Emerging concepts in liver graft preservation

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon thi...

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Authors: Bejaoui, Mohamed, Pantazi, Eirini, Folch-Puy, Emma, Baptista, Pedro M., García-Gil, Agustín, Adam, René, Roselló-Catafau, Joan
Format: article
Status:Published version
Publication Date:2015
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/114007
Online Access:http://hdl.handle.net/10261/114007
Access Level:Open access
Keyword:Static cold preservation
Suboptimal liver grafts
Preservation solutions
Graft washout solutions
Machine perfusion and liver bioengineering
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spelling Emerging concepts in liver graft preservationBejaoui, MohamedPantazi, EiriniFolch-Puy, EmmaBaptista, Pedro M.García-Gil, AgustínAdam, RenéRoselló-Catafau, JoanStatic cold preservationSuboptimal liver graftsPreservation solutionsGraft washout solutionsMachine perfusion and liver bioengineeringThis article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.The urgent need to expand the donor pool in order to attend to the growing demand for liver transplantation has obliged physicians to consider the use of suboptimal liver grafts and also to redefine the preservation strategies. This review examines the different methods of liver graft preservation, focusing on the latest advances in both static cold storage and machine perfusion (MP). The new strategies for static cold storage are mainly designed to increase the fatty liver graft preservation via the supplementation of commercial organ preservation solutions with additives. In this paper we stress the importance of carrying out effective graft washout after static cold preservation, and present a detailed discussion of the future perspectives for dynamic graft preservation using MP at different temperatures (hypothermia at 4 °C, normothermia at 37 °C and subnormothermia at 20 °C-25 °C). Finally, we highlight some emerging applications of regenerative medicine in liver graft preservation. In conclusion, this review discusses the “state of the art” and future perspectives in static and dynamic liver graft preservation in order to improve graft viability.Supported by Grant from Fondo de Investigaciones Sanitarias, No. FIS PI12/00519; Eirini Pantazi is the recipient of a fellowship from Agència de Gestió d’Ajuts Universitaris i de Recerca, No. 2012FI_B00382, Generalitat de Catalunya, Barcelona, Spain.Fondo de Investigación Sanitaria (España)Generalidad de CataluñaPeer reviewedBaishideng Publishing GroupConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201520152015info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/114007reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3748/wjg.v21.i2.396Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1140072026-05-22T06:33:51Z
dc.title.none.fl_str_mv Emerging concepts in liver graft preservation
title Emerging concepts in liver graft preservation
spellingShingle Emerging concepts in liver graft preservation
Bejaoui, Mohamed
Static cold preservation
Suboptimal liver grafts
Preservation solutions
Graft washout solutions
Machine perfusion and liver bioengineering
title_short Emerging concepts in liver graft preservation
title_full Emerging concepts in liver graft preservation
title_fullStr Emerging concepts in liver graft preservation
title_full_unstemmed Emerging concepts in liver graft preservation
title_sort Emerging concepts in liver graft preservation
dc.creator.none.fl_str_mv Bejaoui, Mohamed
Pantazi, Eirini
Folch-Puy, Emma
Baptista, Pedro M.
García-Gil, Agustín
Adam, René
Roselló-Catafau, Joan
author Bejaoui, Mohamed
author_facet Bejaoui, Mohamed
Pantazi, Eirini
Folch-Puy, Emma
Baptista, Pedro M.
García-Gil, Agustín
Adam, René
Roselló-Catafau, Joan
author_role author
author2 Pantazi, Eirini
Folch-Puy, Emma
Baptista, Pedro M.
García-Gil, Agustín
Adam, René
Roselló-Catafau, Joan
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Static cold preservation
Suboptimal liver grafts
Preservation solutions
Graft washout solutions
Machine perfusion and liver bioengineering
topic Static cold preservation
Suboptimal liver grafts
Preservation solutions
Graft washout solutions
Machine perfusion and liver bioengineering
description This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/114007
url http://hdl.handle.net/10261/114007
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3748/wjg.v21.i2.396
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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