Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1

Cell adhesion to the substratum and/or other cells is a crucial step of cell migration. While essential in the case of solitary migrating cells (for example, immune cells), it becomes particularly important in collective cell migration, in which cells maintain contact with their neighbors while movi...

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Detalles Bibliográficos
Autores: Aguilar-Cuenca, Rocío, Llorente-González, Clara, Vicente Córdoba, Carlos, Vicente Manzanares, M.
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/18466
Acceso en línea:https://hdl.handle.net/20.500.14352/18466
Access Level:acceso abierto
Palabra clave:576.3
Cell adhession
Cell migration
Tissues
Biología celular (Biología)
2407 Biología Celular
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oai_identifier_str oai:docta.ucm.es:20.500.14352/18466
network_acronym_str ES
network_name_str España
repository_id_str
spelling Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1Referees:4:approved]Aguilar-Cuenca, RocíoLlorente-González, ClaraVicente Córdoba, CarlosVicente Manzanares, M.576.3Cell adhessionCell migrationTissuesBiología celular (Biología)2407 Biología CelularCell adhesion to the substratum and/or other cells is a crucial step of cell migration. While essential in the case of solitary migrating cells (for example, immune cells), it becomes particularly important in collective cell migration, in which cells maintain contact with their neighbors while moving directionally. Adhesive coordination is paramount in physiological contexts (for example, during organogenesis) but also in pathology (for example, tumor metastasis). In this review, we address the need for a coordinated regulation of cell-cell and cell-matrix adhesions during collective cell migration. We emphasize the role of the actin cytoskeleton as an intracellular integrator of cadherin- and integrin-based adhesions and the emerging role of mechanics in the maintenance, reinforcement, and turnover of adhesive contacts. Recent advances in understanding the mechanical regulation of several components of cadherin and integrin adhesions allow us to revisit the adhesive clutch hypothesis that controls the degree of adhesive engagement during protrusion. Finally, we provide a brief overview of the major impact of these discoveries when using more physiological three-dimensional models of single and collective cell migration.F1000ResearchUniversidad Complutense de Madrid20172017-02-1720172017-02-17journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/18466reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/184662026-06-02T12:44:21Z
dc.title.none.fl_str_mv Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1
Referees:4:approved]
title Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1
spellingShingle Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1
Aguilar-Cuenca, Rocío
576.3
Cell adhession
Cell migration
Tissues
Biología celular (Biología)
2407 Biología Celular
title_short Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1
title_full Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1
title_fullStr Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1
title_full_unstemmed Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1
title_sort Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues [version 1
dc.creator.none.fl_str_mv Aguilar-Cuenca, Rocío
Llorente-González, Clara
Vicente Córdoba, Carlos
Vicente Manzanares, M.
author Aguilar-Cuenca, Rocío
author_facet Aguilar-Cuenca, Rocío
Llorente-González, Clara
Vicente Córdoba, Carlos
Vicente Manzanares, M.
author_role author
author2 Llorente-González, Clara
Vicente Córdoba, Carlos
Vicente Manzanares, M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 576.3
Cell adhession
Cell migration
Tissues
Biología celular (Biología)
2407 Biología Celular
topic 576.3
Cell adhession
Cell migration
Tissues
Biología celular (Biología)
2407 Biología Celular
description Cell adhesion to the substratum and/or other cells is a crucial step of cell migration. While essential in the case of solitary migrating cells (for example, immune cells), it becomes particularly important in collective cell migration, in which cells maintain contact with their neighbors while moving directionally. Adhesive coordination is paramount in physiological contexts (for example, during organogenesis) but also in pathology (for example, tumor metastasis). In this review, we address the need for a coordinated regulation of cell-cell and cell-matrix adhesions during collective cell migration. We emphasize the role of the actin cytoskeleton as an intracellular integrator of cadherin- and integrin-based adhesions and the emerging role of mechanics in the maintenance, reinforcement, and turnover of adhesive contacts. Recent advances in understanding the mechanical regulation of several components of cadherin and integrin adhesions allow us to revisit the adhesive clutch hypothesis that controls the degree of adhesive engagement during protrusion. Finally, we provide a brief overview of the major impact of these discoveries when using more physiological three-dimensional models of single and collective cell migration.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-02-17
2017
2017-02-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/18466
url https://hdl.handle.net/20.500.14352/18466
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv F1000Research
publisher.none.fl_str_mv F1000Research
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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