Cognitive outcomes following functional neurosurgery in refractory OCD patients: a systematic review

Neurosurgery is a therapeutic option for patients with refractory obsessive-compulsive disorder who do not respond to previous treatments. Although its efficacy in reducing clinical symptomatology has been proven, few studies have analyzed its effects at the cognitive level. The aim of this systemat...

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Autores: Laseca Zaballa, Garazi, Lubrini, Genny, Periáñez Morales, José Antonio, Simón Martínez, V., Martín Bejarano, M., Torres Díaz, C., Martínez Moreno, N., Álvarez Linera, J., Martínez Álvarez, R., Ríos Lago, M.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/124786
Acceso en línea:https://hdl.handle.net/20.500.14352/124786
Access Level:acceso abierto
Palabra clave:Capsulotomy
Cingulotomy
Cognition
Neuropsychology
Neurosurgery
Obsessive–compulsive disorder
Cirugía
3213.08 Neurocirugía
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spelling Cognitive outcomes following functional neurosurgery in refractory OCD patients: a systematic reviewLaseca Zaballa, GaraziLubrini, GennyPeriáñez Morales, José AntonioSimón Martínez, V.Martín Bejarano, M.Torres Díaz, C.Martínez Moreno, N.Álvarez Linera, J.Martínez Álvarez, R.Ríos Lago, M.CapsulotomyCingulotomyCognitionNeuropsychologyNeurosurgeryObsessive–compulsive disorderCirugía3213.08 NeurocirugíaNeurosurgery is a therapeutic option for patients with refractory obsessive-compulsive disorder who do not respond to previous treatments. Although its efficacy in reducing clinical symptomatology has been proven, few studies have analyzed its effects at the cognitive level. The aim of this systematic review was to describe the cognitive outcomes of functional neurosurgery in patients that went through capsulotomies or cingulotomies. PubMed, Medline, Scopus, PsycInfo, PsyArticles, and Web of Knowledge were searched for studies reporting cognitive outcomes in refractory obsessive-compulsive patients after capsulotomies and cingulotomies. The risk of bias was assessed with the Assessment Tool for Before-After (Pre-Post) Studies With No Control Group tool; 13 studies met inclusion criteria, including 205 refractory obsessive-compulsive disorder patients for both surgical procedures. Results showed a substantial number of studies that did report significant cognitive improvement after surgery, being this improvement specially related to memory and executive functions. The second-most frequent finding is the maintenance of cognitive performance (nor improvement or worsening). From a neuropsychological point of view, this outcome might be considered a success, given that it is accompanied by amelioration of obsessive-compulsive symptoms. Subtle cognitive adverse effects have also been reported. Neurosurgery procedures appear to be safe from a cognitive point of view. Methodological issues must be improved to draw clearer conclusions, but capsulotomies and cingulotomies constitute an effective alternative treatment for refractory obsessive-compulsive disorder patients.SpringerUniversidad Complutense de Madrid20232023-06-2320232023-06-23journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/124786reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1247862026-06-02T12:44:21Z
dc.title.none.fl_str_mv Cognitive outcomes following functional neurosurgery in refractory OCD patients: a systematic review
title Cognitive outcomes following functional neurosurgery in refractory OCD patients: a systematic review
spellingShingle Cognitive outcomes following functional neurosurgery in refractory OCD patients: a systematic review
Laseca Zaballa, Garazi
Capsulotomy
Cingulotomy
Cognition
Neuropsychology
Neurosurgery
Obsessive–compulsive disorder
Cirugía
3213.08 Neurocirugía
title_short Cognitive outcomes following functional neurosurgery in refractory OCD patients: a systematic review
title_full Cognitive outcomes following functional neurosurgery in refractory OCD patients: a systematic review
title_fullStr Cognitive outcomes following functional neurosurgery in refractory OCD patients: a systematic review
title_full_unstemmed Cognitive outcomes following functional neurosurgery in refractory OCD patients: a systematic review
title_sort Cognitive outcomes following functional neurosurgery in refractory OCD patients: a systematic review
dc.creator.none.fl_str_mv Laseca Zaballa, Garazi
Lubrini, Genny
Periáñez Morales, José Antonio
Simón Martínez, V.
Martín Bejarano, M.
Torres Díaz, C.
Martínez Moreno, N.
Álvarez Linera, J.
Martínez Álvarez, R.
Ríos Lago, M.
author Laseca Zaballa, Garazi
author_facet Laseca Zaballa, Garazi
Lubrini, Genny
Periáñez Morales, José Antonio
Simón Martínez, V.
Martín Bejarano, M.
Torres Díaz, C.
Martínez Moreno, N.
Álvarez Linera, J.
Martínez Álvarez, R.
Ríos Lago, M.
author_role author
author2 Lubrini, Genny
Periáñez Morales, José Antonio
Simón Martínez, V.
Martín Bejarano, M.
Torres Díaz, C.
Martínez Moreno, N.
Álvarez Linera, J.
Martínez Álvarez, R.
Ríos Lago, M.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Capsulotomy
Cingulotomy
Cognition
Neuropsychology
Neurosurgery
Obsessive–compulsive disorder
Cirugía
3213.08 Neurocirugía
topic Capsulotomy
Cingulotomy
Cognition
Neuropsychology
Neurosurgery
Obsessive–compulsive disorder
Cirugía
3213.08 Neurocirugía
description Neurosurgery is a therapeutic option for patients with refractory obsessive-compulsive disorder who do not respond to previous treatments. Although its efficacy in reducing clinical symptomatology has been proven, few studies have analyzed its effects at the cognitive level. The aim of this systematic review was to describe the cognitive outcomes of functional neurosurgery in patients that went through capsulotomies or cingulotomies. PubMed, Medline, Scopus, PsycInfo, PsyArticles, and Web of Knowledge were searched for studies reporting cognitive outcomes in refractory obsessive-compulsive patients after capsulotomies and cingulotomies. The risk of bias was assessed with the Assessment Tool for Before-After (Pre-Post) Studies With No Control Group tool; 13 studies met inclusion criteria, including 205 refractory obsessive-compulsive disorder patients for both surgical procedures. Results showed a substantial number of studies that did report significant cognitive improvement after surgery, being this improvement specially related to memory and executive functions. The second-most frequent finding is the maintenance of cognitive performance (nor improvement or worsening). From a neuropsychological point of view, this outcome might be considered a success, given that it is accompanied by amelioration of obsessive-compulsive symptoms. Subtle cognitive adverse effects have also been reported. Neurosurgery procedures appear to be safe from a cognitive point of view. Methodological issues must be improved to draw clearer conclusions, but capsulotomies and cingulotomies constitute an effective alternative treatment for refractory obsessive-compulsive disorder patients.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-06-23
2023
2023-06-23
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/124786
url https://hdl.handle.net/20.500.14352/124786
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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