Time dependent changes of klotho and FGF-23 levels after kidney transplantation: role of cold ischemia time, renal function and graft inflammation

We investigated the evolution of serum klotho (s-Kl) and FGF-23 during the first two years post-kidney transplantation (KT), considering the cold ischemia time (CIT), glomerular filtration rate (GFR) and graft subclinical inflammation (SCI). We undertook a prospective, cohort, multicenter study of c...

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Autores: Hernández Marrero, Domingo Jerónimo, Vázquez Sánchez, Teresa, Sánchez Niño, María Dolores, Ruíz Esteban, Pedro, López, Verónica, León, Myriam, Caballero, Abelardo, Ruíz Escalera, Juan Francisco, Ortiz, Alberto, Torres, Armando, Rodríguez, Mariano
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de La Laguna (ULL)
Repositorio:RIULL. Repositorio Institucional de la Universidad de La Laguna
OAI Identifier:oai:riull.ull.es:915/40238
Acceso en línea:http://riull.ull.es/xmlui/handle/915/40238
Access Level:acceso abierto
Palabra clave:kidney transplant
serum klotho levels
serum FGF-23 levels
graft function
graft subclinical inflammation
cold ischemia time
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spelling Time dependent changes of klotho and FGF-23 levels after kidney transplantation: role of cold ischemia time, renal function and graft inflammationHernández Marrero, Domingo JerónimoVázquez Sánchez, TeresaSánchez Niño, María DoloresRuíz Esteban, PedroLópez, VerónicaLeón, MyriamCaballero, AbelardoRuíz Escalera, Juan FranciscoOrtiz, AlbertoTorres, ArmandoRodríguez, Marianokidney transplantserum klotho levelsserum FGF-23 levelsgraft functiongraft subclinical inflammationcold ischemia timeWe investigated the evolution of serum klotho (s-Kl) and FGF-23 during the first two years post-kidney transplantation (KT), considering the cold ischemia time (CIT), glomerular filtration rate (GFR) and graft subclinical inflammation (SCI). We undertook a prospective, cohort, multicenter study of consecutive patients between April 2018 and January 2021 (with follow-up at 24 months). Subgroups were analyzed according to the median CIT (<14 vs. ≥14 h), the median GFR (≤40 vs. >40 mL/min/1.73 m2) and the presence of SCI at month 3. A total of 147 patients were included. s-Kl and fibroblast growth factor-23 (FGF-23) levels were measured at baseline and at months 3, 12 and 24. Graft biopsies (n = 96) were performed at month 3. All patients had low s-Kl levels at month 3. Patients with CIT < 14 h exhibited a significant increase in s-Kl at month 24. In patients with CIT ≥ 14 h, s-Kl at month 3 fell and lower s-Kl levels were seen at month 24. Patients with a GFR > 40 had a lesser decrease in s-Kl at month 3. FGF-23 fell significantly at months 3 and 12 in both GFR groups, a reduction maintained during follow-up. There were significant inter-group differences in s-Kl from months 3 to 24. CIT, GFR at 3 months and SCI were significantly associated with s-KI at month 3. A reduction in s-Kl at month 3 post-KT could be explained by longer CIT and delayed graft function as well as by impaired graft function. Early SCI may regulate s-Kl increase post-KT.Medicina Interna, Dermatología y Psiquiatría202420242023info:eu-repo/semantics/articleapplication/pdfhttp://riull.ull.es/xmlui/handle/915/40238reponame:RIULL. Repositorio Institucional de la Universidad de La Lagunainstname:Universidad de La Laguna (ULL)InglésJournal of Clinical Medicine 2023, 12, 4486Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ESoai:riull.ull.es:915/402382026-06-22T13:13:57Z
dc.title.none.fl_str_mv Time dependent changes of klotho and FGF-23 levels after kidney transplantation: role of cold ischemia time, renal function and graft inflammation
title Time dependent changes of klotho and FGF-23 levels after kidney transplantation: role of cold ischemia time, renal function and graft inflammation
spellingShingle Time dependent changes of klotho and FGF-23 levels after kidney transplantation: role of cold ischemia time, renal function and graft inflammation
Hernández Marrero, Domingo Jerónimo
kidney transplant
serum klotho levels
serum FGF-23 levels
graft function
graft subclinical inflammation
cold ischemia time
title_short Time dependent changes of klotho and FGF-23 levels after kidney transplantation: role of cold ischemia time, renal function and graft inflammation
title_full Time dependent changes of klotho and FGF-23 levels after kidney transplantation: role of cold ischemia time, renal function and graft inflammation
title_fullStr Time dependent changes of klotho and FGF-23 levels after kidney transplantation: role of cold ischemia time, renal function and graft inflammation
title_full_unstemmed Time dependent changes of klotho and FGF-23 levels after kidney transplantation: role of cold ischemia time, renal function and graft inflammation
title_sort Time dependent changes of klotho and FGF-23 levels after kidney transplantation: role of cold ischemia time, renal function and graft inflammation
dc.creator.none.fl_str_mv Hernández Marrero, Domingo Jerónimo
Vázquez Sánchez, Teresa
Sánchez Niño, María Dolores
Ruíz Esteban, Pedro
López, Verónica
León, Myriam
Caballero, Abelardo
Ruíz Escalera, Juan Francisco
Ortiz, Alberto
Torres, Armando
Rodríguez, Mariano
author Hernández Marrero, Domingo Jerónimo
author_facet Hernández Marrero, Domingo Jerónimo
Vázquez Sánchez, Teresa
Sánchez Niño, María Dolores
Ruíz Esteban, Pedro
López, Verónica
León, Myriam
Caballero, Abelardo
Ruíz Escalera, Juan Francisco
Ortiz, Alberto
Torres, Armando
Rodríguez, Mariano
author_role author
author2 Vázquez Sánchez, Teresa
Sánchez Niño, María Dolores
Ruíz Esteban, Pedro
López, Verónica
León, Myriam
Caballero, Abelardo
Ruíz Escalera, Juan Francisco
Ortiz, Alberto
Torres, Armando
Rodríguez, Mariano
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Medicina Interna, Dermatología y Psiquiatría
dc.subject.none.fl_str_mv kidney transplant
serum klotho levels
serum FGF-23 levels
graft function
graft subclinical inflammation
cold ischemia time
topic kidney transplant
serum klotho levels
serum FGF-23 levels
graft function
graft subclinical inflammation
cold ischemia time
description We investigated the evolution of serum klotho (s-Kl) and FGF-23 during the first two years post-kidney transplantation (KT), considering the cold ischemia time (CIT), glomerular filtration rate (GFR) and graft subclinical inflammation (SCI). We undertook a prospective, cohort, multicenter study of consecutive patients between April 2018 and January 2021 (with follow-up at 24 months). Subgroups were analyzed according to the median CIT (<14 vs. ≥14 h), the median GFR (≤40 vs. >40 mL/min/1.73 m2) and the presence of SCI at month 3. A total of 147 patients were included. s-Kl and fibroblast growth factor-23 (FGF-23) levels were measured at baseline and at months 3, 12 and 24. Graft biopsies (n = 96) were performed at month 3. All patients had low s-Kl levels at month 3. Patients with CIT < 14 h exhibited a significant increase in s-Kl at month 24. In patients with CIT ≥ 14 h, s-Kl at month 3 fell and lower s-Kl levels were seen at month 24. Patients with a GFR > 40 had a lesser decrease in s-Kl at month 3. FGF-23 fell significantly at months 3 and 12 in both GFR groups, a reduction maintained during follow-up. There were significant inter-group differences in s-Kl from months 3 to 24. CIT, GFR at 3 months and SCI were significantly associated with s-KI at month 3. A reduction in s-Kl at month 3 post-KT could be explained by longer CIT and delayed graft function as well as by impaired graft function. Early SCI may regulate s-Kl increase post-KT.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://riull.ull.es/xmlui/handle/915/40238
url http://riull.ull.es/xmlui/handle/915/40238
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical Medicine 2023, 12, 4486
dc.rights.none.fl_str_mv Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
rights_invalid_str_mv Licencia Creative Commons (Reconocimiento-No comercial-Sin obras derivadas 4.0 Internacional)
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es_ES
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIULL. Repositorio Institucional de la Universidad de La Laguna
instname:Universidad de La Laguna (ULL)
instname_str Universidad de La Laguna (ULL)
reponame_str RIULL. Repositorio Institucional de la Universidad de La Laguna
collection RIULL. Repositorio Institucional de la Universidad de La Laguna
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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