Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?

Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the possible relationship between mitochondrial dysfunction, oxidative stress, an...

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Autores: Cordero, Mario D., Díaz-Parrado, Eduardo, Carrión, Ángel Manuel, Alfonsi, Simona, Sánchez Alcázar, José Antonio, Miguel Rodríguez, Manuel de, Battino, Maurizio
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2013
País:España
Recursos:Universidad de Sevilla (US)
Repositório:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/82046
Acesso em linha:https://hdl.handle.net/11441/82046
https://doi.org/10.1089/ars.2012.4892
Access Level:Acceso aberto
Palavra-chave:Fibromyalgia
mitochondrial dysfunction
inflammation
FM
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spelling Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?Cordero, Mario D.Díaz-Parrado, EduardoCarrión, Ángel ManuelAlfonsi, SimonaSánchez Alcázar, José AntonioMiguel Rodríguez, Manuel deBattino, MaurizioMiguel Rodríguez, Manuel deFibromyalgiamitochondrial dysfunctioninflammationFMFibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the possible relationship between mitochondrial dysfunction, oxidative stress, and inflammation in FM. We studied 30 women diagnosed with FM and 20 healthy women. Blood mononuclear cells (BMCs) from FM patients showed reduced level of coenzyme Q10 (CoQ10) and mtDNA contents and high level of mitochondrial reactive oxygen species (ROS) and serum tumor necrosis factor (TNF)-alpha and transcript levels. A significant negative correlation between CoQ10 and TNF-alpha levels (r= -0.588; p < 0.01), and a positive correlation between ROS and TNF-alpha levels (r = 0.791; p < 0.001) were observed accompanied by a significant correlation of visual analogical scale with serum TNF-alpha and transcript levels (r = 0.4507; p < 0.05 and r = 0.7089; p < 0.001, respectively). TNF-alpha release was observed in an in vitro (BMCs) and in vivo (mice) CoQ10 deficiency model. Oral CoQ10 supplementation restored biochemical parameters and induced a significant improvement in clinical symptoms ( p < 0.001). These results lead to the hypothesis that inflammation could be a mitochondrial dysfunction-dependent event implicated in the pathophysiology of FM in several patients indicating at mitochondria as a possible new therapeutic target.Unión Europea FIS PI10/00543Servicio Andaluz de Salud Junta de Andalucía SAS 111242Junta de Andalucía CTS-5725Mary Ann Liebert, Inc.EstomatologíaCTS 113: Investigacion Etiologia y Patogenia Periodontal, Patologia Oral y Enfermedades Musculares2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/82046https://doi.org/10.1089/ars.2012.4892reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésAntioxidants and redox signaling, 18 (7), 800-807.CTS113info:eu-repo/semantics/openAccessoai:idus.us.es:11441/820462026-06-17T12:51:07Z
dc.title.none.fl_str_mv Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
title Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
spellingShingle Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
Cordero, Mario D.
Fibromyalgia
mitochondrial dysfunction
inflammation
FM
title_short Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
title_full Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
title_fullStr Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
title_full_unstemmed Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
title_sort Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
dc.creator.none.fl_str_mv Cordero, Mario D.
Díaz-Parrado, Eduardo
Carrión, Ángel Manuel
Alfonsi, Simona
Sánchez Alcázar, José Antonio
Miguel Rodríguez, Manuel de
Battino, Maurizio
Miguel Rodríguez, Manuel de
author Cordero, Mario D.
author_facet Cordero, Mario D.
Díaz-Parrado, Eduardo
Carrión, Ángel Manuel
Alfonsi, Simona
Sánchez Alcázar, José Antonio
Miguel Rodríguez, Manuel de
Battino, Maurizio
author_role author
author2 Díaz-Parrado, Eduardo
Carrión, Ángel Manuel
Alfonsi, Simona
Sánchez Alcázar, José Antonio
Miguel Rodríguez, Manuel de
Battino, Maurizio
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Estomatología
CTS 113: Investigacion Etiologia y Patogenia Periodontal, Patologia Oral y Enfermedades Musculares
dc.subject.none.fl_str_mv Fibromyalgia
mitochondrial dysfunction
inflammation
FM
topic Fibromyalgia
mitochondrial dysfunction
inflammation
FM
description Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the possible relationship between mitochondrial dysfunction, oxidative stress, and inflammation in FM. We studied 30 women diagnosed with FM and 20 healthy women. Blood mononuclear cells (BMCs) from FM patients showed reduced level of coenzyme Q10 (CoQ10) and mtDNA contents and high level of mitochondrial reactive oxygen species (ROS) and serum tumor necrosis factor (TNF)-alpha and transcript levels. A significant negative correlation between CoQ10 and TNF-alpha levels (r= -0.588; p < 0.01), and a positive correlation between ROS and TNF-alpha levels (r = 0.791; p < 0.001) were observed accompanied by a significant correlation of visual analogical scale with serum TNF-alpha and transcript levels (r = 0.4507; p < 0.05 and r = 0.7089; p < 0.001, respectively). TNF-alpha release was observed in an in vitro (BMCs) and in vivo (mice) CoQ10 deficiency model. Oral CoQ10 supplementation restored biochemical parameters and induced a significant improvement in clinical symptoms ( p < 0.001). These results lead to the hypothesis that inflammation could be a mitochondrial dysfunction-dependent event implicated in the pathophysiology of FM in several patients indicating at mitochondria as a possible new therapeutic target.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/82046
https://doi.org/10.1089/ars.2012.4892
url https://hdl.handle.net/11441/82046
https://doi.org/10.1089/ars.2012.4892
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Antioxidants and redox signaling, 18 (7), 800-807.
CTS113
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert, Inc.
publisher.none.fl_str_mv Mary Ann Liebert, Inc.
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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