Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats
At birth, when immune responses are insufficient, there begins the development of the defence capability against pathogens. Leptin and adiponectin, adipokines that are present in breast milk, have been shown to play a role in the regulation of immune responses. We report here, for the first time, th...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/166221 |
| Acceso en línea: | https://hdl.handle.net/2445/166221 |
| Access Level: | acceso abierto |
| Palabra clave: | Farmacologia Immunologia Suplements nutritius Llet materna Rates (Animals de laboratori) Pharmacology Immunology Dietary supplements Breast milk Rats as laboratory animals |
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Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling ratsGrases Pintó, BlancaAbril Gil, Maria del MarRodríguez Lagunas, María JoséCastell, MargaridaPérez-Cano, Francisco J.Franch i Masferrer, ÀngelsFarmacologiaImmunologiaSuplements nutritiusLlet maternaRates (Animals de laboratori)PharmacologyImmunologyDietary supplementsBreast milkRats as laboratory animalsAt birth, when immune responses are insufficient, there begins the development of the defence capability against pathogens. Leptin and adiponectin, adipokines that are present in breast milk, have been shown to play a role in the regulation of immune responses. We report here, for the first time, the influence of in vivo adipokine supplementation on the intestinal immune system in early life. Suckling Wistar rats were daily supplemented with leptin (0·7 μg/kg per d, n 36) or adiponectin (35 μg/kg per d, n 36) during the suckling period. The lymphocyte composition,proliferation and cytokine secretion from mesenteric lymph node lymphocytes (on days 14 and 21), as well as intestinal IgA and IgM concentration (day 21), were evaluated. At day 14, leptin supplementation significantly increased the TCRαβ+ cell proportion in mesenteric lymph nodes, in particular owing to an increase in the TCRαβ+ CD8+ cell population. Moreover, the leptin or adiponectin supplementation promoted the early development CD8+ cells, with adiponectin being the only adipokine capable of enhancing the lymphoproliferative ability at the end of the suckling period. Although leptin decreased intestinal IgA concentration, it had a trophic effect on the intestine in early life. Supplementation of both adipokines modulated the cytokine profile during (day 14) and at the end (day 21) of the suckling period. These results suggest that leptin and adiponectin during suckling play a role in the development of mucosal immunity in early life.Cambridge University Press2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/166221Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1017/S0007114517003786British Journal of Nutrition, 2018, vol. 119, num. 5, p. 486-495https://doi.org/10.1017/S0007114517003786(c) Cambridge University Press, 2018info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1662212026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats |
| title |
Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats |
| spellingShingle |
Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats Grases Pintó, Blanca Farmacologia Immunologia Suplements nutritius Llet materna Rates (Animals de laboratori) Pharmacology Immunology Dietary supplements Breast milk Rats as laboratory animals |
| title_short |
Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats |
| title_full |
Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats |
| title_fullStr |
Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats |
| title_full_unstemmed |
Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats |
| title_sort |
Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats |
| dc.creator.none.fl_str_mv |
Grases Pintó, Blanca Abril Gil, Maria del Mar Rodríguez Lagunas, María José Castell, Margarida Pérez-Cano, Francisco J. Franch i Masferrer, Àngels |
| author |
Grases Pintó, Blanca |
| author_facet |
Grases Pintó, Blanca Abril Gil, Maria del Mar Rodríguez Lagunas, María José Castell, Margarida Pérez-Cano, Francisco J. Franch i Masferrer, Àngels |
| author_role |
author |
| author2 |
Abril Gil, Maria del Mar Rodríguez Lagunas, María José Castell, Margarida Pérez-Cano, Francisco J. Franch i Masferrer, Àngels |
| author2_role |
author author author author author |
| dc.subject.none.fl_str_mv |
Farmacologia Immunologia Suplements nutritius Llet materna Rates (Animals de laboratori) Pharmacology Immunology Dietary supplements Breast milk Rats as laboratory animals |
| topic |
Farmacologia Immunologia Suplements nutritius Llet materna Rates (Animals de laboratori) Pharmacology Immunology Dietary supplements Breast milk Rats as laboratory animals |
| description |
At birth, when immune responses are insufficient, there begins the development of the defence capability against pathogens. Leptin and adiponectin, adipokines that are present in breast milk, have been shown to play a role in the regulation of immune responses. We report here, for the first time, the influence of in vivo adipokine supplementation on the intestinal immune system in early life. Suckling Wistar rats were daily supplemented with leptin (0·7 μg/kg per d, n 36) or adiponectin (35 μg/kg per d, n 36) during the suckling period. The lymphocyte composition,proliferation and cytokine secretion from mesenteric lymph node lymphocytes (on days 14 and 21), as well as intestinal IgA and IgM concentration (day 21), were evaluated. At day 14, leptin supplementation significantly increased the TCRαβ+ cell proportion in mesenteric lymph nodes, in particular owing to an increase in the TCRαβ+ CD8+ cell population. Moreover, the leptin or adiponectin supplementation promoted the early development CD8+ cells, with adiponectin being the only adipokine capable of enhancing the lymphoproliferative ability at the end of the suckling period. Although leptin decreased intestinal IgA concentration, it had a trophic effect on the intestine in early life. Supplementation of both adipokines modulated the cytokine profile during (day 14) and at the end (day 21) of the suckling period. These results suggest that leptin and adiponectin during suckling play a role in the development of mucosal immunity in early life. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/166221 |
| url |
https://hdl.handle.net/2445/166221 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: https://doi.org/10.1017/S0007114517003786 British Journal of Nutrition, 2018, vol. 119, num. 5, p. 486-495 https://doi.org/10.1017/S0007114517003786 |
| dc.rights.none.fl_str_mv |
(c) Cambridge University Press, 2018 info:eu-repo/semantics/openAccess |
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(c) Cambridge University Press, 2018 |
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openAccess |
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application/pdf |
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Cambridge University Press |
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Cambridge University Press |
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Articles publicats en revistes (Bioquímica i Fisiologia) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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15,300719 |