Vector control during a pilot malaria elimination project in southern Mozambique: gaps and future opportunities

[eng] Malaria is a preventable vector-borne disease caused by Plasmodioum parasites and transmitted to humans through the bites of infected Anopheles mosquitoes. Despite the significant reductions in the burden of malaria achieved in the XXI century, progress has now stalled and 2021 saw 241 million...

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Detalhes bibliográficos
Autor: Fernandez Montoya, Lucía
Tipo de documento: tese
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/208826
Acesso em linha:https://hdl.handle.net/2445/208826
http://hdl.handle.net/10803/690340
Access Level:Acceso aberto
Palavra-chave:Malària
Moçambic
Salut pública
Salut mundial
Malaria
Mozambique
Public health
World health
id ES_2b91fe7e5515882a8a5e3d11e8cfc6db
oai_identifier_str oai:diposit.ub.edu:2445/208826
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Vector control during a pilot malaria elimination project in southern Mozambique: gaps and future opportunities
title Vector control during a pilot malaria elimination project in southern Mozambique: gaps and future opportunities
spellingShingle Vector control during a pilot malaria elimination project in southern Mozambique: gaps and future opportunities
Fernandez Montoya, Lucía
Malària
Moçambic
Salut pública
Salut mundial
Malaria
Mozambique
Public health
World health
title_short Vector control during a pilot malaria elimination project in southern Mozambique: gaps and future opportunities
title_full Vector control during a pilot malaria elimination project in southern Mozambique: gaps and future opportunities
title_fullStr Vector control during a pilot malaria elimination project in southern Mozambique: gaps and future opportunities
title_full_unstemmed Vector control during a pilot malaria elimination project in southern Mozambique: gaps and future opportunities
title_sort Vector control during a pilot malaria elimination project in southern Mozambique: gaps and future opportunities
dc.creator.none.fl_str_mv Fernandez Montoya, Lucía
author Fernandez Montoya, Lucía
author_facet Fernandez Montoya, Lucía
author_role author
dc.contributor.none.fl_str_mv Paaijmans, Krijn P.
Bassat Orellana, Quique
Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut
dc.subject.none.fl_str_mv Malària
Moçambic
Salut pública
Salut mundial
Malaria
Mozambique
Public health
World health
topic Malària
Moçambic
Salut pública
Salut mundial
Malaria
Mozambique
Public health
World health
description [eng] Malaria is a preventable vector-borne disease caused by Plasmodioum parasites and transmitted to humans through the bites of infected Anopheles mosquitoes. Despite the significant reductions in the burden of malaria achieved in the XXI century, progress has now stalled and 2021 saw 241 million clinical cases and 627 000 deaths, with most of these concentrated in sub-Saharan Africa and in children under 5 years of age. Malaria eradication was attempted in the 1950s-1980s, but although several countries eliminated malaria during that time, all attempts to eliminate malaria from sub-Saharan Africa failed, including the most comprehensive and thoroughly implemented attempt - The Garki project. The hope of malaria eradication was abandoned until 2017 when the availability of new tools, the prospective of upcoming ones and the great progress made from 2000 to 2015 raised hopes again and trigger again interested in the feasibility of eliminating malaria in Africa. In 2015, a project to evaluate the feasibility of eliminating malaria in southern Mozambique – the Magude project- was launched. It aimed to evaluate the feasibility of interrupting malaria transmission in Magude district with a comprehensive package of interventions targeting simultaneously both the parasites (through mass drug administration, diagnosis and treatment), and the vectors (through indoor residual spraying and mass distributed long-lasting insecticide nets). The project failed to interrupt local malaria transmission. This thesis identifies the vectors that managed to sustain transmission despite the interventions package, assess the gaps in vector control that hampered malaria elimination, identifies potential improvements to vector control to guide future efforts in the area and compares the Magude project with its closest relative – The Garki project – to shed light into the reasons why malaria elimination continues to be an unattainable goal in Sub-Saharan Africa.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/208826
http://hdl.handle.net/10803/690340
url https://hdl.handle.net/2445/208826
http://hdl.handle.net/10803/690340
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv cc by-nc (c) Fernandez Montoya, Lucía, 2024
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Fernandez Montoya, Lucía, 2024
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universitat de Barcelona
publisher.none.fl_str_mv Universitat de Barcelona
dc.source.none.fl_str_mv Tesis Doctorals - Facultat - Medicina i Ciències de la Salut
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Vector control during a pilot malaria elimination project in southern Mozambique: gaps and future opportunitiesFernandez Montoya, LucíaMalàriaMoçambicSalut públicaSalut mundialMalariaMozambiquePublic healthWorld health[eng] Malaria is a preventable vector-borne disease caused by Plasmodioum parasites and transmitted to humans through the bites of infected Anopheles mosquitoes. Despite the significant reductions in the burden of malaria achieved in the XXI century, progress has now stalled and 2021 saw 241 million clinical cases and 627 000 deaths, with most of these concentrated in sub-Saharan Africa and in children under 5 years of age. Malaria eradication was attempted in the 1950s-1980s, but although several countries eliminated malaria during that time, all attempts to eliminate malaria from sub-Saharan Africa failed, including the most comprehensive and thoroughly implemented attempt - The Garki project. The hope of malaria eradication was abandoned until 2017 when the availability of new tools, the prospective of upcoming ones and the great progress made from 2000 to 2015 raised hopes again and trigger again interested in the feasibility of eliminating malaria in Africa. In 2015, a project to evaluate the feasibility of eliminating malaria in southern Mozambique – the Magude project- was launched. It aimed to evaluate the feasibility of interrupting malaria transmission in Magude district with a comprehensive package of interventions targeting simultaneously both the parasites (through mass drug administration, diagnosis and treatment), and the vectors (through indoor residual spraying and mass distributed long-lasting insecticide nets). The project failed to interrupt local malaria transmission. This thesis identifies the vectors that managed to sustain transmission despite the interventions package, assess the gaps in vector control that hampered malaria elimination, identifies potential improvements to vector control to guide future efforts in the area and compares the Magude project with its closest relative – The Garki project – to shed light into the reasons why malaria elimination continues to be an unattainable goal in Sub-Saharan Africa.[spa] La malaria es una enfermedad prevenible transmitida por vectores causada por parásitos Plasmodium y transmitida a los humanos a través de la picadura de mosquitos Anopheles infectados. A pesar de las importantes reducciones en la carga de malaria logradas en el siglo XXI, el progreso se ha estancado y en 2021 se registraron 241 millones de casos clínicos y 627 000 muertes, la mayoría de las cuales se concentraron en el África subsahariana y en niños menores de 5 años. La malaria se intentó erradicar en las décadas de 1950 y 1980, y aunque varios países eliminaron la malaria durante ese tiempo, todos los intentos de eliminar la malaria del África subsahariana fracasaron, incluido el proyecto más completo de la época: el proyecto Garki. La esperanza de erradicar la malaria se abandonó hasta 2017, cuando la disponibilidad de nuevas herramientas, aquellas en desarrollo y el gran progreso logrado desde 2000 hasta 2015, despertaron nuevamente las esperanzas de eliminar la malaria y de evaluar la viabilidad de eliminación en África. En 2015, se lanzó un proyecto para evaluar la viabilidad de eliminar la malaria en el sur de Mozambique, el proyecto Magude. Su objetivo era interrumpir la transmisión de la malaria en el distrito de Magude con un paquete completo de intervenciones dirigidas simultáneamente tanto a controlar los parásitos [a través de la administración masiva de medicamentos (AMM), el diagnóstico y el tratamiento] como a controlar los vectores [a través del rociado residual intra- domiciliario (RRI) y la distribución masiva de mosquiteras tratados con insecticidas de larga duración (MTILD)]. El proyecto no logró interrumpir la transmisión local de la malaria. Esta tesis identifica los vectores que lograron mantener la transmisión a pesar del paquete de intervenciones, evalúa las brechas en el control de vectores que dificultaron la eliminación de la malaria, identifica posibles mejoras en el control de vectores para guiar los esfuerzos futuros en el área y compara el proyecto Magude con su pariente más cercano, el proyecto Garki, para arrojar luz sobre las razones por las que la eliminación de la malaria sigue siendo un objetivo inalcanzable en el África subsahariana.Universitat de BarcelonaPaaijmans, Krijn P.Bassat Orellana, QuiqueUniversitat de Barcelona. Facultat de Medicina i Ciències de la Salut2022info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/208826http://hdl.handle.net/10803/690340Tesis Doctorals - Facultat - Medicina i Ciències de la Salutreponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaIngléscc by-nc (c) Fernandez Montoya, Lucía, 2024http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2088262026-05-27T06:46:51Z
score 15,301629

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