Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study

Introduction Migraine is a primary headache showing a multifactorial component that includes altered pain processing, psychological/emotional problems, neurocognitive and executive function deficits, all with a possible genetic association. The aim of the current study will be to evaluate the associ...

Descripción completa

Detalles Bibliográficos
Autores: Fernández de las Peñas, Cesar, Cigarán Méndez, Margarita, Ambite Quesada, Silvia, Gómez Calero, Cristina, Fernández Palacios, Francisco Ginés, Pacho Hernández, Juan C, Tejera Alonso, Angela, Plaza Manzano, Gustavo, Valera Calero, Juan Antonio, Alvarez Mariño, Beatriz, Ordás Bandera, Carlos, Arendt Nielsen, Lars, de la Llave Rincón, Ana I
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/131842
Acceso en línea:https://hdl.handle.net/20.500.14352/131842
Access Level:acceso abierto
Palabra clave:61
Ciencias Biomédicas
3299 Otras Especialidades Médicas
id ES_2b8307cd4168f7020b54c19a82c089cd
oai_identifier_str oai:docta.ucm.es:20.500.14352/131842
network_acronym_str ES
network_name_str España
repository_id_str
spelling Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control studyFernández de las Peñas, CesarCigarán Méndez, MargaritaAmbite Quesada, SilviaGómez Calero, CristinaFernández Palacios, Francisco GinésPacho Hernández, Juan CTejera Alonso, AngelaPlaza Manzano, GustavoValera Calero, Juan AntonioAlvarez Mariño, BeatrizOrdás Bandera, CarlosArendt Nielsen, Larsde la Llave Rincón, Ana I61Ciencias Biomédicas3299 Otras Especialidades MédicasIntroduction Migraine is a primary headache showing a multifactorial component that includes altered pain processing, psychological/emotional problems, neurocognitive and executive function deficits, all with a possible genetic association. The aim of the current study will be to evaluate the association between sensitisation, psychological/emotional, neurocognitive and genetic profile on conditioned pain modulation (CPM) in women with migraine from a multidisciplinary perspective. Methods and analysis A cross-sectional observational case-control study including 90 women with chronic migraine, 90 women with episodic migraine and 90 women without migraine (as controls) will be conducted. Clinical variables (disability, pain), processing (sensitisation-associated, neuropathic-like symptoms), psychological/emotional (anxiety, depression, sleep quality, catastrophising), neurocognitive (attention), executive functions (memory, mental inhibition, speed processing) and genetics (Val158Met polymorphism rs4680 gene) will be assessed in all subjects by healthcare professionals. Subsequently, CPM will be evaluated with the cold-pressor test paradigm by assessing changes obtained in mechanical and thermal stimuli. The association of each group of variables on CPM will be analysed with multivariate analyses (OMNIBUS analysis of variance). A network model will also be created to identify those variables showing the greatest key measure of centrality with the rest of the severity indicators (strength, intermediation and closeness) to establish the potentially therapeutic targets in patients with migraine from a multidisciplinary point of view. Ethics and dissemination The protocol of the current study has been approved by the Ethics Committee of all involved institutions (Hospital Universitario Fundación Alcorcón 24-117, Universidad Rey Juan Carlos 010220240912024). All procedures will be conducted following the Declaration of Helsinki. Participants will be informed of the aims and procedures of the study and will receive the informed written consent which should be signed before their inclusion. Study results will be disseminated through peer-reviewed publications and presentations at scientific meetings.BMJ Publishing GroupUniversidad Complutense de Madrid20252025-07-2820252025-07-28journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/131842reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1318422026-06-02T12:44:21Z
dc.title.none.fl_str_mv Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study
title Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study
spellingShingle Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study
Fernández de las Peñas, Cesar
61
Ciencias Biomédicas
3299 Otras Especialidades Médicas
title_short Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study
title_full Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study
title_fullStr Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study
title_full_unstemmed Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study
title_sort Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study
dc.creator.none.fl_str_mv Fernández de las Peñas, Cesar
Cigarán Méndez, Margarita
Ambite Quesada, Silvia
Gómez Calero, Cristina
Fernández Palacios, Francisco Ginés
Pacho Hernández, Juan C
Tejera Alonso, Angela
Plaza Manzano, Gustavo
Valera Calero, Juan Antonio
Alvarez Mariño, Beatriz
Ordás Bandera, Carlos
Arendt Nielsen, Lars
de la Llave Rincón, Ana I
author Fernández de las Peñas, Cesar
author_facet Fernández de las Peñas, Cesar
Cigarán Méndez, Margarita
Ambite Quesada, Silvia
Gómez Calero, Cristina
Fernández Palacios, Francisco Ginés
Pacho Hernández, Juan C
Tejera Alonso, Angela
Plaza Manzano, Gustavo
Valera Calero, Juan Antonio
Alvarez Mariño, Beatriz
Ordás Bandera, Carlos
Arendt Nielsen, Lars
de la Llave Rincón, Ana I
author_role author
author2 Cigarán Méndez, Margarita
Ambite Quesada, Silvia
Gómez Calero, Cristina
Fernández Palacios, Francisco Ginés
Pacho Hernández, Juan C
Tejera Alonso, Angela
Plaza Manzano, Gustavo
Valera Calero, Juan Antonio
Alvarez Mariño, Beatriz
Ordás Bandera, Carlos
Arendt Nielsen, Lars
de la Llave Rincón, Ana I
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 61
Ciencias Biomédicas
3299 Otras Especialidades Médicas
topic 61
Ciencias Biomédicas
3299 Otras Especialidades Médicas
description Introduction Migraine is a primary headache showing a multifactorial component that includes altered pain processing, psychological/emotional problems, neurocognitive and executive function deficits, all with a possible genetic association. The aim of the current study will be to evaluate the association between sensitisation, psychological/emotional, neurocognitive and genetic profile on conditioned pain modulation (CPM) in women with migraine from a multidisciplinary perspective. Methods and analysis A cross-sectional observational case-control study including 90 women with chronic migraine, 90 women with episodic migraine and 90 women without migraine (as controls) will be conducted. Clinical variables (disability, pain), processing (sensitisation-associated, neuropathic-like symptoms), psychological/emotional (anxiety, depression, sleep quality, catastrophising), neurocognitive (attention), executive functions (memory, mental inhibition, speed processing) and genetics (Val158Met polymorphism rs4680 gene) will be assessed in all subjects by healthcare professionals. Subsequently, CPM will be evaluated with the cold-pressor test paradigm by assessing changes obtained in mechanical and thermal stimuli. The association of each group of variables on CPM will be analysed with multivariate analyses (OMNIBUS analysis of variance). A network model will also be created to identify those variables showing the greatest key measure of centrality with the rest of the severity indicators (strength, intermediation and closeness) to establish the potentially therapeutic targets in patients with migraine from a multidisciplinary point of view. Ethics and dissemination The protocol of the current study has been approved by the Ethics Committee of all involved institutions (Hospital Universitario Fundación Alcorcón 24-117, Universidad Rey Juan Carlos 010220240912024). All procedures will be conducted following the Declaration of Helsinki. Participants will be informed of the aims and procedures of the study and will receive the informed written consent which should be signed before their inclusion. Study results will be disseminated through peer-reviewed publications and presentations at scientific meetings.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-07-28
2025
2025-07-28
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/131842
url https://hdl.handle.net/20.500.14352/131842
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869405149025271808
score 15,811543

Similares en LA Referencia