DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium

Two square-planar coordination compounds, namely [Cu(CPYA)Cl2] (1) and [Pd(CPYA)Cl2] (2), were prepared from the ligand 4-chloro-N-(pyridin-2-ylmethyl)aniline (CPYA) and two chloride salts, and were fully characterized, including by X-ray diffraction. Spectroscopic, electrophoretic and AFM studies r...

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Autores: Palmeira-Mello, Marcos V., Caballero Hernández, Ana Belén, López Espinar, Aida, Guedes, Guilherme P., Caubet Marín, Amparo, Teles de Souza, Alessandra M., Lanznaster, Mauricio, Gámez Enamorado, Patrick
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/185183
Acceso en línea:https://hdl.handle.net/2445/185183
Access Level:acceso abierto
Palabra clave:ADN
Cisplatí
Pal·ladi (Element químic)
DNA
Cisplatin
Palladium
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repository_id_str
spelling DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladiumPalmeira-Mello, Marcos V.Caballero Hernández, Ana BelénLópez Espinar, AidaGuedes, Guilherme P.Caubet Marín, AmparoTeles de Souza, Alessandra M.Lanznaster, MauricioGámez Enamorado, PatrickADNCisplatíPal·ladi (Element químic)DNACisplatinPalladiumTwo square-planar coordination compounds, namely [Cu(CPYA)Cl2] (1) and [Pd(CPYA)Cl2] (2), were prepared from the ligand 4-chloro-N-(pyridin-2-ylmethyl)aniline (CPYA) and two chloride salts, and were fully characterized, including by X-ray diffraction. Spectroscopic, electrophoretic and AFM studies revealed that the two isostructural compounds were interacting differently with DNA. In both cases, the initial interaction involves electrostatic contacts of the CPYA ligand in the minor groove (as suggested by molecular docking), but subsequent strong binding occurs with the palladium(II) complex 2, whereas the binding with the copper complex 1 is weaker and concentration dependent. The strong binding of 2 eventually leads to the cleavage of the double strand and the redox activity of 1 allows to oxidatively cleave the biomolecule.Springer Verlag2022202220212022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/185183Articles publicats en revistes (Química Inorgànica i Orgànica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1007/s00775-021-01888-2Journal of Biological Inorganic Chemistry, 2021, vol. 26, num. 6, p. 727-740https://doi.org/10.1007/s00775-021-01888-2cc-by (c) Palmeira-Mello, Marcos V., et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1851832026-05-29T05:05:01Z
dc.title.none.fl_str_mv DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium
title DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium
spellingShingle DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium
Palmeira-Mello, Marcos V.
ADN
Cisplatí
Pal·ladi (Element químic)
DNA
Cisplatin
Palladium
title_short DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium
title_full DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium
title_fullStr DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium
title_full_unstemmed DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium
title_sort DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium
dc.creator.none.fl_str_mv Palmeira-Mello, Marcos V.
Caballero Hernández, Ana Belén
López Espinar, Aida
Guedes, Guilherme P.
Caubet Marín, Amparo
Teles de Souza, Alessandra M.
Lanznaster, Mauricio
Gámez Enamorado, Patrick
author Palmeira-Mello, Marcos V.
author_facet Palmeira-Mello, Marcos V.
Caballero Hernández, Ana Belén
López Espinar, Aida
Guedes, Guilherme P.
Caubet Marín, Amparo
Teles de Souza, Alessandra M.
Lanznaster, Mauricio
Gámez Enamorado, Patrick
author_role author
author2 Caballero Hernández, Ana Belén
López Espinar, Aida
Guedes, Guilherme P.
Caubet Marín, Amparo
Teles de Souza, Alessandra M.
Lanznaster, Mauricio
Gámez Enamorado, Patrick
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ADN
Cisplatí
Pal·ladi (Element químic)
DNA
Cisplatin
Palladium
topic ADN
Cisplatí
Pal·ladi (Element químic)
DNA
Cisplatin
Palladium
description Two square-planar coordination compounds, namely [Cu(CPYA)Cl2] (1) and [Pd(CPYA)Cl2] (2), were prepared from the ligand 4-chloro-N-(pyridin-2-ylmethyl)aniline (CPYA) and two chloride salts, and were fully characterized, including by X-ray diffraction. Spectroscopic, electrophoretic and AFM studies revealed that the two isostructural compounds were interacting differently with DNA. In both cases, the initial interaction involves electrostatic contacts of the CPYA ligand in the minor groove (as suggested by molecular docking), but subsequent strong binding occurs with the palladium(II) complex 2, whereas the binding with the copper complex 1 is weaker and concentration dependent. The strong binding of 2 eventually leads to the cleavage of the double strand and the redox activity of 1 allows to oxidatively cleave the biomolecule.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/185183
url https://hdl.handle.net/2445/185183
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1007/s00775-021-01888-2
Journal of Biological Inorganic Chemistry, 2021, vol. 26, num. 6, p. 727-740
https://doi.org/10.1007/s00775-021-01888-2
dc.rights.none.fl_str_mv cc-by (c) Palmeira-Mello, Marcos V., et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Palmeira-Mello, Marcos V., et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Química Inorgànica i Orgànica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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