High Rates of Non-Tuberculous Mycobacteria Isolation in Mozambican Children with Presumptive Tuberculosis

INTRODUCTION: Non-tuberculous mycobacteria (NTM) can cause disease which can be clinically and radiologically undistinguishable from tuberculosis (TB), posing a diagnostic and therapeutic challenge in high TB settings. We aim to describe the prevalence of NTM isolation and its clinical characteristi...

Descripción completa

Detalles Bibliográficos
Autores: López Varela, Elisa, García-Basteiro, Alberto L., Augusto, Orvalho, Fraile, Oscar, Bulo, Helder, Ira, Tasmiya, Gondo, Kizito, Ingen, Jakko van, Naniche, Denise, Sacarlal, Jahit, Alonso, Pedro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/106471
Acceso en línea:https://hdl.handle.net/2445/106471
Access Level:acceso abierto
Palabra clave:Tuberculosi
Infants
Moçambic
Tuberculosis
Children
Mozambique
id ES_2bc8aebfded2741072bb4ea6c824be60
oai_identifier_str oai:recercat.cat:2445/106471
network_acronym_str ES
network_name_str España
repository_id_str
spelling High Rates of Non-Tuberculous Mycobacteria Isolation in Mozambican Children with Presumptive TuberculosisLópez Varela, ElisaGarcía-Basteiro, Alberto L.Augusto, OrvalhoFraile, OscarBulo, HelderIra, TasmiyaGondo, KizitoIngen, Jakko vanNaniche, DeniseSacarlal, JahitAlonso, PedroTuberculosiInfantsMoçambicTuberculosisChildrenMozambiqueINTRODUCTION: Non-tuberculous mycobacteria (NTM) can cause disease which can be clinically and radiologically undistinguishable from tuberculosis (TB), posing a diagnostic and therapeutic challenge in high TB settings. We aim to describe the prevalence of NTM isolation and its clinical characteristics in children from rural Mozambique. METHODS: This study was part of a community TB incidence study in children <3 years of age. Gastric aspirate and induced sputum sampling were performed in all presumptive TB cases and processed for smear testing using fluorochrome staining and LED Microscopy, liquid and solid culture, and molecular identification by GenoType(R) Mycobacterium CM/AS assays. RESULTS: NTM were isolated in 26.3% (204/775) of children. The most prevalent NTM species was M. intracellulare (N = 128), followed by M. scrofulaceum (N = 35) and M. fortuitum (N = 9). Children with NTM were significantly less symptomatic and less likely to present with an abnormal chest radiograph than those with M. tuberculosis. NTM were present in 21.6% of follow-up samples and 25 children had the same species isolated from >/=2 separate samples. All were considered clinically insignificant and none received specific treatment. Children with NTM isolates had equal all cause mortality and likelihood of TB treatment as those with negative culture although they were less likely to have TB ruled out. CONCLUSIONS: NTM isolation is frequent in presumptive TB cases but was not clinically significant in this patient cohort. However, it can contribute to TB misdiagnosis. Further studies are needed to understand the epidemiology and the clinical significance of NTM in children.Public Library of Science (PLoS)2017201720172017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/106471Articles publicats en revistes (ISGlobal)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0169757PLoS One, 2017, vol. 12, num. 1, p. e0169757http://dx.doi.org/10.1371/journal.pone.0169757cc by (c) López Varela et al., 2017http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1064712026-05-29T05:05:01Z
dc.title.none.fl_str_mv High Rates of Non-Tuberculous Mycobacteria Isolation in Mozambican Children with Presumptive Tuberculosis
title High Rates of Non-Tuberculous Mycobacteria Isolation in Mozambican Children with Presumptive Tuberculosis
spellingShingle High Rates of Non-Tuberculous Mycobacteria Isolation in Mozambican Children with Presumptive Tuberculosis
López Varela, Elisa
Tuberculosi
Infants
Moçambic
Tuberculosis
Children
Mozambique
title_short High Rates of Non-Tuberculous Mycobacteria Isolation in Mozambican Children with Presumptive Tuberculosis
title_full High Rates of Non-Tuberculous Mycobacteria Isolation in Mozambican Children with Presumptive Tuberculosis
title_fullStr High Rates of Non-Tuberculous Mycobacteria Isolation in Mozambican Children with Presumptive Tuberculosis
title_full_unstemmed High Rates of Non-Tuberculous Mycobacteria Isolation in Mozambican Children with Presumptive Tuberculosis
title_sort High Rates of Non-Tuberculous Mycobacteria Isolation in Mozambican Children with Presumptive Tuberculosis
dc.creator.none.fl_str_mv López Varela, Elisa
García-Basteiro, Alberto L.
Augusto, Orvalho
Fraile, Oscar
Bulo, Helder
Ira, Tasmiya
Gondo, Kizito
Ingen, Jakko van
Naniche, Denise
Sacarlal, Jahit
Alonso, Pedro
author López Varela, Elisa
author_facet López Varela, Elisa
García-Basteiro, Alberto L.
Augusto, Orvalho
Fraile, Oscar
Bulo, Helder
Ira, Tasmiya
Gondo, Kizito
Ingen, Jakko van
Naniche, Denise
Sacarlal, Jahit
Alonso, Pedro
author_role author
author2 García-Basteiro, Alberto L.
Augusto, Orvalho
Fraile, Oscar
Bulo, Helder
Ira, Tasmiya
Gondo, Kizito
Ingen, Jakko van
Naniche, Denise
Sacarlal, Jahit
Alonso, Pedro
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Tuberculosi
Infants
Moçambic
Tuberculosis
Children
Mozambique
topic Tuberculosi
Infants
Moçambic
Tuberculosis
Children
Mozambique
description INTRODUCTION: Non-tuberculous mycobacteria (NTM) can cause disease which can be clinically and radiologically undistinguishable from tuberculosis (TB), posing a diagnostic and therapeutic challenge in high TB settings. We aim to describe the prevalence of NTM isolation and its clinical characteristics in children from rural Mozambique. METHODS: This study was part of a community TB incidence study in children <3 years of age. Gastric aspirate and induced sputum sampling were performed in all presumptive TB cases and processed for smear testing using fluorochrome staining and LED Microscopy, liquid and solid culture, and molecular identification by GenoType(R) Mycobacterium CM/AS assays. RESULTS: NTM were isolated in 26.3% (204/775) of children. The most prevalent NTM species was M. intracellulare (N = 128), followed by M. scrofulaceum (N = 35) and M. fortuitum (N = 9). Children with NTM were significantly less symptomatic and less likely to present with an abnormal chest radiograph than those with M. tuberculosis. NTM were present in 21.6% of follow-up samples and 25 children had the same species isolated from >/=2 separate samples. All were considered clinically insignificant and none received specific treatment. Children with NTM isolates had equal all cause mortality and likelihood of TB treatment as those with negative culture although they were less likely to have TB ruled out. CONCLUSIONS: NTM isolation is frequent in presumptive TB cases but was not clinically significant in this patient cohort. However, it can contribute to TB misdiagnosis. Further studies are needed to understand the epidemiology and the clinical significance of NTM in children.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/106471
url https://hdl.handle.net/2445/106471
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0169757
PLoS One, 2017, vol. 12, num. 1, p. e0169757
http://dx.doi.org/10.1371/journal.pone.0169757
dc.rights.none.fl_str_mv cc by (c) López Varela et al., 2017
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) López Varela et al., 2017
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405180293808128
score 15,81155

Similares en LA Referencia