Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Ve...

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Detalhes bibliográficos
Autores: Reiner, Agnes T., Witwer, Kenneth W., Balkom, Bas W. M. van, Beer, Joel de, Brodie, Chaya, Corteling, Randolph L., Gabrielsson, Susanne, Gimona, Mario, Ibrahim, Ahmed G., Kleijn, Dominique de, Lai, Charles P., Lötvall, Jan, Portillo Obando, Hernando A. del, Reischl, Ilona G., Riazifar, Milad, Salomon, Carlos, Tahara, Hidetoshi, Toh, Wei Seong, Wauben, Marca H. M., Yang, Vicky K., Yang, Yijun, Yeo, Ronnie Wee Yeh, Yin, Hang, Giebel, Bernd, Rohde, Eva, Lim, Sai Kiang
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2017
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/114202
Acesso em linha:https://hdl.handle.net/2445/114202
Access Level:Acceso aberto
Palavra-chave:Espai extracel·lular
Ús terapèutic
Membranes cel·lulars
Extracellular space
Therapeutic use
Cell membranes
Descrição
Resumo:Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of best-practice models for EV therapies. Stem Cells Translational Medicine 2017.

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