemulonii) and closely related species, Candida auris and Candida pseudohaemulonii are increasing. These species often show reduced susceptibility to antifungal drugs, such as azoles and amphotericin B or, less frequently, echinocandins. However, conventional phenotypic identification methods are unable to accurately differentiate these species and, therefore, their prevalence may have been underestimated. In this study, 150 isolates that were probably misidentified were reanalyzed using two novel PCR approaches. We found that one isolate previously identified in 1996 as Candida intermedia was C. duobushaemulonii, being one of the oldest isolates of this species described to date. We also found that this isolate had reduced susceptibility to fluconazole, itraconazole, and amphotericin B
publishDate 2020
dc.date.none.fl_str_mv 2020
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://www.mdpi.com/2309-608X/6/4/374
https://hdl.handle.net/10578/46958
url https://www.mdpi.com/2309-608X/6/4/374
https://hdl.handle.net/10578/46958
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv SAF2017-86188-P
GIC15/78 IT-990-16
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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